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Cover Image
Cover Image
On the cover
In the Drosophila visual system, photoreceptor neurons (green) project toward the optic lobe and form synaptic connections in the neuropil (red). Nuclei are labeled blue. Williamson et al. show that the neuron-specific v-ATPase subunit v100 has a dual function in sorting and degrading proteins through the endolysosomal pathway, protecting the photoreceptors from neurodegeneration.
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In This Issue
In Focus
The acid test of v-ATPase function
The vesicular protein complex has a dual role in sorting and degrading neuronal proteins.
People & Ideas
Inke Näthke: The ABCs of APC
Näthke investigates the many functions of adenomatous polyposis coli protein and its contribution to human disease.
Review
Article
Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution
A previously unrecognized pore membrane protein, Pom33, stabilizes the interface between the nuclear envelope and the NPC to facilitate NPC biogenesis and spatial organization.
Dcp2 phosphorylation by Ste20 modulates stress granule assembly and mRNA decay in Saccharomyces cerevisiae
The Ste20 kinase targets the decapping enzyme Dcp2 during stress responses, allowing accumulation of Dcp2 in P-bodies and the formation of stress granules.
The role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an obligate substrate prosaposin
A natural substrate for UGT1 is confirmed, revealing how the enzyme functions in the calnexin chaperone system as a quality control step in protein folding.
Regulation of O-glycosylation through Golgi-to-ER relocation of initiation enzymes
Growth factor stimulation moves O-glycosylation initiation enzymes (GalNac-Ts) from the Golgi to the ER in a Src-dependent fashion, increasing protein O-glycosylation.
Nebulin regulates actin filament lengths by a stabilization mechanism
The nebulin molecular ruler hypothesis is challenged as a truncated form of nebulin can stabilize actin filaments that are longer than the mini-nebulin itself.
Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor
Four independent mechanisms for uptake of activated EGFR are identified by a combination of receptor mutagenesis and RNA interference approaches.
A dual function of V0-ATPase a1 provides an endolysosomal degradation mechanism in Drosophila melanogaster photoreceptors
A vesicular ATPase regulates both vesicle fusion and subsequent acidification of a subset of neuronal lysosomes and autophagosomes.
Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5α/β
A newly discovered interaction between LL5s, laminins, and integrins reveals how the extracellular matrix directs microtubule polarity in epithelial tissues.
