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Cover Image
Cover Image
On the cover
The kinesin motor protein KIF13B (green) localizes beneath the sinusoidal plasma membrane of mouse liver hepatocytes, where low-density lipoprotein and other proteins are taken up from neighboring blood vessels. Actin is labeled red. Kanai et al. reveal that KIF13B lowers blood cholesterol levels by promoting the caveolin-dependent endocytosis of the LDL receptor LRP1.
Image © 2014 Kanai et al.
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In This Issue
In Focus
KIF13B erects an endocytic scaffold
A kinesin motor promotes the endocytosis of the membrane receptor LRP1 by recruiting it to caveolae.
People & Ideas
Ottoline Leyser: The beauty of plant genetics
Leyser studies how plant hormones shape body plan in Arabidopsis.
Review
Report
Reduction of endoplasmic reticulum stress attenuates the defects caused by Drosophila mitofusin depletion
The developmental and motor defects evident in flies depleted of the mitofusin Marf can be ameliorated by treatments that reduce ER stress, confirming an active role for ER stress in the observed phenotypes.
Article
CAL1 is the Drosophila CENP-A assembly factor
Representing a unique family of histone assembly factors, CAL1 assembles the histone H3 variant CENP-A on centromeric DNA in Drosophila.
Neuronal cell type–specific alternative splicing is regulated by the KH domain protein SLM1
Cell type–specific expression of the splicing regulator SLM1 provides a mechanism for shaping the molecular repertoires of synaptic adhesion molecules in neuronal populations in vivo.
Early endosome motility spatially organizes polysome distribution
To distribute the protein translation machinery throughout the cytoplasm, polysomes in the fungus Ustilago maydis associate with mobile early endosomes, resulting in long-range motility along microtubules.
PP2ARts1 is a master regulator of pathways that control cell size
PP2ARts1 controls diverse pathways that influence cell size and may link cell cycle entry to cell growth via the transcription factor Ace2.
A G protein–coupled receptor and the intracellular synthase of its agonist functionally cooperate
The GPCR DP1 promotes the activity of L-PGDS, the enzyme that produces the DP1 agonist PGD2, while at the same time L-PGDS promotes the export and activity of DP1 in response to PGD2.
KIF13B enhances the endocytosis of LRP1 by recruiting LRP1 to caveolae
The motor protein KIF13B has an unconventional role as a scaffold that recruits lipoprotein receptor–related protein 1 to caveolae, thereby enhancing its endocytosis.
The composition of EphB2 clusters determines the strength in the cellular repulsion response
Graded responses to cell–cell repulsion signals mediated by Ephrin–Eph receptor interactions are specified by EphB2 cluster composition, such that the relative abundance of inactive dimers and active higher-order clusters determines the strength of the repulsive response.
Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs
PrPSc forms micrometer long amyloidic strings that can congregate in clusters and webs at the surface of living cells.
Tools
CellGeo: A computational platform for the analysis of shape changes in cells with complex geometries
The open source MATLAB application CellGeo is a user-friendly computational platform that allows simultaneous, automated tracking and analysis of dynamic changes in cell shape, including protrusions ranging from filopodia to lamellipodia to growth cones.
