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Journal Articles

β2 and β3a regulatory subunits can coassemble in the same BK channels

Yu Zhou, Vivian Gonzalez-Perez, Xiao-Ming Xia, Gopal S. Kallure, Sandipan Chowdhury, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513890.
https://doi.org/10.1085/jgp.202513890
Published: 25 November 2025
View article titled, β2 and β3a regulatory subunits can coassemble in the same BK channels
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Journal Articles

Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry

Francisco Jaque-Fernandez, Léa Demesmay, Romane Idoux, Christine Berthier, Vincent Jacquemond, Bruno Allard
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513800.
https://doi.org/10.1085/jgp.202513800
Published: 11 November 2025
View article titled, Mn quenching in activated zebrafish muscle fibers does not result from store-operated Ca entry
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Journal Articles

Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture

Leander A. Vonk, Osman Esen, Daan Hoomoedt, Rajvi M.N. Balesar, Coen A.C. Ottenheijm, Tyler J. Kirby
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513761.
https://doi.org/10.1085/jgp.202513761
Published: 03 November 2025
View article titled, Embedding muscle fibers in hydrogel improves viability and preserves contractile function during prolonged ex vivo culture
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Includes: Supplementary data
Journal Articles

A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness

Sho Horie, Konan Sakuta, Keigo Tada, Haruki Tokumoto, Taketo Nishimoto, Katsunori Kitano, Masao Tachibana, Chieko Koike
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (6): e202413749.
https://doi.org/10.1085/jgp.202413749
Published: 16 October 2025
View article titled, A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness
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Includes: Supplementary data
Journal Articles

SUMOylation and an ATS1 variant converge to disrupt PIP2-dependent gating of Kir2.1

Aishwarya Chandrashekar, Yu Xu, Xinyi Ma, Anne K. Yauch, Elizabeth Scholl, Yuchen Yang, Kirin D. Gada, Takeharu Kawano, Meng Cui, Leigh D. Plant
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2025) 157 (6): e202513837.
https://doi.org/10.1085/jgp.202513837
Published: 14 October 2025
View article titled, SUMOylation and an ATS1 variant converge to disrupt PIP2-dependent gating of Kir2.1
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Includes: Supplementary data
Journal Articles

Kinetics of aldosterone-dependent ENaC trafficking in the kidney

Gustavo Frindt, Shujie Shi, Trine Krogh-Madsen, Theresa Rohan, Sarah Christine M. Whelan, Lawrence G. Palmer
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (5): e202513821.
https://doi.org/10.1085/jgp.202513821
Published: 12 August 2025
View article titled, Kinetics of aldosterone-dependent ENaC trafficking in the kidney
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Includes: Supplementary data
Journal Articles

GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains

Rebeca Martínez-Lázaro, Teresa Minguez-Viñas, Andrea Reyes-Carrión, Ricardo Gómez, Diego Alvarez de la Rosa, David Bartolomé-Martín, Teresa Giraldez
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (5): e202513799.
https://doi.org/10.1085/jgp.202513799
Published: 05 August 2025
View article titled, GRIN2B disease-associated mutations disrupt the function of BK channels and NMDA receptor signaling nanodomains
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Includes: Supplementary data
Journal Articles

Variability in reported midpoints of (in)activation of cardiac INa

Michael Clerx, Paul G.A. Volders, Gary R. Mirams
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (5): e202413621.
https://doi.org/10.1085/jgp.202413621
Published: 16 July 2025
View article titled, Variability in reported midpoints of (in)activation of cardiac INa
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Includes: Supplementary data
Journal Articles

Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44

David Gong, Jennifer L. Orthmann-Murphy, Deepak Kumar, Gabriel D. Dungan, Ayman W. El-Hattab, Nicoline Schiess, Yun L. Luo, Mona M. Freidin, Charles K. Abrams
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (4): e202413617.
https://doi.org/10.1085/jgp.202413617
Published: 10 June 2025
View article titled, Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44
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Includes: Supplementary data
Journal Articles

Obscurin deficiency leads to compensated dilated cardiomyopathy and increased arrhythmias

Josè Manuel Pioner, Enrico Pierantozzi, Raffaele Coppini, Egidio Maria Rubino, Valentina Biasci, Giulia Vitale, Annunziatina Laurino, Lorenzo Santini, Marina Scardigli, Davide Randazzo, Camilla Olianti, Matteo Serano, Daniela Rossi, Chiara Tesi, Elisabetta Cerbai, Stephan Lange, Carlo Reggiani, Leonardo Sacconi, Corrado Poggesi, Cecilia Ferrantini, Vincenzo Sorrentino
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (4): e202413696.
https://doi.org/10.1085/jgp.202413696
Published: 14 May 2025
View article titled, Obscurin deficiency leads to compensated dilated cardiomyopathy and increased arrhythmias
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Includes: Supplementary data
Journal Articles

Loss of intracellular FGF14 (iFGF14) increases excitability of mature hippocampal pyramidal neurons

Joseph L. Ransdell, Yarimar Carrasquillo, Marie K. Bosch, Rebecca L. Mellor, David M. Ornitz, Jeanne M. Nerbonne
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (4): e202413597.
https://doi.org/10.1085/jgp.202413597
Published: 05 May 2025
View article titled, Loss of intracellular FGF14 (iFGF14) increases excitability of mature hippocampal pyramidal neurons
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Includes: Supplementary data
Journal Articles

The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses

In Special Collection:
Neuroscience Collection 2025
Wallace B. Thoreson, Thomas M. Bartol, Nicholas H. Conoan, Jeffrey S. Diamond
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413746.
https://doi.org/10.1085/jgp.202413746
Published: 28 February 2025
View article titled, The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses
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Journal Articles

ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells

In Special Collection:
Neuroscience Collection 2025
Evelyn C. Avilés, Sean K. Wang, Sarina Patel, Sebastian Cordero, Shuxiang Shi, Lucas Lin, Vladimir J. Kefalov, Lisa V. Goodrich, Constance L. Cepko, Yunlu Xue
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (2): e202413642.
https://doi.org/10.1085/jgp.202413642
Published: 04 February 2025
View article titled, ERG responses to high-frequency flickers require FAT3 signaling in mouse retinal bipolar cells
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Includes: Supplementary data
Journal Articles

Inactivation of CaV1 and CaV2 channels

Worawan B. Limpitikul, Ivy E. Dick
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (2): e202313531.
https://doi.org/10.1085/jgp.202313531
Published: 30 January 2025
View article titled, Inactivation of CaV1 and CaV2 channels
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Journal Articles

Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials

In Special Collection:
Neuroscience Collection 2025
Phil Alexander Köster, Enrico Leipold, Jenny Tigerholm, Anna Maxion, Barbara Namer, Thomas Stiehl, Angelika Lampert
Journal: Journal of General Physiology
Series: Pain Focus
J Gen Physiol (2025) 157 (2): e202313526.
https://doi.org/10.1085/jgp.202313526
Published: 21 January 2025
View article titled, Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials
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Includes: Supplementary data
Journal Articles

Reduced voltage-activated Ca2+ release flux in muscle fibers from a rat model of Duchenne dystrophy

Jonathan Schreiber, Ludivine Rotard, Yves Tourneur, Aude Lafoux, Christine Berthier, Bruno Allard, Corinne Huchet, Vincent Jacquemond
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (2): e202413588.
https://doi.org/10.1085/jgp.202413588
Published: 24 December 2024
View article titled, Reduced voltage-activated Ca2+ release flux in muscle fibers from a rat model of Duchenne dystrophy
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Journal Articles

Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers

In Special Collection:
JGP Highlights Collection 2025
Smriti Gupta, Yu-Hsin Chiu, Mohan C. Manjegowda, Bimal N. Desai, Kodi S. Ravichandran, Douglas A. Bayliss
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413676.
https://doi.org/10.1085/jgp.202413676
Published: 20 December 2024
View article titled, Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers
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Journal Articles

How does mitochondrial Ca2+ change during ischemia and reperfusion? Implications for activation of the permeability transition pore

Elizabeth Murphy, David A. Eisner
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202313520.
https://doi.org/10.1085/jgp.202313520
Published: 19 December 2024
View article titled, How does mitochondrial Ca2+ change during ischemia and reperfusion? Implications for activation of the permeability transition pore
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Journal Articles

Intrinsic adaptive plasticity in mouse and human sensory neurons

In Special Collection:
Neuroscience Collection 2025
Lisa A. McIlvried, John Smith Del Rosario, Melanie Y. Pullen, Andi Wangzhou, Tayler D. Sheahan, Andrew J. Shepherd, Richard A. Slivicki, John A. Lemen, Theodore J. Price, Bryan A. Copits, Robert W. Gereau, IV
Journal: Journal of General Physiology
Series: Pain Focus
J Gen Physiol (2024) 157 (1): e202313488.
https://doi.org/10.1085/jgp.202313488
Published: 17 December 2024
View article titled, Intrinsic adaptive plasticity in mouse and human sensory neurons
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Journal Articles

Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina

In Special Collection:
Neuroscience Collection 2025
Olga Chernyshkova, Natalia Erofeeva, Darya Meshalkina, Anna Balykina, Stepan Gambaryan, Michael Belyakov, Michael Firsov
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (11): e202313530.
https://doi.org/10.1085/jgp.202313530
Published: 22 October 2024
View article titled, Light induces a rapid increase in cAMP and activates PKA in rod outer segments of the frog retina
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Includes: Supplementary data