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Journal Articles

The relationship between apparent potentiation and the magnitude of the control response

Joe Henry Steinbach, Gustav Akk
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (2): e202513894.
https://doi.org/10.1085/jgp.202513894
Published: 27 January 2026
View article titled, The relationship between apparent potentiation and the magnitude of the control response
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Journal Articles

A critical residue mediates proper assembly and gating of GIRK2 channels

Ha Nguyen, Jonathan Mount, Keino Hutchinson, Yihan Zhao, Yulin Zhao, Ian W. Glaaser, Peng Yuan, Avner Schlessinger, Paul A. Slesinger
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513817.
https://doi.org/10.1085/jgp.202513817
Published: 19 December 2025
View article titled, A critical residue mediates proper assembly and gating of GIRK2 channels
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Includes: Supplementary data
Journal Articles

Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2

Diego Lopez-Mateos, Kush Narang, Vladimir Yarov-Yarovoy
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels 2026
J Gen Physiol (2025) 158 (2): e202413705.
https://doi.org/10.1085/jgp.202413705
Published: 18 December 2025
View article titled, Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2
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Includes: Supplementary data
Journal Articles

Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?

Eduardo Rios
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513877.
https://doi.org/10.1085/jgp.202513877
Published: 17 December 2025
View article titled, Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?
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Journal Articles

On the mechanism of K+ transport through the inter-subunit tunnel of KdpFABC

Hridya Valia Madapally, Adel Hussein, Martin Wazar Eriksen, Bjørn Panyella Pedersen, David L. Stokes, Himanshu Khandelia
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513794.
https://doi.org/10.1085/jgp.202513794
Published: 12 December 2025
View article titled, On the mechanism of K+ transport through the inter-subunit tunnel of KdpFABC
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Includes: Supplementary data
Journal Articles

Towards a unified gating scheme for the CNBD ion channel family

Jenna L. Lin, Baron Chanda
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513849.
https://doi.org/10.1085/jgp.202513849
Published: 11 December 2025
View article titled, Towards a unified gating scheme for the CNBD ion channel family
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Includes: Supplementary data
Journal Articles

Novel binding mode for negative allosteric NMDA receptor modulators

James S. Lotti, Jed T. Syrenne, Avery J. Benton, Ahmad Al-Mousawi, Lauren E. Cornelison, Christopher J. Trolinder, Feng Yi, Zhucheng Zhang, Cindee K. Yates-Hansen, Levi J. McClelland, James Bosco, Andrew R. Rau, Rasmus P. Clausen, Kasper B. Hansen
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513872.
https://doi.org/10.1085/jgp.202513872
Published: 03 December 2025
View article titled, Novel binding mode for negative allosteric NMDA receptor modulators
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Includes: Supplementary data
Journal Articles

Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel

Akshay Sharma, Christopher Marra, Nomon Mohammad, Vasilisa Iatckova, Lillian Lawrence, Mitchell Goldfarb
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513835.
https://doi.org/10.1085/jgp.202513835
Published: 02 December 2025
View article titled, Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel
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Includes: Supplementary data
Journal Articles

β2 and β3a regulatory subunits can coassemble in the same BK channels

Yu Zhou, Vivian Gonzalez-Perez, Xiao-Ming Xia, Gopal S. Kallure, Sandipan Chowdhury, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513890.
https://doi.org/10.1085/jgp.202513890
Published: 25 November 2025
View article titled, β2 and β3a regulatory subunits can coassemble in the same BK channels
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Journal Articles

Optical control of PI(4,5)P2 sensitivity of ion channels by manipulation of single lysine residue

Junxian Zhou, Rizki Tsari Andriani, Natsuki Mizutani, Kohei Yamamoto, Daisuke Yoshioka, Akira Kawanabe, Takafumi Kawai, Yoshifumi Okochi, Yasushi Okamura
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513811.
https://doi.org/10.1085/jgp.202513811
Published: 18 November 2025
View article titled, Optical control of PI(4,5)P2 sensitivity of ion channels by manipulation of single lysine residue
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Includes: Supplementary data
Journal Articles

Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit

Daniela De Giorgis, Guido Mellado, Jose Antonio Garate, Alan Neely
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202413739.
https://doi.org/10.1085/jgp.202413739
Published: 05 November 2025
View article titled, Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit
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Includes: Supplementary data
Journal Articles

Investigating the role of the I–II linker in Nav1.5 channel function

Emily Wagner, Martina Marras, Shashi Kumar, Jacob Kelley, Kiersten Ruff, Jonathan Silva
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (6): e202413692.
https://doi.org/10.1085/jgp.202413692
Published: 04 September 2025
View article titled, Investigating the role of the I–II linker in Nav1.5 channel function
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Includes: Supplementary data
Journal Articles

GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle

Bin Sun, Alec Loftus, Brandon Beh Goh Beh, Aalaythia Hepburn, Jonathan A. Kirk, Peter M. Kekenes-Huskey
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (5): e202413737.
https://doi.org/10.1085/jgp.202413737
Published: 26 August 2025
View article titled, GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle
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Includes: Supplementary data
Journal Articles

Charybdotoxin binding to Shaker K+ channels is temperature sensitive in high external K+ but not in high external Na+

Nieves Navarro-Quezada, Francisca Salas-Sepulveda, Horacio Poblete, David Naranjo
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (5): e202413590.
https://doi.org/10.1085/jgp.202413590
Published: 07 August 2025
View article titled, Charybdotoxin binding to Shaker K+ channels is temperature sensitive in high external K+ but not in high external Na+
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Includes: Supplementary data
Journal Articles

GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains

Rebeca Martínez-Lázaro, Teresa Minguez-Viñas, Andrea Reyes-Carrión, Ricardo Gómez, Diego Alvarez de la Rosa, David Bartolomé-Martín, Teresa Giraldez
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (5): e202513799.
https://doi.org/10.1085/jgp.202513799
Published: 05 August 2025
View article titled, GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains
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Includes: Supplementary data
Journal Articles

Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation

Martin C. Heiss, Monica L. Fernández-Quintero, Marta Campiglio, Yousra El Ghaleb, Simone Pelizzari, Johannes R. Loeffler, Klaus R. Liedl, Petronel Tuluc, Bernhard E. Flucher
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (5): e202513769.
https://doi.org/10.1085/jgp.202513769
Published: 04 August 2025
View article titled, Voltage-sensor gating charge interactions bimodally regulate voltage dependence and kinetics of calcium channel activation
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Includes: Supplementary data
Journal Articles

Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affect β-cardiac myosin activity

Matvey Pilagov, Sonette Steczina, Ateeqa Naim, Michael Regnier, Michael A. Geeves, Neil M. Kad
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (5): e202413628.
https://doi.org/10.1085/jgp.202413628
Published: 07 July 2025
View article titled, Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affect β-cardiac myosin activity
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Includes: Supplementary data
Journal Articles

Using metaphorical considerations to benefit research on the sodium channel fast inactivation mechanism

In Special Collection:
JGP Highlights Collection 2025
Peter Hull, Angelika Lampert
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (4): e202413683.
https://doi.org/10.1085/jgp.202413683
Published: 03 June 2025
View article titled, Using metaphorical considerations to benefit research on the sodium channel fast inactivation mechanism
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Journal Articles

Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini

Yu Zhou, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (4): e202513790.
https://doi.org/10.1085/jgp.202513790
Published: 30 May 2025
View article titled, Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini
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Includes: Supplementary data
Journal Articles

Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes

Kerry S. McDonald, Theodore J. Kalogeris, Adam B. Veteto, Daniel J. Davis, Laurin M. Hanft
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (3): e202413678.
https://doi.org/10.1085/jgp.202413678
Published: 24 March 2025
View article titled, Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes
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