On the cover
Le Dréau et al. report that the activity levels of the canonical BMP effectors SMAD1 and SMAD5 dictate the mode of stem cell division—self-expanding, self-renewing, or self-consuming—during spinal cord formation. A mirror-reconstruction image of a transverse section through the developing spinal cord of a chick embryo shows the expression patterns of the reporters pSox2:eGFP (green) and pTis21:RFP (red), which are active during progenitor-generating and neuron-generating divisions, respectively. The apical and basal membranes of the neural tube are labeled white.
Image © 2014 Le Dréau et al.
See page 591.
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Structure–function analyses driven by a crystal structure of the cytosolic domain of the Drp1 receptor MiD51 reveals a nucleotidyltransferase fold and nucleotide binding activity that is independent of its Drp1 binding activity.
During epithelial cell polarization, aPKC phosphorylates Yurt to prevent its premature apical localization, while at the same time Yurt binds to and restrains aPKC function.
In growing Dictyostelium discoideum, PIP3 is unnecessary for migration toward folate and actively inhibits chemotaxis and pseudopod formation by promoting macropinocytosis.
CDK phosphorylation of SLD-2 is required for replication initiation and germline development in C. elegans
Timely phosphorylation of SLD-2 by CDK is essential for proper replication initiation and cell proliferation in the germline of C. elegans.
Ndc1–Mps3 interaction is important for controlling the distribution of Ndc1 between the nuclear pore complex and spindle pole body to ensure proper nuclear envelope insertion of both complexes.
The acyl-CoA–binding protein Atg37 is a new component of the pexophagic receptor protein complex that regulates the recruitment of Atg11 by Atg30 in the peroxisomal membrane during pexophagy
An aggregation state–dependent mechanism for segregation of plasma membrane protein complexes confers specific functional roles to the M1 and M23 isoforms of the water channel AQP4.
Rho GTPase signaling establishes a planar polarized actomyosin network within which the actin-binding protein Shroom enhances myosin activity locally to generate robust mechanical forces during axis elongation.
The strength of SMAD1/5 activity determines the mode of stem cell division in the developing spinal cord
The activity level of the BMP effectors SMAD1/5 dictates whether stem cell divisions are self-expanding, self-renewing, or self-consuming during spinal interneuron generation.
Activation of the TAK1 kinase drives RIPK3-dependent necrosis and inhibits apoptosis downstream of TNF-α stimulation.