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Tumor suppressor could stop cancer through its effect on actin cytoskeleton.

People & Ideas

Morrison compares different stem cells to understand the mechanisms that regulate regeneration, cancer, and aging.



3D reconstruction by cryo-EM provides the first structural description of a ribosomal biogenesis factor (Nmd3) in complex with the 60S ribosomal subunit.

The microtubule regulator APC is now shown to also regulate actin filament dynamics through its C-terminal “Basic” domain.

CHC binds specifically to aurora A–phosphorylated TACC3, recruiting it to the spindle during mitosis.

Vinculin localizes to tension-bearing cell–cell junctions to help transmit signals from E-cadherin to the actin cytoskeleton in response to mechanical stress.


Polν and Polθ have specialized functions in immunoglobulin gene rearrangements and only contribute to DNA repair when other homologous recombination–related DNA polymerases are absent.

Depletion of the Nup188–Nup93 nuclear pore complex results in enlarged nuclei due to unrestricted protein import.

CENP-C and CENP-N recognize distinct structural elements of CENP-A nucleosomes, providing a foundation for the assembly of other centromere and kinetochore components.

mTOR induces MyoD-dependent miR-1 expression, leading to follistatin-mediated myocyte fusion.

Lysosomes lose cations to balance the influx of protons as the organelle acidifies.


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