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Journal Articles

Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2

Diego Lopez-Mateos, Kush Narang, Vladimir Yarov-Yarovoy

J Gen Physiol (2025) 158 (2): e202413705.

https://doi.org/10.1085/jgp.202413705

Published: 18 December 2025

View article titled, Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2

Includes: Supplementary data

Journal Articles

Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?

Eduardo Rios

J Gen Physiol (2025) 158 (1): e202513877.

https://doi.org/10.1085/jgp.202513877

Published: 17 December 2025

View article titled, Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?

Journal Articles

Cortical spreading depression dynamics are altered by topical D2 receptor ligands

Sonia Carolina Guerrero Prieto, Michael Cabrera Baez, Rubem Carlos Araújo Guedes

J Gen Physiol (2025) 157 (6): e202513843.

https://doi.org/10.1085/jgp.202513843

Published: 07 October 2025

View article titled, Cortical spreading depression dynamics are altered by topical D2 receptor ligands

Journal Articles

GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle

Bin Sun, Alec Loftus, Brandon Beh Goh Beh, Aalaythia Hepburn, Jonathan A. Kirk, Peter M. Kekenes-Huskey

J Gen Physiol (2025) 157 (5): e202413737.

https://doi.org/10.1085/jgp.202413737

Published: 26 August 2025

View article titled, GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle

Includes: Supplementary data

Journal Articles

Exploring a peripheral PIP₂-binding site and its role in the alternative regulation of the TRP channel superfamily

L. Gonzalo Espinoza-Arcos, Mariela González-Avendaño, Matías Zuñiga-Bustos, Ricardo A. Zamora, Ariela Vergara-Jaque, Horacio Poblete

J Gen Physiol (2025) 157 (6): e202413574.

https://doi.org/10.1085/jgp.202413574

Published: 22 August 2025

View article titled, Exploring a peripheral PIP2-binding site and its role in the alternative regulation of the TRP channel superfamily

Includes: Supplementary data

Journal Articles

Variability in reported midpoints of (in)activation of cardiac I_Na

Michael Clerx, Paul G.A. Volders, Gary R. Mirams

J Gen Physiol (2025) 157 (5): e202413621.

https://doi.org/10.1085/jgp.202413621

Published: 16 July 2025

View article titled, Variability in reported midpoints of (in)activation of cardiac INa

Includes: Supplementary data

Journal Articles

Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44

David Gong, Jennifer L. Orthmann-Murphy, Deepak Kumar, Gabriel D. Dungan, Ayman W. El-Hattab, Nicoline Schiess, Yun L. Luo, Mona M. Freidin, Charles K. Abrams

J Gen Physiol (2025) 157 (4): e202413617.

https://doi.org/10.1085/jgp.202413617

Published: 10 June 2025

View article titled, Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44

Includes: Supplementary data

Journal Articles

Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K⁺ channels

Benjamin T. Simonson, Zhaoyang Jiang, Joseph F. Ryan, Timothy Jegla

J Gen Physiol (2025) 157 (3): e202413740.

https://doi.org/10.1085/jgp.202413740

Published: 18 March 2025

View article titled, Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels

Includes: Supplementary data

Journal Articles

Novel Ca²⁺ wave mechanisms in cardiac myocytes revealed by multiscale Ca²⁺ release model

Morris Vysma, James S. Welsh, Derek R. Laver

J Gen Physiol (2025) 157 (3): e202413543.

https://doi.org/10.1085/jgp.202413543

Published: 06 March 2025

View article titled, Novel Ca2+ wave mechanisms in cardiac myocytes revealed by multiscale Ca2+ release model

Includes: Supplementary data

Journal Articles

The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses

In Special Collection:

Neuroscience Collection 2025

Wallace B. Thoreson, Thomas M. Bartol, Nicholas H. Conoan, Jeffrey S. Diamond

J Gen Physiol (2025) 157 (3): e202413746.

https://doi.org/10.1085/jgp.202413746

Published: 28 February 2025

View article titled, The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses

Journal Articles

In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel

Alp Tegin Şahin, Ulrich Zachariae

J Gen Physiol (2025) 157 (3): e202313506.

https://doi.org/10.1085/jgp.202313506

Published: 21 February 2025

View article titled, In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel

Includes: Supplementary data

Journal Articles

Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease

Maya Noureddine, Halina Mikolajek, Neil V. Morgan, Chris Denning, Siobhan Loughna, Katja Gehmlich, Fiyaz Mohammed

J Gen Physiol (2025) 157 (2): e202413684.

https://doi.org/10.1085/jgp.202413684

Published: 07 February 2025

View article titled, Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease

Includes: Supplementary data

Journal Articles

Mechanisms underlying the distinct K⁺ dependencies of periodic paralysis

Brent D. Foy, Chris Dupont, Phillip V. Walker, II, Kirsten Denman, Kathrin L. Engisch, Mark M. Rich

J Gen Physiol (2025) 157 (3): e202413610.

https://doi.org/10.1085/jgp.202413610

Published: 04 February 2025

View article titled, Mechanisms underlying the distinct K+ dependencies of periodic paralysis

Includes: Supplementary data

Journal Articles

Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium

Tuan A. Phan, Daniel P. Fitzsimons

J Gen Physiol (2025) 157 (2): e202413582.

https://doi.org/10.1085/jgp.202413582

Published: 27 January 2025

View article titled, Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium

Includes: Supplementary data

Journal Articles

The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels

Eslam Elhanafy, Amin Akbari Ahangar, Rebecca Roth, Tamer M. Gamal El-Din, John R. Bankston, Jing Li

J Gen Physiol (2025) 157 (2): e202413669.

https://doi.org/10.1085/jgp.202413669

Published: 17 January 2025

View article titled, The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels

Includes: Supplementary data

Journal Articles

Drugs exhibit diverse binding modes and access routes in the Na_v1.5 cardiac sodium channel pore

Elaine Tao, Ben Corry

J Gen Physiol (2025) 157 (2): e202413658.

https://doi.org/10.1085/jgp.202413658

Published: 07 January 2025

View article titled, Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore

Journal Articles

Isoform-specific N-linked glycosylation of Na_V channel α-subunits alters β-subunit binding sites

In Special Collection:

JGP Highlights Collection 2025

Christopher A. Beaudoin, Manas Kohli, Samantha C. Salvage, Hengrui Liu, Samuel J. Arundel, Samir W. Hamaia, Ming Lei, Christopher L.-H. Huang, Antony P. Jackson

J Gen Physiol (2024) 157 (1): e202413609.

https://doi.org/10.1085/jgp.202413609

Published: 16 December 2024

View article titled, Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites

Journal Articles

A sodium channel mutant removes fast inactivation with the inactivation particle bound

In Special Collection:

JGP Highlights Collection 2025

Yichen Liu, Francisco Bezanilla

J Gen Physiol (2024) 157 (1): e202413667.

https://doi.org/10.1085/jgp.202413667

Published: 27 November 2024

View article titled, A sodium channel mutant removes fast inactivation with the inactivation particle bound

Includes: Supplementary data

Journal Articles

Interplay of Na_v1.8 and Na_v1.7 channels drives neuronal hyperexcitability in neuropathic pain

In Special Collection:

Neuroscience Collection 2025

Dmytro V. Vasylyev, Peng Zhao, Betsy R. Schulman, Stephen G. Waxman

J Gen Physiol (2024) 156 (11): e202413596.

https://doi.org/10.1085/jgp.202413596

Published: 08 October 2024

View article titled, Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain

Includes: Supplementary data

Journal Articles

Using neural networks for image analysis in general physiology

Eduardo Rios

J Gen Physiol (2024) 156 (10): e202413623.

https://doi.org/10.1085/jgp.202413623

Published: 17 September 2024

View article titled, Using neural networks for image analysis in general physiology

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Date

Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2

Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?

Cortical spreading depression dynamics are altered by topical D2 receptor ligands

GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle

Exploring a peripheral PIP₂-binding site and its role in the alternative regulation of the TRP channel superfamily

Variability in reported midpoints of (in)activation of cardiac I_Na

Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44

Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K⁺ channels

Novel Ca²⁺ wave mechanisms in cardiac myocytes revealed by multiscale Ca²⁺ release model

The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses

In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel

Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease

Mechanisms underlying the distinct K⁺ dependencies of periodic paralysis

Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium

The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels

Drugs exhibit diverse binding modes and access routes in the Na_v1.5 cardiac sodium channel pore

Isoform-specific N-linked glycosylation of Na_V channel α-subunits alters β-subunit binding sites

A sodium channel mutant removes fast inactivation with the inactivation particle bound

Interplay of Na_v1.8 and Na_v1.7 channels drives neuronal hyperexcitability in neuropathic pain

Using neural networks for image analysis in general physiology

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