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Follow the “DOTs”: Vδ1⁺ γδ T cells as effectors of cancer immunotherapy

Bruno Silva-Santos, Sofia Mensurado, Rafael Blanco-Domínguez, Adrian C. Hayday

J Exp Med (2026) 223 (3): e20252289.

https://doi.org/10.1084/jem.20252289

Published: 11 February 2026

View article titled, Follow the “DOTs”: Vδ1+ γδ T cells as effectors of cancer immunotherapy

Journal Articles

Nasal germinal centers and IgA class-switch recombination depend on CCR6 and B cell receptor affinity

Jingjing Liu, Liat Stoler-Barak, Ziv Shulman

J Exp Med (2026) 223 (4): e20251901.

https://doi.org/10.1084/jem.20251901

Published: 10 February 2026

View article titled, Nasal germinal centers and IgA class-switch recombination depend on CCR6 and B cell receptor affinity

Journal Articles

Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity

Benjamin N. Ostendorf, Jonathan G. Goldstein, Shuang Liu, Foster C. Gonsalves, Jana Bilanovic, Mathias Yuan, Ji-Young Kim, Christopher Rouya, Masoud Tavazoie, Sohail F. Tavazoie

J Exp Med (2026) 223 (4): e20252290.

https://doi.org/10.1084/jem.20252290

Published: 10 February 2026

View article titled, Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity

Includes: Supplementary data

Journal Articles

Zbtb32 promotes CD8⁺ T cell differentiation and function in cancer

Birui Pan, Qinli Sun, Ruifeng Li, Juan Feng, Jing Hao, Bowen Xie, Xiaohong Zhao, Zixuan Zhao, Peng Wei, Qiuyan Lan, Shiyuan Xie, Tian Xie, Yongzhen Chen, Kun Wei, Xuan Zhong, Hai Qi, Ling Ni, Chen Dong

J Exp Med (2026) 223 (4): e20250005.

https://doi.org/10.1084/jem.20250005

Published: 06 February 2026

View article titled, Zbtb32 promotes CD8+ T cell differentiation and function in cancer

Includes: Supplementary data

Journal Articles

Correction: Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function

Shih-Ying Wu, Fei Xing, Sambad Sharma, Kerui Wu, Abhishek Tyagi, Yin Liu, Dan Zhao, Ravindra Pramod Deshpande, Yusuke Shiozawa, Tamjeed Ahmed, Wei Zhang, Michael Chan, Jimmy Ruiz, Thomas W. Lycan, Andrew Dothard, Kounosuke Watabe

J Exp Med (2026) 223 (3): e2019113101262026c.

https://doi.org/10.1084/jem.2019113101262026c

Published: 05 February 2026

View article titled, Correction: Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function

Journal Articles

Epigenetic and metabolic reprogramming support plasma cell differentiation in germinal centers

Yuliang Wang, Xinyi Yang, Mengting Lou, Tiantian Chen, Wen Li, Cuifang Yang, Le Zhang, Zhenming Cai, Yuren Fan, Sulan Zhai, Shengze Zhang, Yunli Wang, Xiaoming Wang, Jingjing Chen

J Exp Med (2026) 223 (3): e20250569.

https://doi.org/10.1084/jem.20250569

Published: 28 January 2026

View article titled, Epigenetic and metabolic reprogramming support plasma cell differentiation in germinal centers

Journal Articles

In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation

Lesly Calderón, Markus Schäfer, Marina Rončević, René Rauschmeier, Markus Jaritz, Tanja A. Schwickert, Qiong Sun, Andrea Pauli, Johannes Zuber, Meinrad Busslinger

J Exp Med (2026) 223 (3): e20250594.

https://doi.org/10.1084/jem.20250594

Published: 28 January 2026

View article titled, In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation

Includes: Supplementary data

Journal Articles

DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells

J Exp Med (2026) 223 (3): e20241707.

https://doi.org/10.1084/jem.20241707

Published: 28 January 2026

View article titled, DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells

Includes: Supplementary data

Journal Articles

MHC one–two punch knocks out cancer

Amir Ghorbani, Jonathan W. Yewdell

J Exp Med (2026) 223 (2): e20252203.

https://doi.org/10.1084/jem.20252203

Published: 20 January 2026

View article titled, MHC one–two punch knocks out cancer

Journal Articles

Correction: Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology

J Exp Med (2026) 223 (3): e2025106701072026c.

https://doi.org/10.1084/jem.2025106701072026c

Published: 14 January 2026

View article titled, Correction: Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology

Journal Articles

Correction: Dominant negative ADA2 mutations cause ADA2 deficiency in heterozygous carriers

Marjon Wouters, Lisa Ehlers, Wout Van Eynde, Meltem Ece Kars, Selket Delafontaine, Verena Kienapfel, Mariia Dzhus, Rik Schrijvers, Petra De Haes, Sofie Struyf, Giorgia Bucciol, Yuval Itan, Alexandre Bolze, Arnout Voet, Anneleen Hombrouck, Leen Moens, Benson Ogunjimi, Isabelle Meyts

J Exp Med (2026) 223 (2): e2025049912162025c.

https://doi.org/10.1084/jem.2025049912162025c

Published: 09 January 2026

View article titled, Correction: Dominant negative ADA2 mutations cause ADA2 deficiency in heterozygous carriers

Journal Articles

Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology

J Exp Med (2026) 223 (3): e20251067.

https://doi.org/10.1084/jem.20251067

Published: 05 January 2026

View article titled, Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology

Includes: Supplementary data

Journal Articles

Claudin 1–mediated positioning of DC1 to mTECs is essential for maintenance of central tolerance

In Special Collection:

Immunology Update Winter 2026

J Exp Med (2026) 223 (3): e20250970.

https://doi.org/10.1084/jem.20250970

Published: 02 January 2026

View article titled, Claudin 1–mediated positioning of DC1 to mTECs is essential for maintenance of central tolerance

Includes: Supplementary data

Journal Articles

Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging

J Exp Med (2025) 223 (2): e20251805.

https://doi.org/10.1084/jem.20251805

Published: 30 December 2025

View article titled, Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging

Includes: Supplementary data

Journal Articles

The cribriform plate: A dynamic central nervous system–immune hub

In Special Collection:

Immunology Update Winter 2026

Collin J. Laaker, Sophia M. Vrba, Jenna M. Port, Martin Hsu, Cameron M. Baenen, Melinda Herbath, Thanthrige Thiunuwan Priyathilaka, Matyas Sandor, Zsuzsanna Fabry

J Exp Med (2025) 223 (2): e20251871.

https://doi.org/10.1084/jem.20251871

Published: 30 December 2025

View article titled, The cribriform plate: A dynamic central nervous system–immune hub

Journal Articles

Transcription of HIV-1 is heterogenous among authentic latent CD4⁺ T cell clones

Cintia Bittar, Ana Rafaela Teixeira, Thiago Y. Oliveira, Gabriela S. Silva Santos, Klara Lenart, Marcilio Jorge Fumagalli, Georg H.J. Weymar, Anna Kaczynska, Noemi L. Linden, Isabella A.T.M. Ferreira, Marina Caskey, R. Brad Jones, Mila Jankovic, Michel C. Nussenzweig

J Exp Med (2025) 223 (3): e20251584.

https://doi.org/10.1084/jem.20251584

Published: 26 December 2025

View article titled, Transcription of HIV-1 is heterogenous among authentic latent CD4+ T cell clones

Includes: Supplementary data

Journal Articles

FOXO1 re-expression with a dual-recombinase allele rescues class switching in germinal center B cells

Carlota Farré Díaz, Eleni Kabrani, Wiebke Winkler, Eric Blanc, Brigitte Wollert-Wulf, Claudia Salomon, F. Thomas Wunderlich, Dieter Beule, Martin Janz, Klaus Rajewsky

J Exp Med (2025) 223 (3): e20241136.

https://doi.org/10.1084/jem.20241136

Published: 26 December 2025

View article titled, FOXO1 re-expression with a dual-recombinase allele rescues class switching in germinal center B cells

Includes: Supplementary data

Journal Articles

Tet2 deficiency–induced expansion of monocyte-derived macrophages promotes liver fibrosis

Jiuxing Feng, Baitong Wu, Yu Li, Pengli Sun, Qian Liu, Qianxue Xiao, Jia-Bin Cai, Yimin Zheng, Haonan Chen, Yichi Xu, Yixin Liu, Guo-Ming Shi, Li Tan, Yujiang Geno Shi

J Exp Med (2025) 223 (2): e20251114.

https://doi.org/10.1084/jem.20251114

Published: 26 December 2025

View article titled, Tet2 deficiency–induced expansion of monocyte-derived macrophages promotes liver fibrosis

Includes: Supplementary data

Journal Articles

ERAdP facilitates biogenesis of dense core vesicles in Paneth cells to enhance intestinal defense

In Special Collection:

Immunology Update Winter 2026

Cunzhen Li, Zhen Xiong, Deyuan Kong, Yuwei Xu, Runyuan Wu, Peikang Zhang, Ziqi Xiao, Hui Guo, Ying Du, JinSong Li, Yun Chen, Qiang Zhan, Zusen Fan

J Exp Med (2025) 223 (2): e20251051.

https://doi.org/10.1084/jem.20251051

Published: 26 December 2025

View article titled, ERAdP facilitates biogenesis of dense core vesicles in Paneth cells to enhance intestinal defense

Includes: Supplementary data

Journal Articles

T cell engagers emerge as a compelling therapeutic modality

In Special Collection:

Immunology Update Winter 2026

P.A. Baeuerle, K. Sauer, R. Grieshaber-Bouyer, J.S. Michaelson

J Exp Med (2025) 223 (2): e20251652.

https://doi.org/10.1084/jem.20251652

Published: 26 December 2025

View article titled, T cell engagers emerge as a compelling therapeutic modality

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Follow the “DOTs”: Vδ1⁺ γδ T cells as effectors of cancer immunotherapy

Nasal germinal centers and IgA class-switch recombination depend on CCR6 and B cell receptor affinity

Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity

Zbtb32 promotes CD8⁺ T cell differentiation and function in cancer

Correction: Nicotine promotes brain metastasis by polarizing microglia and suppressing innate immune function

Epigenetic and metabolic reprogramming support plasma cell differentiation in germinal centers

In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation

DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells

MHC one–two punch knocks out cancer

Correction: Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology

Correction: Dominant negative ADA2 mutations cause ADA2 deficiency in heterozygous carriers

Single-cell and spatial profiling highlights TB-induced myofibroblasts as drivers of lung pathology

Claudin 1–mediated positioning of DC1 to mTECs is essential for maintenance of central tolerance

Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging

The cribriform plate: A dynamic central nervous system–immune hub

Transcription of HIV-1 is heterogenous among authentic latent CD4⁺ T cell clones

FOXO1 re-expression with a dual-recombinase allele rescues class switching in germinal center B cells

Tet2 deficiency–induced expansion of monocyte-derived macrophages promotes liver fibrosis

ERAdP facilitates biogenesis of dense core vesicles in Paneth cells to enhance intestinal defense

T cell engagers emerge as a compelling therapeutic modality

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