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In Focus

The vesicular protein complex has a dual role in sorting and degrading neuronal proteins.

People & Ideas

Näthke investigates the many functions of adenomatous polyposis coli protein and its contribution to human disease.



A previously unrecognized pore membrane protein, Pom33, stabilizes the interface between the nuclear envelope and the NPC to facilitate NPC biogenesis and spatial organization.

The Ste20 kinase targets the decapping enzyme Dcp2 during stress responses, allowing accumulation of Dcp2 in P-bodies and the formation of stress granules.

A natural substrate for UGT1 is confirmed, revealing how the enzyme functions in the calnexin chaperone system as a quality control step in protein folding.

Growth factor stimulation moves O-glycosylation initiation enzymes (GalNac-Ts) from the Golgi to the ER in a Src-dependent fashion, increasing protein O-glycosylation.

The nebulin molecular ruler hypothesis is challenged as a truncated form of nebulin can stabilize actin filaments that are longer than the mini-nebulin itself.

Four independent mechanisms for uptake of activated EGFR are identified by a combination of receptor mutagenesis and RNA interference approaches.

A vesicular ATPase regulates both vesicle fusion and subsequent acidification of a subset of neuronal lysosomes and autophagosomes.

A newly discovered interaction between LL5s, laminins, and integrins reveals how the extracellular matrix directs microtubule polarity in epithelial tissues.

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