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Journal Articles

Reduced voltage-activated Ca2+ release flux in muscle fibers from a rat model of Duchenne dystrophy

Jonathan Schreiber, Ludivine Rotard, Yves Tourneur, Aude Lafoux, Christine Berthier, Bruno Allard, Corinne Huchet, Vincent Jacquemond
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (2): e202413588.
https://doi.org/10.1085/jgp.202413588
Published: 24 December 2024
View article titled, Reduced voltage-activated Ca<sup>2+</sup> release flux in muscle fibers from a rat model of Duchenne dystrophy
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Journal Articles

Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers

Smriti Gupta, Yu-Hsin Chiu, Mohan C. Manjegowda, Bimal N. Desai, Kodi S. Ravichandran, Douglas A. Bayliss
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413676.
https://doi.org/10.1085/jgp.202413676
Published: 20 December 2024
View article titled, Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers
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Journal Articles

How does mitochondrial Ca2+ change during ischemia and reperfusion? Implications for activation of the permeability transition pore

Elizabeth Murphy, David A. Eisner
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202313520.
https://doi.org/10.1085/jgp.202313520
Published: 19 December 2024
View article titled, How does mitochondrial Ca<sup>2+</sup> change during ischemia and reperfusion? Implications for activation of the permeability transition pore
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Journal Articles

Intrinsic adaptive plasticity in mouse and human sensory neurons

Lisa A. McIlvried, John Smith Del Rosario, Melanie Y. Pullen, Andi Wangzhou, Tayler D. Sheahan, Andrew J. Shepherd, Richard A. Slivicki, John A. Lemen, Theodore J. Price, Bryan A. Copits, Robert W. Gereau, IV
Journal: Journal of General Physiology
Series: Pain Focus
J Gen Physiol (2024) 157 (1): e202313488.
https://doi.org/10.1085/jgp.202313488
Published: 17 December 2024
View article titled, Intrinsic adaptive plasticity in mouse and human sensory neurons
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Journal Articles

Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina

Olga Chernyshkova, Natalia Erofeeva, Darya Meshalkina, Anna Balykina, Stepan Gambaryan, Michael Belyakov, Michael Firsov
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (11): e202313530.
https://doi.org/10.1085/jgp.202313530
Published: 22 October 2024
View article titled, Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina
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Includes: Supplementary data
Journal Articles

Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain

Dmytro V. Vasylyev, Peng Zhao, Betsy R. Schulman, Stephen G. Waxman
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2024) 156 (11): e202413596.
https://doi.org/10.1085/jgp.202413596
Published: 08 October 2024
View article titled, Interplay of Na<sub>v</sub>1.8 and Na<sub>v</sub>1.7 channels drives neuronal hyperexcitability in neuropathic pain
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Includes: Supplementary data
Journal Articles

A pore locus in the E1 domain differentially regulates Cx26 and Cx30 hemichannel function

Helmuth A. Sanchez, Lina Kraujaliene, Vytas K. Verselis
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (11): e202313502.
https://doi.org/10.1085/jgp.202313502
Published: 20 September 2024
View article titled, A pore locus in the E1 domain differentially regulates Cx26 and Cx30 hemichannel function
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Journal Articles

An Ala/Glu difference in E1 of Cx26 and Cx30 contributes to their differential anionic permeabilities

Lina Kraujaliene, Tadas Kraujalis, Mindaugas Snipas, Vytas K. Verselis
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (11): e202413600.
https://doi.org/10.1085/jgp.202413600
Published: 20 September 2024
View article titled, An Ala/Glu difference in E1 of Cx26 and Cx30 contributes to their differential anionic permeabilities
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Includes: Supplementary data
Journal Articles

Using neural networks for image analysis in general physiology

Eduardo Rios
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (10): e202413623.
https://doi.org/10.1085/jgp.202413623
Published: 17 September 2024
View article titled, Using neural networks for image analysis in general physiology
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Journal Articles

Fluorescence labeling strategies for cell surface expression of TRPV1

Taylor M. Mott, Grace C. Wulffraat, Alex J. Eddins, Ryan A. Mehl, Eric N. Senning
Journal: Journal of General Physiology
Series: Pain Focus
J Gen Physiol (2024) 156 (10): e202313523.
https://doi.org/10.1085/jgp.202313523
Published: 20 August 2024
View article titled, Fluorescence labeling strategies for cell surface expression of TRPV1
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Includes: Supplementary data
Journal Articles

Ion channels of cold transduction and transmission

In Special Collection:
Molecular Insights into Membrane Protein Function
Cheyanne M. Lewis, Theanne N. Griffith
Journal: Journal of General Physiology
Series: Pain Focus
J Gen Physiol (2024) 156 (10): e202313529.
https://doi.org/10.1085/jgp.202313529
Published: 25 July 2024
View article titled, Ion channels of cold transduction and transmission
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Journal Articles

Epilepsy-associated Kv1.1 channel subunits regulate intrinsic cardiac pacemaking in mice

Man Si, Ahmad Darvish, Kelsey Paulhus, Praveen Kumar, Kathryn A. Hamilton, Edward Glasscock
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (9): e202413578.
https://doi.org/10.1085/jgp.202413578
Published: 22 July 2024
View article titled, Epilepsy-associated Kv1.1 channel subunits regulate intrinsic cardiac pacemaking in mice
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Journal Articles

Mathematical modeling of intracellular osmolarity and cell volume stabilization: The Donnan effect and ion transport

Zahra Aminzare, Alan R. Kay
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (8): e202413554.
https://doi.org/10.1085/jgp.202413554
Published: 12 July 2024
View article titled, Mathematical modeling of intracellular osmolarity and cell volume stabilization: The Donnan effect and ion transport
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Journal Articles

The C-terminus of Rad is required for membrane localization and L-type calcium channel regulation

Garrett Elmore, Brooke M. Ahern, Nicholas M. McVay, Kyle W. Barker, Sarisha S. Lohano, Nemat Ali, Andrea Sebastian, Douglas A. Andres, Jonathan Satin, Bryana M. Levitan
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (9): e202313518.
https://doi.org/10.1085/jgp.202313518
Published: 11 July 2024
View article titled, The C-terminus of Rad is required for membrane localization and L-type calcium channel regulation
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Includes: Supplementary data
Journal Articles

Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue

Eduardo Ríos, Montserrat Samsó, Lourdes C. Figueroa, Carlo Manno, Eshwar R. Tammineni, Lucas Rios Giordano, Sheila Riazi
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (9): e202413595.
https://doi.org/10.1085/jgp.202413595
Published: 09 July 2024
View article titled, Artificial intelligence approaches to the volumetric quantification of glycogen granules in EM images of human tissue
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Includes: Supplementary data
Journal Articles

Different fluorescent labels report distinct components of spHCN channel voltage sensor movement

Magdalena N. Wojciechowski, Chaseley E. McKenzie, Andrew Hung, Alibek Kuanyshbek, Ming S. Soh, Christopher A. Reid, Ian C. Forster
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (8): e202413559.
https://doi.org/10.1085/jgp.202413559
Published: 05 July 2024
View article titled, Different fluorescent labels report distinct components of spHCN channel voltage sensor movement
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Includes: Supplementary data
Journal Articles

Fusion pore flux controls the rise-times of quantal synaptic responses

In Special Collection:
Molecular Insights into Membrane Protein Function
Meyer B. Jackson, Chung-Wei Chiang, Jinbo Cheng
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (8): e202313484.
https://doi.org/10.1085/jgp.202313484
Published: 11 June 2024
View article titled, Fusion pore flux controls the rise-times of quantal synaptic responses
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Journal Articles

A novel, patient-derived RyR1 mutation impairs muscle function and calcium homeostasis in mice

Sofia Benucci, Alexis Ruiz, Martina Franchini, Lucia Ruggiero, Dario Zoppi, Rebecca Sitsapesan, Chris Lindsay, Pawel Pelczar, Laura Pietrangelo, Feliciano Protasi, Susan Treves, Francesco Zorzato
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (4): e202313486.
https://doi.org/10.1085/jgp.202313486
Published: 04 March 2024
View article titled, A novel, patient-derived RyR1 mutation impairs muscle function and calcium homeostasis in mice
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Includes: Supplementary data
Journal Articles

Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers

Parisa Asghari, David R.L. Scriven, Saba Shahrasebi, Hector H. Valdivia, Katherina M. Alsina, Carmen R. Valdivia, J. Alberto Navarro-Garcia, Xander H.T. Wehrens, Edwin D.W. Moore
Journal: Journal of General Physiology
Series: Excitation–Contraction Coupling
J Gen Physiol (2024) 156 (4): e202213108.
https://doi.org/10.1085/jgp.202213108
Published: 22 February 2024
View article titled, Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers
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Includes: Supplementary data
Journal Articles

Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy

Ricardo A. Galli, Tamara C. Borsboom, Charlotte Gineste, Lorenza Brocca, Maira Rossi, Darren T. Hwee, Fady I. Malik, Roberto Bottinelli, Julien Gondin, Maria-Antonietta Pellegrino, Josine M. de Winter, Coen A.C. Ottenheijm
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (4): e202313471.
https://doi.org/10.1085/jgp.202313471
Published: 20 February 2024
View article titled, <em>Tirasemtiv</em> enhances submaximal muscle tension in an <em>Acta1</em>:p.Asp286Gly mouse model of nemaline myopathy
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Includes: Supplementary data