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Journal Articles

β2 and β3a regulatory subunits can coassemble in the same BK channels

Yu Zhou, Vivian Gonzalez-Perez, Xiao-Ming Xia, Gopal S. Kallure, Sandipan Chowdhury, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513890.
https://doi.org/10.1085/jgp.202513890
Published: 25 November 2025
View article titled, β2 and β3a regulatory subunits can coassemble in the same BK channels
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Journal Articles

Optical control of PI(4,5)P2 sensitivity of ion channels by manipulation of single lysine residue

Junxian Zhou, Rizki Tsari Andriani, Natsuki Mizutani, Kohei Yamamoto, Daisuke Yoshioka, Akira Kawanabe, Takafumi Kawai, Yoshifumi Okochi, Yasushi Okamura
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513811.
https://doi.org/10.1085/jgp.202513811
Published: 18 November 2025
View article titled, Optical control of PI(4,5)P2 sensitivity of ion channels by manipulation of single lysine residue
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Includes: Supplementary data
Journal Articles

Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit

Daniela De Giorgis, Guido Mellado, Jose Antonio Garate, Alan Neely
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202413739.
https://doi.org/10.1085/jgp.202413739
Published: 05 November 2025
View article titled, Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit
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Includes: Supplementary data
Journal Articles

Investigating the role of the I–II linker in Nav1.5 channel function

Emily Wagner, Martina Marras, Shashi Kumar, Jacob Kelley, Kiersten Ruff, Jonathan Silva
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (6): e202413692.
https://doi.org/10.1085/jgp.202413692
Published: 04 September 2025
View article titled, Investigating the role of the I–II linker in Nav1.5 channel function
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Includes: Supplementary data
Journal Articles

GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle

Bin Sun, Alec Loftus, Brandon Beh Goh Beh, Aalaythia Hepburn, Jonathan A. Kirk, Peter M. Kekenes-Huskey
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (5): e202413737.
https://doi.org/10.1085/jgp.202413737
Published: 26 August 2025
View article titled, GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle
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Includes: Supplementary data
Journal Articles

Charybdotoxin binding to Shaker K+ channels is temperature sensitive in high external K+ but not in high external Na+

Nieves Navarro-Quezada, Francisca Salas-Sepulveda, Horacio Poblete, David Naranjo
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (5): e202413590.
https://doi.org/10.1085/jgp.202413590
Published: 07 August 2025
View article titled, Charybdotoxin binding to Shaker K+ channels is temperature sensitive in high external K+ but not in high external Na+
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Includes: Supplementary data
Journal Articles

GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains

Rebeca Martínez-Lázaro, Teresa Minguez-Viñas, Andrea Reyes-Carrión, Ricardo Gómez, Diego Alvarez de la Rosa, David Bartolomé-Martín, Teresa Giraldez
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (5): e202513799.
https://doi.org/10.1085/jgp.202513799
Published: 05 August 2025
View article titled, GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains
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Includes: Supplementary data
Journal Articles

Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation

Martin C. Heiss, Monica L. Fernández-Quintero, Marta Campiglio, Yousra El Ghaleb, Simone Pelizzari, Johannes R. Loeffler, Klaus R. Liedl, Petronel Tuluc, Bernhard E. Flucher
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (5): e202513769.
https://doi.org/10.1085/jgp.202513769
Published: 04 August 2025
View article titled, Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation
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Includes: Supplementary data
Journal Articles

Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affect β-cardiac myosin activity

Matvey Pilagov, Sonette Steczina, Ateeqa Naim, Michael Regnier, Michael A. Geeves, Neil M. Kad
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (5): e202413628.
https://doi.org/10.1085/jgp.202413628
Published: 07 July 2025
View article titled, Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affect β-cardiac myosin activity
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Includes: Supplementary data
Journal Articles

Using metaphorical considerations to benefit research on the sodium channel fast inactivation mechanism

In Special Collection:
JGP Highlights Collection 2025
Peter Hull, Angelika Lampert
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (4): e202413683.
https://doi.org/10.1085/jgp.202413683
Published: 03 June 2025
View article titled, Using metaphorical considerations to benefit research on the sodium channel fast inactivation mechanism
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Journal Articles

Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini

Yu Zhou, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (4): e202513790.
https://doi.org/10.1085/jgp.202513790
Published: 30 May 2025
View article titled, Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini
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Includes: Supplementary data
Journal Articles

Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes

Kerry S. McDonald, Theodore J. Kalogeris, Adam B. Veteto, Daniel J. Davis, Laurin M. Hanft
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (3): e202413678.
https://doi.org/10.1085/jgp.202413678
Published: 24 March 2025
View article titled, Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes
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Journal Articles

Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels

Benjamin T. Simonson, Zhaoyang Jiang, Joseph F. Ryan, Timothy Jegla
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413740.
https://doi.org/10.1085/jgp.202413740
Published: 18 March 2025
View article titled, Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels
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Includes: Supplementary data
Journal Articles

Marfan syndrome cardiomyocytes show excess of titin isoform N2BA and extended sarcomeric M-band

Dalma Kellermayer, Cristina M. Șulea, Hedvig Tordai, Kálmán Benke, Miklós Pólos, Bence Ágg, Roland Stengl, Máté Csonka, Tamás Radovits, Béla Merkely, Zoltán Szabolcs, Miklós Kellermayer, Balázs Kiss
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (3): e202413690.
https://doi.org/10.1085/jgp.202413690
Published: 10 March 2025
View article titled, Marfan syndrome cardiomyocytes show excess of titin isoform N2BA and extended sarcomeric M-band
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Includes: Supplementary data
Journal Articles

Novel Ca2+ wave mechanisms in cardiac myocytes revealed by multiscale Ca2+ release model

Morris Vysma, James S. Welsh, Derek R. Laver
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413543.
https://doi.org/10.1085/jgp.202413543
Published: 06 March 2025
View article titled, Novel Ca2+ wave mechanisms in cardiac myocytes revealed by multiscale Ca2+ release model
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Includes: Supplementary data
Journal Articles

The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses

In Special Collection:
Neuroscience Collection 2025
Wallace B. Thoreson, Thomas M. Bartol, Nicholas H. Conoan, Jeffrey S. Diamond
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413746.
https://doi.org/10.1085/jgp.202413746
Published: 28 February 2025
View article titled, The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses
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Journal Articles

In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel

Alp Tegin Şahin, Ulrich Zachariae
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202313506.
https://doi.org/10.1085/jgp.202313506
Published: 21 February 2025
View article titled, In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel
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Includes: Supplementary data
Journal Articles

Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy

John H. Lewis, Yufeng Zhou, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413709.
https://doi.org/10.1085/jgp.202413709
Published: 20 February 2025
View article titled, Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy
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Includes: Supplementary data
Journal Articles

Mechanisms underlying the distinct K+ dependencies of periodic paralysis

Brent D. Foy, Chris Dupont, Phillip V. Walker, II, Kirsten Denman, Kathrin L. Engisch, Mark M. Rich
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413610.
https://doi.org/10.1085/jgp.202413610
Published: 04 February 2025
View article titled, Mechanisms underlying the distinct K+ dependencies of periodic paralysis
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Includes: Supplementary data
Journal Articles

Inactivation of CaV1 and CaV2 channels

Worawan B. Limpitikul, Ivy E. Dick
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (2): e202313531.
https://doi.org/10.1085/jgp.202313531
Published: 30 January 2025
View article titled, Inactivation of CaV1 and CaV2 channels
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