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A kinetic trap mechanism underlies hHv1 inhibition by NZ-58

Adam Feher, Geraldo Jorge Domingos, Martina Piga, Tihomir Tomašič, Nace Zidar, Zoltan Varga

J Gen Physiol (2026) 158 (4): e202513945.

https://doi.org/10.1085/jgp.202513945

Published: 28 May 2026

View article titled, A kinetic trap mechanism underlies hHv1 inhibition by NZ-58

Includes: Supplementary data

Journal Articles

Long-term inactivation mediated by different FGF-A homologues on heterologously expressed Na_V1.2 currents

Yenisleidy Lorenzo-Ceballos, Pedro L. Martinez-Espinosa, Xiao-Ming Xia, Christopher J. Lingle

J Gen Physiol (2026) 158 (4): e202613985.

https://doi.org/10.1085/jgp.202613985

Published: 22 May 2026

View article titled, Long-term inactivation mediated by different FGF-A homologues on heterologously expressed NaV1.2 currents

Includes: Supplementary data

Journal Articles

Structural determinants at KCNE4 position 145 govern Kv1.3 channel function

Magalí Colomer-Molera, Daniel Sastre, Antonio Felipe

J Gen Physiol (2026) 158 (4): e202513936.

https://doi.org/10.1085/jgp.202513936

Published: 20 May 2026

View article titled, Structural determinants at KCNE4 position 145 govern Kv1.3 channel function

Includes: Supplementary data

Journal Articles

Calmodulinopathy variants impair Ca_V1.3 and Ca_V2.1 regulation

John W. Hussey, Emily DeMarco, Deborah DiSilvestre, Malene Brohus, Ana-Octavia Busuioc, Emil D. Iversen, Helene H. Jensen, Mette Nyegaard, Michael T. Overgaard, Manu Ben-Johny, Ivy E. Dick

J Gen Physiol (2026) 158 (3): e202413734.

https://doi.org/10.1085/jgp.202413734

Published: 24 April 2026

View article titled, Calmodulinopathy variants impair CaV1.3 and CaV2.1 regulation

Includes: Supplementary data

Journal Articles

Beat-locked ATP microdomains in the sinoatrial node map a Ca²⁺-timed energetic hierarchy and regional pacemaker roles

Manuel F. Muñoz, Collin Matsumoto, Paula Rhana, Declan Manning, Geoanna M. Bautista, Daniel M. Collier, L. Fernando Santana

J Gen Physiol (2026) 158 (3): e202513874.

https://doi.org/10.1085/jgp.202513874

Published: 31 March 2026

View article titled, Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles

Journal Articles

Titin’s P-zone domains A164–167 are essential for thick filament structural arrangement

Catherine Hoover Browne, Seong-won Han, Gerrie P. Farman, John E. Smith, Justin Kolb, Jochen Gohlke, Paul R. Langlais, Paola Tonino, Mei Methawasin, Robbert van der Pijl, Henk Granzier

J Gen Physiol (2026) 158 (3): e202513891.

https://doi.org/10.1085/jgp.202513891

Published: 12 March 2026

View article titled, Titin’s P-zone domains A164–167 are essential for thick filament structural arrangement

Includes: Supplementary data

Journal Articles

Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons

Lucas J. Handlin, Clémence Gieré, Nicolas L.A. Dumaire, Lyuba Salih, Aubin Moutal, Gucan Dai

J Gen Physiol (2026) 158 (3): e202513925.

https://doi.org/10.1085/jgp.202513925

Published: 12 March 2026

View article titled, Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons

Includes: Supplementary data

Journal Articles

Prepulse facilitation of the honeybee Ca_V4 channel is produced by a shift in channel activation and requires an intact inactivation sequence

Thierry Cens, Matthieu Rousset, Claudine Menard, Mohamed Chahine, Claude Collet, Jean-Christophe Sandoz, Alain Chavanieu, Sebastien Estaran, Jean-Baptiste Thibaud, Patrick Bois, Pierre Charnet

J Gen Physiol (2026) 158 (2): e202413712.

https://doi.org/10.1085/jgp.202413712

Published: 10 February 2026

View article titled, Prepulse facilitation of the honeybee CaV4 channel is produced by a shift in channel activation and requires an intact inactivation sequence

Journal Articles

AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic bradycardia

Luca M.G. Palloni, Nicole Sarno, Caterina Azzoni, Nicol Furia, Matteo E. Mangoni, Alessandro Porro, Teresa Neeman, Andrea Saponaro, Gerhard Thiel, Anna Moroni, Dario DiFrancesco

J Gen Physiol (2026) 158 (2): e202513873.

https://doi.org/10.1085/jgp.202513873

Published: 06 February 2026

View article titled, AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic bradycardia

Includes: Supplementary data

Journal Articles

Coincidence detection supported by electrical synapses is shaped by the D-type K⁺ current

Antonella Dapino, Sebastián Curti

J Gen Physiol (2026) 158 (2): e202513883.

https://doi.org/10.1085/jgp.202513883

Published: 30 January 2026

View article titled, Coincidence detection supported by electrical synapses is shaped by the D-type K+ current

Includes: Supplementary data

Journal Articles

Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel

Akshay Sharma, Christopher Marra, Nomon Mohammad, Vasilisa Iatckova, Lillian Lawrence, Mitchell Goldfarb

J Gen Physiol (2025) 158 (1): e202513835.

https://doi.org/10.1085/jgp.202513835

Published: 02 December 2025

View article titled, Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel

Includes: Supplementary data

Journal Articles

β2 and β3a regulatory subunits can coassemble in the same BK channels

Yu Zhou, Vivian Gonzalez-Perez, Xiao-Ming Xia, Gopal S. Kallure, Sandipan Chowdhury, Christopher J. Lingle

J Gen Physiol (2025) 158 (1): e202513890.

https://doi.org/10.1085/jgp.202513890

Published: 25 November 2025

View article titled, β2 and β3a regulatory subunits can coassemble in the same BK channels

Journal Articles

Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry

Francisco Jaque-Fernandez, Léa Demesmay, Romane Idoux, Christine Berthier, Vincent Jacquemond, Bruno Allard

J Gen Physiol (2025) 158 (1): e202513800.

https://doi.org/10.1085/jgp.202513800

Published: 11 November 2025

View article titled, Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry

Journal Articles

Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture

Leander A. Vonk, Osman Esen, Daan Hoomoedt, Rajvi M.N. Balesar, Coen A.C. Ottenheijm, Tyler J. Kirby

J Gen Physiol (2025) 158 (1): e202513761.

https://doi.org/10.1085/jgp.202513761

Published: 03 November 2025

View article titled, Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture

Includes: Supplementary data

Journal Articles

A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness

Sho Horie, Konan Sakuta, Keigo Tada, Haruki Tokumoto, Taketo Nishimoto, Katsunori Kitano, Masao Tachibana, Chieko Koike

J Gen Physiol (2025) 157 (6): e202413749.

https://doi.org/10.1085/jgp.202413749

Published: 16 October 2025

View article titled, A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness

Includes: Supplementary data

Journal Articles

SUMOylation and an ATS1 variant converge to disrupt PIP₂-dependent gating of Kir2.1

Aishwarya Chandrashekar, Yu Xu, Xinyi Ma, Anne K. Yauch, Elizabeth Scholl, Yuchen Yang, Kirin D. Gada, Takeharu Kawano, Meng Cui, Leigh D. Plant

J Gen Physiol (2025) 157 (6): e202513837.

https://doi.org/10.1085/jgp.202513837

Published: 14 October 2025

View article titled, SUMOylation and an ATS1 variant converge to disrupt PIP2-dependent gating of Kir2.1

Includes: Supplementary data

Journal Articles

Kinetics of aldosterone-dependent ENaC trafficking in the kidney

Gustavo Frindt, Shujie Shi, Trine Krogh-Madsen, Theresa Rohan, Sarah Christine M. Whelan, Lawrence G. Palmer

J Gen Physiol (2025) 157 (5): e202513821.

https://doi.org/10.1085/jgp.202513821

Published: 12 August 2025

View article titled, Kinetics of aldosterone-dependent ENaC trafficking in the kidney

Includes: Supplementary data

Journal Articles

GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains

Rebeca Martínez-Lázaro, Teresa Minguez-Viñas, Andrea Reyes-Carrión, Ricardo Gómez, Diego Alvarez de la Rosa, David Bartolomé-Martín, Teresa Giraldez

J Gen Physiol (2025) 157 (5): e202513799.

https://doi.org/10.1085/jgp.202513799

Published: 05 August 2025

View article titled, GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains

Includes: Supplementary data

Journal Articles

Variability in reported midpoints of (in)activation of cardiac I_Na

Michael Clerx, Paul G.A. Volders, Gary R. Mirams

J Gen Physiol (2025) 157 (5): e202413621.

https://doi.org/10.1085/jgp.202413621

Published: 16 July 2025

View article titled, Variability in reported midpoints of (in)activation of cardiac INa

Includes: Supplementary data

Journal Articles

Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44

David Gong, Jennifer L. Orthmann-Murphy, Deepak Kumar, Gabriel D. Dungan, Ayman W. El-Hattab, Nicoline Schiess, Yun L. Luo, Mona M. Freidin, Charles K. Abrams

J Gen Physiol (2025) 157 (4): e202413617.

https://doi.org/10.1085/jgp.202413617

Published: 10 June 2025

View article titled, Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44

Includes: Supplementary data

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A kinetic trap mechanism underlies hHv1 inhibition by NZ-58

Long-term inactivation mediated by different FGF-A homologues on heterologously expressed Na_V1.2 currents

Structural determinants at KCNE4 position 145 govern Kv1.3 channel function

Calmodulinopathy variants impair Ca_V1.3 and Ca_V2.1 regulation

Beat-locked ATP microdomains in the sinoatrial node map a Ca²⁺-timed energetic hierarchy and regional pacemaker roles

Titin’s P-zone domains A164–167 are essential for thick filament structural arrangement

Sequential membrane remodeling by cholesterol distinctly modulates HCN channels in naïve and neuropathic DRG neurons

Prepulse facilitation of the honeybee Ca_V4 channel is produced by a shift in channel activation and requires an intact inactivation sequence

AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic bradycardia

Coincidence detection supported by electrical synapses is shaped by the D-type K⁺ current

Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel

β2 and β3a regulatory subunits can coassemble in the same BK channels

Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry

Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture

A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness

SUMOylation and an ATS1 variant converge to disrupt PIP₂-dependent gating of Kir2.1

Kinetics of aldosterone-dependent ENaC trafficking in the kidney

GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains

Variability in reported midpoints of (in)activation of cardiac I_Na

Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44

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