Cellular Physiology
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Journal Articles

A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions

Ryan J. Farrell, S. Thomas Hennigan, Kirsten G. Bredvik, Michael B. Hoppa, Timothy A. Brown, Timothy A. Ryan
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202413564.
https://doi.org/10.1085/jgp.202413564
Published: 19 August 2026
View article titled, A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions
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Journal Articles

Allosteric interactions between RyR channels justify intracellular Ca2+ release of skeletal muscle in quantitative detail

Eduardo Rios, Gonzalo Pizarro
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202613968.
https://doi.org/10.1085/jgp.202613968
Published: 21 July 2026
View article titled, Allosteric interactions between RyR channels justify intracellular Ca2+ release of skeletal muscle in quantitative detail
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Journal Articles

Kinetic reconstruction of graded membrane excitability in Paramecium

Takashi Tominaga, Yoko Tominaga
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202613977.
https://doi.org/10.1085/jgp.202613977
Published: 07 July 2026
View article titled, Kinetic reconstruction of graded membrane excitability in Paramecium
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Journal Articles

On the mechanism of hypomagnesemia with treatment-resistant seizures caused by variants of the Na+,K+-ATPase α1 subunit (ATP1A1)

Nicolas Colmano, Daniel Self, Hang N. Nielsen, Rikke Holm, Chai C. Gopalasingam, Ryota Fujimura, Kazuhiro Abe, Bente Vilsen, Sho T. Yano, Pablo Artigas
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (5): e202513959.
https://doi.org/10.1085/jgp.202513959
Published: 30 June 2026
View article titled, On the mechanism of hypomagnesemia with treatment-resistant seizures caused by variants of the Na+,K+-ATPase α1 subunit (ATP1A1)
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Includes: Supplementary data
Journal Articles

Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions

Sofia F. Nazarova, Vadim A. Alekhin, Vladislav V. Pavlov, Yury S. Semenov, Siarhei M. Bukhalovich, Fedor M. Tsybrov, Andrey O. Bogorodskiy, Diana F. Bagaeva, Olga V. Moiseeva, Anastasiia D. Vlasova, Anatolii E. Mikhailov, Yayu Wang, Andrey V. Rogachev, Semen V. Nesterov, Valentin I. Borshchevskiy, Chunlei Cang, Piotr D. Bregestovski, Valentin I. Gordeliy, Nikolay S. Ilyinsky
Journal: Journal of General Physiology
Series: Molecular evolution in the membrane
J Gen Physiol (2026) 158 (4): e202413745.
https://doi.org/10.1085/jgp.202413745
Published: 18 June 2026
View article titled, Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions
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Includes: Supplementary data
Journal Articles

Vesicular monoamine transporters (VMATs): From discovery to therapeutic targets

Shimon Schuldiner
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (4): e202614012.
https://doi.org/10.1085/jgp.202614012
Published: 08 June 2026
View article titled, Vesicular monoamine transporters (VMATs): From discovery to therapeutic targets
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Includes: Supplementary data
Journal Articles

A kinetic trap mechanism underlies hHv1 inhibition by NZ-58

Adam Feher, Geraldo Jorge Domingos, Martina Piga, Tihomir Tomašič, Nace Zidar, Zoltan Varga
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (4): e202513945.
https://doi.org/10.1085/jgp.202513945
Published: 28 May 2026
View article titled, A kinetic trap mechanism underlies hHv1 inhibition by NZ-58
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Includes: Supplementary data
Journal Articles

Long-term inactivation mediated by different FGF-A homologues on heterologously expressed NaV1.2 currents

In Special Collection:
Voltage-Gated Na Channels 2026
Yenisleidy Lorenzo-Ceballos, Pedro L. Martinez-Espinosa, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels 2026
J Gen Physiol (2026) 158 (4): e202613985.
https://doi.org/10.1085/jgp.202613985
Published: 22 May 2026
View article titled, Long-term inactivation mediated by different FGF-A homologues on heterologously expressed NaV1.2 currents
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Includes: Supplementary data
Journal Articles

Structural determinants at KCNE4 position 145 govern Kv1.3 channel function

Magalí Colomer-Molera, Daniel Sastre, Antonio Felipe
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (4): e202513936.
https://doi.org/10.1085/jgp.202513936
Published: 20 May 2026
View article titled, Structural determinants at KCNE4 position 145 govern Kv1.3 channel function
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Includes: Supplementary data
Journal Articles

Calmodulinopathy variants impair CaV1.3 and CaV2.1 regulation

John W. Hussey, Emily DeMarco, Deborah DiSilvestre, Malene Brohus, Ana-Octavia Busuioc, Emil D. Iversen, Helene H. Jensen, Mette Nyegaard, Michael T. Overgaard, Manu Ben-Johny, Ivy E. Dick
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202413734.
https://doi.org/10.1085/jgp.202413734
Published: 24 April 2026
View article titled, Calmodulinopathy variants impair CaV1.3 and CaV2.1 regulation
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Includes: Supplementary data
Journal Articles

Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles

Manuel F. Muñoz, Collin Matsumoto, Paula Rhana, Declan Manning, Geoanna M. Bautista, Daniel M. Collier, L. Fernando Santana
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (3): e202513874.
https://doi.org/10.1085/jgp.202513874
Published: 31 March 2026
View article titled, Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles
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Journal Articles

Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons

Lucas J. Handlin, Clémence Gieré, Nicolas L.A. Dumaire, Lyuba Salih, Aubin Moutal, Gucan Dai
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202513925.
https://doi.org/10.1085/jgp.202513925
Published: 12 March 2026
View article titled, Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons
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Includes: Supplementary data
Journal Articles

Titin’s P-zone domains A164–167 are essential for thick filament structural arrangement

Catherine Hoover Browne, Seong-won Han, Gerrie P. Farman, John E. Smith, Justin Kolb, Jochen Gohlke, Paul R. Langlais, Paola Tonino, Mei Methawasin, Robbert van der Pijl, Henk Granzier
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202513891.
https://doi.org/10.1085/jgp.202513891
Published: 12 March 2026
View article titled, Titin’s P-zone domains A164–167 are essential for thick filament structural arrangement
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Includes: Supplementary data
Journal Articles

Prepulse facilitation of the honeybee CaV4 channel is produced by a shift in channel activation and requires an intact inactivation sequence

Thierry Cens, Matthieu Rousset, Claudine Menard, Mohamed Chahine, Claude Collet, Jean-Christophe Sandoz, Alain Chavanieu, Sebastien Estaran, Jean-Baptiste Thibaud, Patrick Bois, Pierre Charnet
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (2): e202413712.
https://doi.org/10.1085/jgp.202413712
Published: 10 February 2026
View article titled, Prepulse facilitation of the honeybee CaV4 channel is produced by a shift in channel activation and requires an intact inactivation sequence
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Journal Articles

AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic bradycardia

Luca M.G. Palloni, Nicole Sarno, Caterina Azzoni, Nicol Furia, Matteo E. Mangoni, Alessandro Porro, Teresa Neeman, Andrea Saponaro, Gerhard Thiel, Anna Moroni, Dario DiFrancesco
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (2): e202513873.
https://doi.org/10.1085/jgp.202513873
Published: 06 February 2026
View article titled, AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic bradycardia
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Includes: Supplementary data
Journal Articles

Coincidence detection supported by electrical synapses is shaped by the D-type K+ current

Antonella Dapino, Sebastián Curti
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (2): e202513883.
https://doi.org/10.1085/jgp.202513883
Published: 30 January 2026
View article titled, Coincidence detection supported by electrical synapses is shaped by the D-type K+ current
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Includes: Supplementary data
Journal Articles

Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel

Akshay Sharma, Christopher Marra, Nomon Mohammad, Vasilisa Iatckova, Lillian Lawrence, Mitchell Goldfarb
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513835.
https://doi.org/10.1085/jgp.202513835
Published: 02 December 2025
View article titled, Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel
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Includes: Supplementary data
Journal Articles

β2 and β3a regulatory subunits can coassemble in the same BK channels

Yu Zhou, Vivian Gonzalez-Perez, Xiao-Ming Xia, Gopal S. Kallure, Sandipan Chowdhury, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513890.
https://doi.org/10.1085/jgp.202513890
Published: 25 November 2025
View article titled, β2 and β3a regulatory subunits can coassemble in the same BK channels
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Journal Articles

Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry

Francisco Jaque-Fernandez, Léa Demesmay, Romane Idoux, Christine Berthier, Vincent Jacquemond, Bruno Allard
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513800.
https://doi.org/10.1085/jgp.202513800
Published: 11 November 2025
View article titled, Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry
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Journal Articles

Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture

Leander A. Vonk, Osman Esen, Daan Hoomoedt, Rajvi M.N. Balesar, Coen A.C. Ottenheijm, Tyler J. Kirby
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513761.
https://doi.org/10.1085/jgp.202513761
Published: 03 November 2025
View article titled, Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture
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Includes: Supplementary data

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