Differences in the release site location influence mGluR6 activity. (A) Illustrations of rods 1–4 with their postsynaptic cells. BPs 1 and 2 are shown in magenta (BP1) and red (BP2), respectively. Ribbons are shown in transparent blue. Rod membranes have been removed for easier visualization. Visible release sites are indicated by arrows. The release site corresponding to the magenta trace in BP1 of rod 1 (B) is shown with a magenta arrow. (B) Plot of the time course of mGluR6 activated by release at six sites, three on each face of the ribbon. Responses of the two RBPs beneath each rod terminal (BP1 and BP2) are plotted separately. Insets beneath Rod 2 show the effect on mGluR6 activity of increasing the ECV of the synaptic cleft from 0.11 to 0.3. All graphs are the mean ± SD of 25 simulations.
Figure 8.

Differences in the release site location influence mGluR6 activity. (A) Illustrations of rods 1–4 with their postsynaptic cells. BPs 1 and 2 are shown in magenta (BP1) and red (BP2), respectively. Ribbons are shown in transparent blue. Rod membranes have been removed for easier visualization. Visible release sites are indicated by arrows. The release site corresponding to the magenta trace in BP1 of rod 1 (B) is shown with a magenta arrow. (B) Plot of the time course of mGluR6 activated by release at six sites, three on each face of the ribbon. Responses of the two RBPs beneath each rod terminal (BP1 and BP2) are plotted separately. Insets beneath Rod 2 show the effect on mGluR6 activity of increasing the ECV of the synaptic cleft from 0.11 to 0.3. All graphs are the mean ± SD of 25 simulations.

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