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Regulation of olfactory chloride and cyclic nucleotide–gated channels by cholesterol

Samsudeen Ponissery Saidu, Alexander Kross, Michele Dibattista, Katharina Gaus, Johannes Reisert

J Gen Physiol (2026) 158 (4): e202513963.

https://doi.org/10.1085/jgp.202513963

Published: 23 June 2026

View article titled, Regulation of olfactory chloride and cyclic nucleotide–gated channels by cholesterol

Journal Articles

Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions

Sofia F. Nazarova, Vadim A. Alekhin, Vladislav V. Pavlov, Yury S. Semenov, Siarhei M. Bukhalovich, Fedor M. Tsybrov, Andrey O. Bogorodskiy, Diana F. Bagaeva, Olga V. Moiseeva, Anastasiia D. Vlasova, Anatolii E. Mikhailov, Yayu Wang, Andrey V. Rogachev, Semen V. Nesterov, Valentin I. Borshchevskiy, Chunlei Cang, Piotr D. Bregestovski, Valentin I. Gordeliy, Nikolay S. Ilyinsky

J Gen Physiol (2026) 158 (4): e202413745.

https://doi.org/10.1085/jgp.202413745

Published: 18 June 2026

View article titled, Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions

Includes: Supplementary data

Journal Articles

Vesicular monoamine transporters (VMATs): From discovery to therapeutic targets

Shimon Schuldiner

J Gen Physiol (2026) 158 (4): e202614012.

https://doi.org/10.1085/jgp.202614012

Published: 08 June 2026

View article titled, Vesicular monoamine transporters (VMATs): From discovery to therapeutic targets

Includes: Supplementary data

Journal Articles

Long-term inactivation mediated by different FGF-A homologues on heterologously expressed Na_V1.2 currents

Yenisleidy Lorenzo-Ceballos, Pedro L. Martinez-Espinosa, Xiao-Ming Xia, Christopher J. Lingle

J Gen Physiol (2026) 158 (4): e202613985.

https://doi.org/10.1085/jgp.202613985

Published: 22 May 2026

View article titled, Long-term inactivation mediated by different FGF-A homologues on heterologously expressed NaV1.2 currents

Includes: Supplementary data

Journal Articles

Evolution of our understanding of the sodium channel fast inactivation: From Hodgkin and Huxley to the structural era

Yichen Liu, Cesar A. Amaya-Rodriguez, Victoria Collio, Gabriel Ibañez, Ramón Latorre, Francisco Bezanilla

J Gen Physiol (2026) 158 (4): e202613980.

https://doi.org/10.1085/jgp.202613980

Published: 07 May 2026

View article titled, Evolution of our understanding of the sodium channel fast inactivation: From Hodgkin and Huxley to the structural era

Journal Articles

Calmodulinopathy variants impair Ca_V1.3 and Ca_V2.1 regulation

John W. Hussey, Emily DeMarco, Deborah DiSilvestre, Malene Brohus, Ana-Octavia Busuioc, Emil D. Iversen, Helene H. Jensen, Mette Nyegaard, Michael T. Overgaard, Manu Ben-Johny, Ivy E. Dick

J Gen Physiol (2026) 158 (3): e202413734.

https://doi.org/10.1085/jgp.202413734

Published: 24 April 2026

View article titled, Calmodulinopathy variants impair CaV1.3 and CaV2.1 regulation

Includes: Supplementary data

Journal Articles

Distinctive mechanical response characteristics of the guinea pig apical cochlear organ of Corti and basilar membrane

George W.S. Burwood, Tianying Ren, Edward V. Porsov, Alfred L. Nuttall, Anders Fridberger

J Gen Physiol (2026) 158 (3): e202413611.

https://doi.org/10.1085/jgp.202413611

Published: 21 April 2026

View article titled, Distinctive mechanical response characteristics of the guinea pig apical cochlear organ of Corti and basilar membrane

Includes: Supplementary data

Journal Articles

Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons

Lucas J. Handlin, Clémence Gieré, Nicolas L.A. Dumaire, Lyuba Salih, Aubin Moutal, Gucan Dai

J Gen Physiol (2026) 158 (3): e202513925.

https://doi.org/10.1085/jgp.202513925

Published: 12 March 2026

View article titled, Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons

Includes: Supplementary data

Journal Articles

Opening of rod photoreceptor CNG channels by photodynamically generated singlet oxygen

Gaogao He, Xiaoxi Li, Yanlin Huang, Conghan Wang, Minjie Tan, Qinglian Liu, Lei Zhou

J Gen Physiol (2026) 158 (3): e202513819.

https://doi.org/10.1085/jgp.202513819

Published: 05 March 2026

View article titled, Opening of rod photoreceptor CNG channels by photodynamically generated singlet oxygen

Journal Articles

Post-translational modifications of cardiac myosin-binding protein-C: Mechanisms behind fine-tuning the sarcomere

Angela C. Greenman, Willem de Lange, J. Carter Ralphe

J Gen Physiol (2026) 158 (3): e202513889.

https://doi.org/10.1085/jgp.202513889

Published: 03 March 2026

View article titled, Post-translational modifications of cardiac myosin-binding protein-C: Mechanisms behind fine-tuning the sarcomere

Journal Articles

Structure-function analysis of the lithium-ion selectivity of the voltage-gated sodium channel

Yuki K. Maeda, Kentaro Kojima, Tomoe Y. Nakamura, Toru Nakatsu, Katsumasa Irie

J Gen Physiol (2026) 158 (3): e202513855.

https://doi.org/10.1085/jgp.202513855

Published: 19 February 2026

View article titled, Structure-function analysis of the lithium-ion selectivity of the voltage-gated sodium channel

Includes: Supplementary data

Journal Articles

Molecular dynamics analyses of CLDN15 pore size and charge selectivity

Sarah McGuinness, Pan Li, Ye Li, Shadi Fuladi, Sukanya Konar, Samaneh Sajjadi, Mohammed Sidahmed, Yueying Li, Le Shen, Fatemeh Khalili-Araghi, Christopher R. Weber

J Gen Physiol (2026) 158 (2): e202513824.

https://doi.org/10.1085/jgp.202513824

Published: 12 February 2026

View article titled, Molecular dynamics analyses of CLDN15 pore size and charge selectivity

Journal Articles

Prepulse facilitation of the honeybee Ca_V4 channel is produced by a shift in channel activation and requires an intact inactivation sequence

Thierry Cens, Matthieu Rousset, Claudine Menard, Mohamed Chahine, Claude Collet, Jean-Christophe Sandoz, Alain Chavanieu, Sebastien Estaran, Jean-Baptiste Thibaud, Patrick Bois, Pierre Charnet

J Gen Physiol (2026) 158 (2): e202413712.

https://doi.org/10.1085/jgp.202413712

Published: 10 February 2026

View article titled, Prepulse facilitation of the honeybee CaV4 channel is produced by a shift in channel activation and requires an intact inactivation sequence

Journal Articles

The relationship between apparent potentiation and the magnitude of the control response

Joe Henry Steinbach, Gustav Akk

J Gen Physiol (2026) 158 (2): e202513894.

https://doi.org/10.1085/jgp.202513894

Published: 27 January 2026

View article titled, The relationship between apparent potentiation and the magnitude of the control response

Journal Articles

A critical residue mediates proper assembly and gating of GIRK2 channels

Ha Nguyen, Jonathan Mount, Keino Hutchinson, Yihan Zhao, Yulin Zhao, Ian W. Glaaser, Peng Yuan, Avner Schlessinger, Paul A. Slesinger

J Gen Physiol (2025) 158 (1): e202513817.

https://doi.org/10.1085/jgp.202513817

Published: 19 December 2025

View article titled, A critical residue mediates proper assembly and gating of GIRK2 channels

Includes: Supplementary data

Journal Articles

Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2

Diego Lopez-Mateos, Kush Narang, Vladimir Yarov-Yarovoy

J Gen Physiol (2025) 158 (2): e202413705.

https://doi.org/10.1085/jgp.202413705

Published: 18 December 2025

View article titled, Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2

Includes: Supplementary data

Journal Articles

Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?

Eduardo Rios

J Gen Physiol (2025) 158 (1): e202513877.

https://doi.org/10.1085/jgp.202513877

Published: 17 December 2025

View article titled, Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?

Journal Articles

On the mechanism of K⁺ transport through the inter-subunit tunnel of KdpFABC

Hridya Valia Madapally, Adel Hussein, Martin Wazar Eriksen, Bjørn Panyella Pedersen, David L. Stokes, Himanshu Khandelia

J Gen Physiol (2025) 158 (1): e202513794.

https://doi.org/10.1085/jgp.202513794

Published: 12 December 2025

View article titled, On the mechanism of K+ transport through the inter-subunit tunnel of KdpFABC

Includes: Supplementary data

Journal Articles

Towards a unified gating scheme for the CNBD ion channel family

Jenna L. Lin, Baron Chanda

J Gen Physiol (2025) 158 (1): e202513849.

https://doi.org/10.1085/jgp.202513849

Published: 11 December 2025

View article titled, Towards a unified gating scheme for the CNBD ion channel family

Includes: Supplementary data

Journal Articles

Novel binding mode for negative allosteric NMDA receptor modulators

James S. Lotti, Jed T. Syrenne, Avery J. Benton, Ahmad Al-Mousawi, Lauren E. Cornelison, Christopher J. Trolinder, Feng Yi, Zhucheng Zhang, Cindee K. Yates-Hansen, Levi J. McClelland, James Bosco, Andrew R. Rau, Rasmus P. Clausen, Kasper B. Hansen

J Gen Physiol (2025) 158 (1): e202513872.

https://doi.org/10.1085/jgp.202513872

Published: 03 December 2025

View article titled, Novel binding mode for negative allosteric NMDA receptor modulators

Includes: Supplementary data

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Regulation of olfactory chloride and cyclic nucleotide–gated channels by cholesterol

Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions

Vesicular monoamine transporters (VMATs): From discovery to therapeutic targets

Long-term inactivation mediated by different FGF-A homologues on heterologously expressed Na_V1.2 currents

Evolution of our understanding of the sodium channel fast inactivation: From Hodgkin and Huxley to the structural era

Calmodulinopathy variants impair Ca_V1.3 and Ca_V2.1 regulation

Distinctive mechanical response characteristics of the guinea pig apical cochlear organ of Corti and basilar membrane

Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons

Opening of rod photoreceptor CNG channels by photodynamically generated singlet oxygen

Post-translational modifications of cardiac myosin-binding protein-C: Mechanisms behind fine-tuning the sarcomere

Structure-function analysis of the lithium-ion selectivity of the voltage-gated sodium channel

Molecular dynamics analyses of CLDN15 pore size and charge selectivity

Prepulse facilitation of the honeybee Ca_V4 channel is produced by a shift in channel activation and requires an intact inactivation sequence

The relationship between apparent potentiation and the magnitude of the control response

A critical residue mediates proper assembly and gating of GIRK2 channels

Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2

Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?

On the mechanism of K⁺ transport through the inter-subunit tunnel of KdpFABC

Towards a unified gating scheme for the CNBD ion channel family

Novel binding mode for negative allosteric NMDA receptor modulators

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