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Journal Articles

Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K⁺ channels

Benjamin T. Simonson, Zhaoyang Jiang, Joseph F. Ryan, Timothy Jegla

J Gen Physiol (2025) 157 (3): e202413740.

https://doi.org/10.1085/jgp.202413740

Published: 18 March 2025

View articletitled, Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels

Includes: Supplementary data

Journal Articles

Novel Ca²⁺ wave mechanisms in cardiac myocytes revealed by multiscale Ca²⁺ release model

Morris Vysma, James S. Welsh, Derek R. Laver

J Gen Physiol (2025) 157 (3): e202413543.

https://doi.org/10.1085/jgp.202413543

Published: 06 March 2025

View articletitled, Novel Ca2+ wave mechanisms in cardiac myocytes revealed by multiscale Ca2+ release model

Includes: Supplementary data

Journal Articles

The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses

Wallace B. Thoreson, Thomas M. Bartol, Nicholas H. Conoan, Jeffrey S. Diamond

J Gen Physiol (2025) 157 (3): e202413746.

https://doi.org/10.1085/jgp.202413746

Published: 28 February 2025

View articletitled, The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses

Journal Articles

In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel

Alp Tegin Şahin, Ulrich Zachariae

J Gen Physiol (2025) 157 (3): e202313506.

https://doi.org/10.1085/jgp.202313506

Published: 21 February 2025

View articletitled, In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel

Includes: Supplementary data

Journal Articles

Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease

Maya Noureddine, Halina Mikolajek, Neil V. Morgan, Chris Denning, Siobhan Loughna, Katja Gehmlich, Fiyaz Mohammed

J Gen Physiol (2025) 157 (2): e202413684.

https://doi.org/10.1085/jgp.202413684

Published: 07 February 2025

View articletitled, Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease

Includes: Supplementary data

Journal Articles

Mechanisms underlying the distinct K⁺ dependencies of periodic paralysis

Brent D. Foy, Chris Dupont, Phillip V. Walker, II, Kirsten Denman, Kathrin L. Engisch, Mark M. Rich

J Gen Physiol (2025) 157 (3): e202413610.

https://doi.org/10.1085/jgp.202413610

Published: 04 February 2025

View articletitled, Mechanisms underlying the distinct K+ dependencies of periodic paralysis

Includes: Supplementary data

Journal Articles

Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium

Tuan A. Phan, Daniel P. Fitzsimons

J Gen Physiol (2025) 157 (2): e202413582.

https://doi.org/10.1085/jgp.202413582

Published: 27 January 2025

View articletitled, Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium

Includes: Supplementary data

Journal Articles

The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels

Eslam Elhanafy, Amin Akbari Ahangar, Rebecca Roth, Tamer M. Gamal El-Din, John R. Bankston, Jing Li

J Gen Physiol (2025) 157 (2): e202413669.

https://doi.org/10.1085/jgp.202413669

Published: 17 January 2025

View articletitled, The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels

Includes: Supplementary data

Journal Articles

Drugs exhibit diverse binding modes and access routes in the Na_v1.5 cardiac sodium channel pore

Elaine Tao, Ben Corry

J Gen Physiol (2025) 157 (2): e202413658.

https://doi.org/10.1085/jgp.202413658

Published: 07 January 2025

View articletitled, Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore

Journal Articles

Isoform-specific N-linked glycosylation of Na_V channel α-subunits alters β-subunit binding sites

Christopher A. Beaudoin, Manas Kohli, Samantha C. Salvage, Hengrui Liu, Samuel J. Arundel, Samir W. Hamaia, Ming Lei, Christopher L.-H. Huang, Antony P. Jackson

J Gen Physiol (2024) 157 (1): e202413609.

https://doi.org/10.1085/jgp.202413609

Published: 16 December 2024

View articletitled, Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites

Journal Articles

A sodium channel mutant removes fast inactivation with the inactivation particle bound

Yichen Liu, Francisco Bezanilla

J Gen Physiol (2024) 157 (1): e202413667.

https://doi.org/10.1085/jgp.202413667

Published: 27 November 2024

View articletitled, A sodium channel mutant removes fast inactivation with the inactivation particle bound

Includes: Supplementary data

Journal Articles

Interplay of Na_v1.8 and Na_v1.7 channels drives neuronal hyperexcitability in neuropathic pain

Dmytro V. Vasylyev, Peng Zhao, Betsy R. Schulman, Stephen G. Waxman

J Gen Physiol (2024) 156 (11): e202413596.

https://doi.org/10.1085/jgp.202413596

Published: 08 October 2024

View articletitled, Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain

Includes: Supplementary data

Journal Articles

Using neural networks for image analysis in general physiology

Eduardo Rios

J Gen Physiol (2024) 156 (10): e202413623.

https://doi.org/10.1085/jgp.202413623

Published: 17 September 2024

View articletitled, Using neural networks for image analysis in general physiology

Journal Articles

Mathematical modeling of intracellular osmolarity and cell volume stabilization: The Donnan effect and ion transport

Zahra Aminzare, Alan R. Kay

J Gen Physiol (2024) 156 (8): e202413554.

https://doi.org/10.1085/jgp.202413554

Published: 12 July 2024

View articletitled, Mathematical modeling of intracellular osmolarity and cell volume stabilization: The Donnan effect and ion transport

Journal Articles

Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue

Eduardo Ríos, Montserrat Samsó, Lourdes C. Figueroa, Carlo Manno, Eshwar R. Tammineni, Lucas Rios Giordano, Sheila Riazi

J Gen Physiol (2024) 156 (9): e202413595.

https://doi.org/10.1085/jgp.202413595

Published: 09 July 2024

View articletitled, Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue

Includes: Supplementary data

Journal Articles

Fusion pore flux controls the rise-times of quantal synaptic responses

In Special Collection:

Molecular Insights into Membrane Protein Function

Meyer B. Jackson, Chung-Wei Chiang, Jinbo Cheng

J Gen Physiol (2024) 156 (8): e202313484.

https://doi.org/10.1085/jgp.202313484

Published: 11 June 2024

View articletitled, Fusion pore flux controls the rise-times of quantal synaptic responses

Journal Articles

Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin

Michael J. Rynkiewicz, Matthew C. Childers, Olga E. Karpicheva, Michael Regnier, Michael A. Geeves, William Lehman

J Gen Physiol (2024) 156 (5): e202413538.

https://doi.org/10.1085/jgp.202413538

Published: 12 April 2024

View articletitled, Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin

Includes: Supplementary data

Journal Articles

Evaluating sequential and allosteric activation models in I_Ks channels with mutated voltage sensors

David Fedida, Daniel Sastre, Ying Dou, Maartje Westhoff, Jodene Eldstrom

J Gen Physiol (2024) 156 (3): e202313465.

https://doi.org/10.1085/jgp.202313465

Published: 31 January 2024

View articletitled, Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors

Journal Articles

Elucidating molecular mechanisms of protoxin-II state-specific binding to the human Na_V1.7 channel

Khoa Ngo, Diego Lopez Mateos, Yanxiao Han, Kyle C. Rouen, Surl-Hee Ahn, Heike Wulff, Colleen E. Clancy, Vladimir Yarov-Yarovoy, Igor Vorobyov

J Gen Physiol (2023) 156 (2): e202313368.

https://doi.org/10.1085/jgp.202313368

Published: 21 December 2023

View articletitled, Elucidating molecular mechanisms of protoxin-II state-specific binding to the human NaV1.7 channel

Includes: Supplementary data

Journal Articles

Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP

Rong Shen, Benoît Roux, Eduardo Perozo

J Gen Physiol (2023) 156 (1): e202213311.

https://doi.org/10.1085/jgp.202213311

Published: 29 November 2023

View articletitled, Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP

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Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K⁺ channels

Novel Ca²⁺ wave mechanisms in cardiac myocytes revealed by multiscale Ca²⁺ release model

The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses

In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel

Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease

Mechanisms underlying the distinct K⁺ dependencies of periodic paralysis

Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium

The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels

Drugs exhibit diverse binding modes and access routes in the Na_v1.5 cardiac sodium channel pore

Isoform-specific N-linked glycosylation of Na_V channel α-subunits alters β-subunit binding sites

A sodium channel mutant removes fast inactivation with the inactivation particle bound

Interplay of Na_v1.8 and Na_v1.7 channels drives neuronal hyperexcitability in neuropathic pain

Using neural networks for image analysis in general physiology

Mathematical modeling of intracellular osmolarity and cell volume stabilization: The Donnan effect and ion transport

Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue

Fusion pore flux controls the rise-times of quantal synaptic responses

Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin

Evaluating sequential and allosteric activation models in I_Ks channels with mutated voltage sensors

Elucidating molecular mechanisms of protoxin-II state-specific binding to the human Na_V1.7 channel

Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP

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