Journal of Experimental Medicine (JEM) | Rockefeller University Press

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Innate Immune Signaling in Infection and Disease

A special collection of recent articles in JEM.
Updates on The Immune Responses in Tuberculosis

A special collection of recent articles in JEM.

Newest Articles

Article

| April 06 2026

Nasal tissue CD4 TRM protect against influenza

Nimitha R. Mathew et al.

Mathew et al. demonstrate that CD4 TRM form in the nasal tissue during influenza A virus infection. Influenza-specific CD4 TRM are predominantly Th17, depend on local antigen and CXCR6–CXCL16 axis for formation and maintenance, and are protective upon reinfection.

Article

| April 02 2026

Dual HIF-1/2 inhibitors for cancer therapy

Shaima Salman et al.

Hypoxia-inducible factors 1 and 2 (HIF-1/2) play critical roles in cancer progression. We have developed the first dual HIF-1/2 inhibitors that bind to the most highly conserved domains of both proteins, show activity against a wide range of cancers, are orally bioavailable, and markedly improve responses to immune checkpoint blockade in mouse tumor models.

Article

| March 31 2026

Proinflammatory functions of Blimp-1 in ILC2s

Patrycja M. Forster et al.

Forster et al. identify the transcriptional network controlling effector functions of ILC2s downstream of the IL-33 receptor. They found that the Blimp-1–IRF4 axis regulates IL-5 and IL-13 production in ILC2s, driving either worm expulsion or eosinophilia during allergic lung inflammation.

Article

| March 27 2026

MEKK3–KLF2/4 signaling activates TIE2 in CCM

Lun Li et al.

Endothelial cell gain of MEKK3–KLF2/4 signaling confers CCM by increasing PI3K signaling. We show that the TIE2 receptor links MEKK3–KLF2/4 and PI3K signaling during CCM formation, identifying TIE2 inhibition as a potential treatment strategy for CCM disease.

Article

| March 27 2026

Targeting Mettl8–Tcf1 to reprogram T_PEX

Jiaxi Song et al.

The study reveals that Mettl8 maintains stem-like T_PEX cells by stabilizing Tcf1 via m³C modification and facilitating chromatin looping at the Tox locus. Its deletion or inhibition drives T_PEX differentiation into effective Int-T_EX cells, restraining tumor growth and synergizing with anti–PD-1 therapy, thus presenting a promising immunotherapeutic target.

Article

| March 26 2026

Basophils drive wounds resolution

Julie Bex et al.

The resolution of inflammation is essential for homeostasis and becomes defective with age. Here, Bex et al. show that basophils infiltrate wounds to promote the resolution and healing in both adult and aged mice.

Technical Advances and Resources

| March 25 2026

In vivo gene editing of fibroblasts

Nicholas F. Kuhn et al.

CAFs are prominent members of the TME. Kuhn et al. demonstrate how local gene editing of CAFs alters their cell state and, subsequently, the cellular TME. This approach demonstrates a method to investigate intercellular circuits using targeted genetic perturbations in CAFs.

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Current Issue

Volume 223,

Issue 4,

6 April 2026

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Reviews & Opinions

Review | Cancer Focus

| March 31 2026

Inhibitory receptor agonists

Kieran R. Adam et al.

In this review, Adam et al. highlights the challenges and novel approaches to developing agonistic IR-targeted therapies to treat autoimmunity and inflammatory disorders.

Insights

| March 25 2026

The endothelium is a checkpoint for energy storage

M. Luisa Iruela-Arispe

Wetternwald and colleagues show that endothelial cells actively regulate energy storage in white adipose tissue through MYCT1–IFITM2/3-dependent control of endolysosomal trafficking and mTORC1 signaling. By limiting their own nutrient consumption, endothelial cells influence systemic energy partitioning, redefining the vasculature as a metabolic gatekeeper rather than a passive conduit.

Review | Genes and Immunity Focus

| March 23 2026

Monoallelic expression—determinant of penetrance

Dusan Bogunovic

Humans are disomic, with paired maternal and paternal autosomes presumed equally expressed. Autosomal random monoallelic expression challenges this paradigm and may underlie incomplete penetrance in diverse genetic diseases while allowing for personal evolution within the inherited genetic constraints.

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Special Collections

The Year in Experimental Medicine

Our annual series highlighting articles that were of greatest interest to our readers in 2025.

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How to comply with NIH and HHMI publication policies.

Discover how JEM’s collaborative model puts your science first.

A special collection of recent articles in JEM.

A special collection of recent articles in JEM.

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