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Journal Articles

A fluorescent non-hydrolyzable probe for the nucleotide-binding sites of KATP

Priscilla Rubio, Shayla Q. Whitaker, Jonathan Ashby, Michael C. Puljung
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (6): e202513840.
https://doi.org/10.1085/jgp.202513840
Published: 18 September 2026
View article titled, A fluorescent non-hydrolyzable probe for the nucleotide-binding sites of KATP
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Journal Articles

The proximal N terminus of IRAG is required for potentiation of HCN4 channels

Lucas M. Blecker, Emily M. Teichman, Colin H. Peters, Daniel J. Enders, Rebecca Roth, William G. Nichols, Avery A. Langley, Catherine Proenza, John R. Bankston
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (6): e202614032.
https://doi.org/10.1085/jgp.202614032
Published: 10 September 2026
View article titled, The proximal N terminus of IRAG is required for potentiation of HCN4 channels
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Includes: Supplementary data
Journal Articles

The many faces of Orai1 dysfunction: Molecular mechanisms and clinical manifestations

Magdalena Prantl, Lara Atzgerstorfer, Tamara Radiskovic, Marc Fahrner, Isabella Derler
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (6): e202614031.
https://doi.org/10.1085/jgp.202614031
Published: 31 August 2026
View article titled, The many faces of Orai1 dysfunction: Molecular mechanisms and clinical manifestations
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Journal Articles

Tunable AMPA receptor function via recurrent evolution of heterotetramers

Yuhong Wang, Alexander Edwards, Jelena Baranovic, Timothy Lynagh
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (6): e202614039.
https://doi.org/10.1085/jgp.202614039
Published: 27 August 2026
View article titled, Tunable AMPA receptor function via recurrent evolution of heterotetramers
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Includes: Supplementary data
Journal Articles

Characterization of an open-channel structure and lateral conduction pathway in the cation-selective pentameric ligand-gated ion channel, ELIC

Mark J. Arcario, Elizabeth J. Wu-Chen, Yuna Shim, Jérôme Hénin, Grace Brannigan, Wayland W.L. Cheng
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202513926.
https://doi.org/10.1085/jgp.202513926
Published: 27 August 2026
View article titled, Characterization of an open-channel structure and lateral conduction pathway in the cation-selective pentameric ligand-gated ion channel, ELIC
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Journal Articles

A hERG blocker facilitates K+ channel current by promoting pore opening while blocking

Steffen S. Docken, Matthew J. Marquis, Khoa Ngo, Yuumu Wada, Satomi Kita, Vladimir Yarov-Yarovoy, Colleen E. Clancy, Igor Vorobyov, Timothy J. Lewis, Kazuharu Furutani, Jon T. Sack
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (6): e202614015.
https://doi.org/10.1085/jgp.202614015
Published: 27 August 2026
View article titled, A hERG blocker facilitates K+ channel current by promoting pore opening while blocking
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Journal Articles

A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions

Ryan J. Farrell, S. Thomas Hennigan, Kirsten G. Bredvik, Michael B. Hoppa, Timothy A. Brown, Timothy A. Ryan
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202413564.
https://doi.org/10.1085/jgp.202413564
Published: 19 August 2026
View article titled, A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions
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Journal Articles

Equivalent gain-of-function variants in KCNK3 and KCNK9 and their contribution to distinct TASK K2P channelopathies

Kate M. Crowther, Thibault R.H. Jouen-Tachoire, Peter Proks, Peter Rory Hall, Emma L. Veale, Janina Sörmann, Karin E.J. Rödström, Thomas Müller, Saskia B. Wortmann, Nina Barisic, Natalie Hauser, Vincenzo Salpietro, RaeLynn Forsyth, Linford Williams, Nora Derrabi, Carlos A. Bacino, Jill A. Rosenfeld, Henry Houlden, Simon Newstead, Caroline F. Wright, James Fasham, Alistair A. Mathie, Reza Maroofian, Stephen J. Tucker
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (5): e202613989.
https://doi.org/10.1085/jgp.202613989
Published: 06 August 2026
View article titled, Equivalent gain-of-function variants in KCNK3 and KCNK9 and their contribution to distinct TASK K2P channelopathies
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Includes: Supplementary data
Journal Articles

Reorganization of the slide helix by cholesterol during KirBac1.1 channel inactivation in membranes

Arpan Bysack, H. Raghuraman
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (5): e202614000.
https://doi.org/10.1085/jgp.202614000
Published: 06 August 2026
View article titled, Reorganization of the slide helix by cholesterol during KirBac1.1 channel inactivation in membranes
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Includes: Supplementary data
Journal Articles

Differential Na+ chelation underlies opposite effects of aconitine and bulleyaconitine on sodium channel permeation

In Special Collection:
Voltage-Gated Na Channels 2026
Boris S. Zhorov
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels 2026
J Gen Physiol (2026) 158 (5): e202614023.
https://doi.org/10.1085/jgp.202614023
Published: 06 August 2026
View article titled, Differential Na+ chelation underlies opposite effects of aconitine and bulleyaconitine on sodium channel permeation
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Journal Articles

Allosteric interactions between RyR channels justify intracellular Ca2+ release of skeletal muscle in quantitative detail

Eduardo Rios, Gonzalo Pizarro
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202613968.
https://doi.org/10.1085/jgp.202613968
Published: 21 July 2026
View article titled, Allosteric interactions between RyR channels justify intracellular Ca2+ release of skeletal muscle in quantitative detail
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Journal Articles

Electrophysiology in nanoscale compartments

Madeleine R. Howell, Rosalind J. Xu, Adam E. Cohen
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202614011.
https://doi.org/10.1085/jgp.202614011
Published: 20 July 2026
View article titled, Electrophysiology in nanoscale compartments
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Includes: Supplementary data
Journal Articles

Model prokaryotic potassium channels: Predictive power and relevance to eukaryotic channels

Philipp A.M. Schmidpeter, Crina M. Nimigean
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202614025.
https://doi.org/10.1085/jgp.202614025
Published: 09 July 2026
View article titled, Model prokaryotic potassium channels: Predictive power and relevance to eukaryotic channels
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Journal Articles

Evolution, hibernation, and inactivation of voltage-gated Na channels

John S. Willis
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (5): e202513923.
https://doi.org/10.1085/jgp.202513923
Published: 07 July 2026
View article titled, Evolution, hibernation, and inactivation of voltage-gated Na channels
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Journal Articles

On the mechanism of hypomagnesemia with treatment-resistant seizures caused by variants of the Na+,K+-ATPase α1 subunit (ATP1A1)

Nicolas Colmano, Daniel Self, Hang N. Nielsen, Rikke Holm, Chai C. Gopalasingam, Ryota Fujimura, Kazuhiro Abe, Bente Vilsen, Sho T. Yano, Pablo Artigas
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202513959.
https://doi.org/10.1085/jgp.202513959
Published: 30 June 2026
View article titled, On the mechanism of hypomagnesemia with treatment-resistant seizures caused by variants of the Na+,K+-ATPase α1 subunit (ATP1A1)
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Includes: Supplementary data
Journal Articles

Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV

In Special Collection:
Voltage-Gated Na Channels 2026
Maxime Lammens, Jolien De Waele, Alain J. Labro, Filip Van Petegem, Frank Bosmans
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels 2026
J Gen Physiol (2026) 158 (5): e202614018.
https://doi.org/10.1085/jgp.202614018
Published: 29 June 2026
View article titled, Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV
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Journal Articles

An epilepsy-associated KV3.1 potassium channel variant acts via dominant-positive effect

Jerome Clatot, Hubert Monnerie, Axel Panzer, Konrad Platzer, Ethan M. Goldberg
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (5): e202513962.
https://doi.org/10.1085/jgp.202513962
Published: 25 June 2026
View article titled, An epilepsy-associated KV3.1 potassium channel variant acts via dominant-positive effect
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Journal Articles

Regulation of olfactory chloride and cyclic nucleotide–gated channels by cholesterol

Samsudeen Ponissery Saidu, Alexander Kross, Michele Dibattista, Katharina Gaus, Johannes Reisert
Journal: Journal of General Physiology
Series: Chloride Channels and Transporters
J Gen Physiol (2026) 158 (4): e202513963.
https://doi.org/10.1085/jgp.202513963
Published: 23 June 2026
View article titled, Regulation of olfactory chloride and cyclic nucleotide–gated channels by cholesterol
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Journal Articles

Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions

Sofia F. Nazarova, Vadim A. Alekhin, Vladislav V. Pavlov, Yury S. Semenov, Siarhei M. Bukhalovich, Fedor M. Tsybrov, Andrey O. Bogorodskiy, Diana F. Bagaeva, Olga V. Moiseeva, Anastasiia D. Vlasova, Anatolii E. Mikhailov, Yayu Wang, Andrey V. Rogachev, Semen V. Nesterov, Valentin I. Borshchevskiy, Chunlei Cang, Piotr D. Bregestovski, Valentin I. Gordeliy, Nikolay S. Ilyinsky
Journal: Journal of General Physiology
Series: Molecular evolution in the membrane
J Gen Physiol (2026) 158 (4): e202413745.
https://doi.org/10.1085/jgp.202413745
Published: 18 June 2026
View article titled, Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions
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Includes: Supplementary data
Journal Articles

Vesicular monoamine transporters (VMATs): From discovery to therapeutic targets

Shimon Schuldiner
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (4): e202614012.
https://doi.org/10.1085/jgp.202614012
Published: 08 June 2026
View article titled, Vesicular monoamine transporters (VMATs): From discovery to therapeutic targets
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Includes: Supplementary data

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