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ISSN 0021-9525
EISSN 1540-8140
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Two studies reveal how kinetochores stay attached to dynamic microtubules.

People & Ideas

Dillin uses genetics to probe the pathways that control cellular and organismal longevity.

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Cdc14A and Cdc14B knockout cells with double-strand breaks still arrest in G2, but they fail to repair the damage.

The Ndc80 complex of kinetochores doesn't recognize microtubule tips by itself but relies on the Dam1 complex to track microtubule plus ends (see also related paper by Tien et al. in this issue).

Phosphorylation of a dynactin subunit is important for its release from mitotic spindles.

An RNAi screen picks Tuba out of the GTPase exchange factor (GEF) orchestra as a regulator of cell polarity in epithelial morphogenesis. (See also a companion paper from Rodriguez-Fraticelli et al., in this issue.)

Parkin catalyzes mitochondrial ubiquitination, recruiting autophagic components that clear damaged mitochondria. Defects in this pathway are implicated in Parkinson's disease.

A microtubule arm regulates cell–cell repulsion, pointing hemocytes in opposite directions when they contact each other in Drosophila embryos.

Botulinum neurotoxin's nontoxic HA protein binds E-cadherin to disrupt cell–cell adhesion in a species-specific manner.

Article

The Sox10 transcription factor is required to maintain as well as specify glial identity, adding new causes for the neuropathies associated with SOX10 mutations.

The Dam1 complex, regulated by aurora B phosphorylation, confers a more stable microtubule association for the Ndc80 complex at kinetochores (see also related paper by Lampert et al. in this issue).

Intersectin 2 localizes to centrosomes, where it regulates Cdc42 and helps to orient the apical surface correctly during cyst formation. (See also companion paper from Qin et al., in this issue.)

QUBIC, a specific and highly sensitive method for detection of protein–protein interactions, is used to identify new partners for the mitotic spindle components pericentrin and TACC3.

The myosin Myo4 is nonprocessive by itself, but when several motor subunits team up with She2 and She3, it forms an active RNP transport unit that moves ASH1 mRNA to the bud tip in dividing yeast.

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