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Journal Articles

Equivalent gain-of-function variants in KCNK3 and KCNK9 and their contribution to distinct TASK K2P channelopathies

Kate M. Crowther, Thibault R.H. Jouen-Tachoire, Peter Proks, Peter Rory Hall, Emma L. Veale, Janina Sörmann, Karin E.J. Rödström, Thomas Müller, Saskia B. Wortmann, Nina Barisic, Natalie Hauser, Vincenzo Salpietro, RaeLynn Forsyth, Linford Williams, Nora Derrabi, Carlos A. Bacino, Jill A. Rosenfeld, Henry Houlden, Simon Newstead, Caroline F. Wright, James Fasham, Alistair A. Mathie, Reza Maroofian, Stephen J. Tucker
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (5): e202613989.
https://doi.org/10.1085/jgp.202613989
Published: 06 August 2026
View article titled, Equivalent gain-of-function variants in KCNK3 and KCNK9 and their contribution to distinct TASK K2P channelopathies
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Includes: Supplementary data
Journal Articles

Reorganization of the slide helix by cholesterol during KirBac1.1 channel inactivation in membranes

Arpan Bysack, H. Raghuraman
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (5): e202614000.
https://doi.org/10.1085/jgp.202614000
Published: 06 August 2026
View article titled, Reorganization of the slide helix by cholesterol during KirBac1.1 channel inactivation in membranes
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Includes: Supplementary data
Journal Articles

Differential Na+ chelation underlies opposite effects of aconitine and bulleyaconitine on sodium channel permeation

In Special Collection:
Voltage-Gated Na Channels 2026
Boris S. Zhorov
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels 2026
J Gen Physiol (2026) 158 (5): e202614023.
https://doi.org/10.1085/jgp.202614023
Published: 06 August 2026
View article titled, Differential Na+ chelation underlies opposite effects of aconitine and bulleyaconitine on sodium channel permeation
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Journal Articles

Allosteric interactions between RyR channels justify intracellular Ca2+ release of skeletal muscle in quantitative detail

Eduardo Rios, Gonzalo Pizarro
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202613968.
https://doi.org/10.1085/jgp.202613968
Published: 21 July 2026
View article titled, Allosteric interactions between RyR channels justify intracellular Ca2+ release of skeletal muscle in quantitative detail
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Journal Articles

Electrophysiology in nanoscale compartments

Madeleine R. Howell, Rosalind J. Xu, Adam E. Cohen
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202614011.
https://doi.org/10.1085/jgp.202614011
Published: 20 July 2026
View article titled, Electrophysiology in nanoscale compartments
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Includes: Supplementary data
Journal Articles

Model prokaryotic potassium channels: Predictive power and relevance to eukaryotic channels

Philipp A.M. Schmidpeter, Crina M. Nimigean
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202614025.
https://doi.org/10.1085/jgp.202614025
Published: 09 July 2026
View article titled, Model prokaryotic potassium channels: Predictive power and relevance to eukaryotic channels
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Journal Articles

Evolution, hibernation, and inactivation of voltage-gated Na channels

John S. Willis
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (5): e202513923.
https://doi.org/10.1085/jgp.202513923
Published: 07 July 2026
View article titled, Evolution, hibernation, and inactivation of voltage-gated Na channels
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Journal Articles

On the mechanism of hypomagnesemia with treatment-resistant seizures caused by variants of the Na+,K+-ATPase α1 subunit (ATP1A1)

Nicolas Colmano, Daniel Self, Hang N. Nielsen, Rikke Holm, Chai C. Gopalasingam, Ryota Fujimura, Kazuhiro Abe, Bente Vilsen, Sho T. Yano, Pablo Artigas
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202513959.
https://doi.org/10.1085/jgp.202513959
Published: 30 June 2026
View article titled, On the mechanism of hypomagnesemia with treatment-resistant seizures caused by variants of the Na+,K+-ATPase α1 subunit (ATP1A1)
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Includes: Supplementary data
Journal Articles

Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV

In Special Collection:
Voltage-Gated Na Channels 2026
Maxime Lammens, Jolien De Waele, Alain J. Labro, Filip Van Petegem, Frank Bosmans
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels 2026
J Gen Physiol (2026) 158 (5): e202614018.
https://doi.org/10.1085/jgp.202614018
Published: 29 June 2026
View article titled, Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV
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Journal Articles

An epilepsy-associated KV3.1 potassium channel variant acts via dominant-positive effect

Jerome Clatot, Hubert Monnerie, Axel Panzer, Konrad Platzer, Ethan M. Goldberg
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (5): e202513962.
https://doi.org/10.1085/jgp.202513962
Published: 25 June 2026
View article titled, An epilepsy-associated KV3.1 potassium channel variant acts via dominant-positive effect
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Journal Articles

Regulation of olfactory chloride and cyclic nucleotide–gated channels by cholesterol

Samsudeen Ponissery Saidu, Alexander Kross, Michele Dibattista, Katharina Gaus, Johannes Reisert
Journal: Journal of General Physiology
Series: Chloride Channels and Transporters
J Gen Physiol (2026) 158 (4): e202513963.
https://doi.org/10.1085/jgp.202513963
Published: 23 June 2026
View article titled, Regulation of olfactory chloride and cyclic nucleotide–gated channels by cholesterol
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Journal Articles

Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions

Sofia F. Nazarova, Vadim A. Alekhin, Vladislav V. Pavlov, Yury S. Semenov, Siarhei M. Bukhalovich, Fedor M. Tsybrov, Andrey O. Bogorodskiy, Diana F. Bagaeva, Olga V. Moiseeva, Anastasiia D. Vlasova, Anatolii E. Mikhailov, Yayu Wang, Andrey V. Rogachev, Semen V. Nesterov, Valentin I. Borshchevskiy, Chunlei Cang, Piotr D. Bregestovski, Valentin I. Gordeliy, Nikolay S. Ilyinsky
Journal: Journal of General Physiology
Series: Molecular evolution in the membrane
J Gen Physiol (2026) 158 (4): e202413745.
https://doi.org/10.1085/jgp.202413745
Published: 18 June 2026
View article titled, Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions
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Includes: Supplementary data
Journal Articles

Vesicular monoamine transporters (VMATs): From discovery to therapeutic targets

Shimon Schuldiner
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (4): e202614012.
https://doi.org/10.1085/jgp.202614012
Published: 08 June 2026
View article titled, Vesicular monoamine transporters (VMATs): From discovery to therapeutic targets
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Includes: Supplementary data
Journal Articles

Long-term inactivation mediated by different FGF-A homologues on heterologously expressed NaV1.2 currents

In Special Collection:
Voltage-Gated Na Channels 2026
Yenisleidy Lorenzo-Ceballos, Pedro L. Martinez-Espinosa, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels 2026
J Gen Physiol (2026) 158 (4): e202613985.
https://doi.org/10.1085/jgp.202613985
Published: 22 May 2026
View article titled, Long-term inactivation mediated by different FGF-A homologues on heterologously expressed NaV1.2 currents
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Includes: Supplementary data
Journal Articles

Evolution of our understanding of the sodium channel fast inactivation: From Hodgkin and Huxley to the structural era

In Special Collection:
Voltage-Gated Na Channels 2026
Yichen Liu, Cesar A. Amaya-Rodriguez, Victoria Collio, Gabriel Ibañez, Ramón Latorre, Francisco Bezanilla
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels 2026
J Gen Physiol (2026) 158 (4): e202613980.
https://doi.org/10.1085/jgp.202613980
Published: 07 May 2026
View article titled, Evolution of our understanding of the sodium channel fast inactivation: From Hodgkin and Huxley to the structural era
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Journal Articles

Calmodulinopathy variants impair CaV1.3 and CaV2.1 regulation

John W. Hussey, Emily DeMarco, Deborah DiSilvestre, Malene Brohus, Ana-Octavia Busuioc, Emil D. Iversen, Helene H. Jensen, Mette Nyegaard, Michael T. Overgaard, Manu Ben-Johny, Ivy E. Dick
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202413734.
https://doi.org/10.1085/jgp.202413734
Published: 24 April 2026
View article titled, Calmodulinopathy variants impair CaV1.3 and CaV2.1 regulation
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Includes: Supplementary data
Journal Articles

Distinctive mechanical response characteristics of the guinea pig apical cochlear organ of Corti and basilar membrane

George W.S. Burwood, Tianying Ren, Edward V. Porsov, Alfred L. Nuttall, Anders Fridberger
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202413611.
https://doi.org/10.1085/jgp.202413611
Published: 21 April 2026
View article titled, Distinctive mechanical response characteristics of the guinea pig apical cochlear organ of Corti and basilar membrane
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Includes: Supplementary data
Journal Articles

Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons

Lucas J. Handlin, Clémence Gieré, Nicolas L.A. Dumaire, Lyuba Salih, Aubin Moutal, Gucan Dai
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202513925.
https://doi.org/10.1085/jgp.202513925
Published: 12 March 2026
View article titled, Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons
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Includes: Supplementary data
Journal Articles

Opening of rod photoreceptor CNG channels by photodynamically generated singlet oxygen

Gaogao He, Xiaoxi Li, Yanlin Huang, Conghan Wang, Minjie Tan, Qinglian Liu, Lei Zhou
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202513819.
https://doi.org/10.1085/jgp.202513819
Published: 05 March 2026
View article titled, Opening of rod photoreceptor CNG channels by photodynamically generated singlet oxygen
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Journal Articles

Post-translational modifications of cardiac myosin-binding protein-C: Mechanisms behind fine-tuning the sarcomere

Angela C. Greenman, Willem de Lange, J. Carter Ralphe
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202513889.
https://doi.org/10.1085/jgp.202513889
Published: 03 March 2026
View article titled, Post-translational modifications of cardiac myosin-binding protein-C: Mechanisms behind fine-tuning the sarcomere
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