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Journal Articles

Mathematical modeling of intracellular osmolarity and cell volume stabilization: The Donnan effect and ion transport

Zahra Aminzare, Alan R. Kay

J Gen Physiol (2024) 156 (8): e202413554.

https://doi.org/10.1085/jgp.202413554

Published: 12 July 2024

View article titled, Mathematical modeling of intracellular osmolarity and cell volume stabilization: The Donnan effect and ion transport

Journal Articles

Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue

Eduardo Ríos, Montserrat Samsó, Lourdes C. Figueroa, Carlo Manno, Eshwar R. Tammineni, Lucas Rios Giordano, Sheila Riazi

J Gen Physiol (2024) 156 (9): e202413595.

https://doi.org/10.1085/jgp.202413595

Published: 09 July 2024

View article titled, Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue

Includes: Supplementary data

Journal Articles

Fusion pore flux controls the rise-times of quantal synaptic responses

In Special Collection:

Molecular Insights into Membrane Protein Function

Meyer B. Jackson, Chung-Wei Chiang, Jinbo Cheng

J Gen Physiol (2024) 156 (8): e202313484.

https://doi.org/10.1085/jgp.202313484

Published: 11 June 2024

View article titled, Fusion pore flux controls the rise-times of quantal synaptic responses

Journal Articles

Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin

Michael J. Rynkiewicz, Matthew C. Childers, Olga E. Karpicheva, Michael Regnier, Michael A. Geeves, William Lehman

J Gen Physiol (2024) 156 (5): e202413538.

https://doi.org/10.1085/jgp.202413538

Published: 12 April 2024

View article titled, Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin

Includes: Supplementary data

Journal Articles

Evaluating sequential and allosteric activation models in I_Ks channels with mutated voltage sensors

David Fedida, Daniel Sastre, Ying Dou, Maartje Westhoff, Jodene Eldstrom

J Gen Physiol (2024) 156 (3): e202313465.

https://doi.org/10.1085/jgp.202313465

Published: 31 January 2024

View article titled, Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors

Journal Articles

Elucidating molecular mechanisms of protoxin-II state-specific binding to the human Na_V1.7 channel

Khoa Ngo, Diego Lopez Mateos, Yanxiao Han, Kyle C. Rouen, Surl-Hee Ahn, Heike Wulff, Colleen E. Clancy, Vladimir Yarov-Yarovoy, Igor Vorobyov

J Gen Physiol (2023) 156 (2): e202313368.

https://doi.org/10.1085/jgp.202313368

Published: 21 December 2023

View article titled, Elucidating molecular mechanisms of protoxin-II state-specific binding to the human NaV1.7 channel

Includes: Supplementary data

Journal Articles

Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP

Rong Shen, Benoît Roux, Eduardo Perozo

J Gen Physiol (2023) 156 (1): e202213311.

https://doi.org/10.1085/jgp.202213311

Published: 29 November 2023

View article titled, Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP

Journal Articles

Identifiability of equilibrium constants for receptors with two to five binding sites

Klaus Benndorf, Eckhard Schulz

J Gen Physiol (2023) 155 (12): e202313423.

https://doi.org/10.1085/jgp.202313423

Published: 26 October 2023

View article titled, Identifiability of equilibrium constants for receptors with two to five binding sites

Includes: Supplementary data

Journal Articles

A dual-clock-driven model of lymphatic muscle cell pacemaking to emulate knock-out of Ano1 or IP₃R

Edward J. Hancock, Scott D. Zawieja, Charlie Macaskill, Michael J. Davis, Christopher D. Bertram

J Gen Physiol (2023) 155 (12): e202313355.

https://doi.org/10.1085/jgp.202313355

Published: 18 October 2023

View article titled, A dual-clock-driven model of lymphatic muscle cell pacemaking to emulate knock-out of Ano1 or IP3R

Journal Articles

Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels

In Special Collection:

Molecular Insights into Membrane Protein Function

Denis B. Tikhonov, Boris S. Zhorov

J Gen Physiol (2023) 155 (11): e202313418.

https://doi.org/10.1085/jgp.202313418

Published: 20 September 2023

View article titled, Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels

Journal Articles

Mitochondrial morphology governs ATP production rate

Guadalupe C. Garcia, Kavya Gupta, Thomas M. Bartol, Terrence J. Sejnowski, Padmini Rangamani

J Gen Physiol (2023) 155 (9): e202213263.

https://doi.org/10.1085/jgp.202213263

Published: 24 August 2023

View article titled, Mitochondrial morphology governs ATP production rate

Journal Articles

Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block

Jan H. Krumbach, Daniel Bauer, Atiyeh Sadat Sharifzadeh, Andrea Saponaro, Rene Lautenschläger, Kristina Lange, Oliver Rauh, Dario DiFrancesco, Anna Moroni, Gerhard Thiel, Kay Hamacher

J Gen Physiol (2023) 155 (10): e202313364.

https://doi.org/10.1085/jgp.202313364

Published: 31 July 2023

View article titled, Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block

Includes: Supplementary data

Journal Articles

Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction

Seth H. Weinberg

J Gen Physiol (2023) 155 (8): e202313382.

https://doi.org/10.1085/jgp.202313382

Published: 07 June 2023

View article titled, Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction

Journal Articles

Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations

Anthony Asencio, Sage Malingen, Kristina B. Kooiker, Joseph D. Powers, Jennifer Davis, Thomas Daniel, Farid Moussavi-Harami

J Gen Physiol (2023) 155 (5): e202213291.

https://doi.org/10.1085/jgp.202213291

Published: 31 March 2023

View article titled, Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations

Journal Articles

A cooperative knock-on mechanism underpins Ca²⁺-selective cation permeation in TRPV channels

In Special Collection:

Physiology of Pain Detection and Processing Collection 2023

Callum M. Ives, Neil J. Thomson, Ulrich Zachariae

J Gen Physiol (2023) 155 (5): e202213226.

https://doi.org/10.1085/jgp.202213226

Published: 21 March 2023

View article titled, A cooperative knock-on mechanism underpins Ca2+-selective cation permeation in TRPV channels

Includes: Supplementary data

Journal Articles

Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains

In Special Collection:

Biophysics 2024

Anna Ananchenko, Maria Musgaard

J Gen Physiol (2023) 155 (3): e202213259.

https://doi.org/10.1085/jgp.202213259

Published: 10 January 2023

View article titled, Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains

Journal Articles

Gating and modulation of an inward-rectifier potassium channel

In Special Collection:

Biophysics 2023

Vishwanath Jogini, Morten Ø. Jensen, David E. Shaw

J Gen Physiol (2022) 155 (2): e202213085.

https://doi.org/10.1085/jgp.202213085

Published: 16 December 2022

View article titled, Gating and modulation of an inward-rectifier potassium channel

Includes: Supplementary data

Journal Articles

When is a hydrophobic gate not a hydrophobic gate?

David Seiferth, Philip C. Biggin, Stephen J. Tucker

J Gen Physiol (2022) 154 (11): e202213210.

https://doi.org/10.1085/jgp.202213210

Published: 26 October 2022

View article titled, When is a hydrophobic gate not a hydrophobic gate?

Journal Articles

Disorder in Ca²⁺ release unit locations confers robustness but cuts flexibility of heart pacemaking

Anna V. Maltsev, Michael D. Stern, Victor A. Maltsev

J Gen Physiol (2022) 154 (9): e202113061.

https://doi.org/10.1085/jgp.202113061

Published: 09 August 2022

View article titled, Disorder in Ca2+ release unit locations confers robustness but cuts flexibility of heart pacemaking

Includes: Supplementary data

Journal Articles

Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific

Niklas Brake, Adamo S. Mancino, Yuhao Yan, Takushi Shimomura, Yoshihiro Kubo, Anmar Khadra, Derek Bowie

J Gen Physiol (2022) 154 (7): e202112921.

https://doi.org/10.1085/jgp.202112921

Published: 25 May 2022

View article titled, Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific

Includes: Supplementary data

NARROW

Mathematical modeling of intracellular osmolarity and cell volume stabilization: The Donnan effect and ion transport

Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue

Fusion pore flux controls the rise-times of quantal synaptic responses

Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin

Evaluating sequential and allosteric activation models in I_Ks channels with mutated voltage sensors

Elucidating molecular mechanisms of protoxin-II state-specific binding to the human Na_V1.7 channel

Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP

Identifiability of equilibrium constants for receptors with two to five binding sites

A dual-clock-driven model of lymphatic muscle cell pacemaking to emulate knock-out of Ano1 or IP₃R

Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels

Mitochondrial morphology governs ATP production rate

Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block

Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction

Machine learning meets Monte Carlo methods for models of muscle’s molecular machinery to classify mutations

A cooperative knock-on mechanism underpins Ca²⁺-selective cation permeation in TRPV channels

Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains

Gating and modulation of an inward-rectifier potassium channel

When is a hydrophobic gate not a hydrophobic gate?

Disorder in Ca²⁺ release unit locations confers robustness but cuts flexibility of heart pacemaking

Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific

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