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Journal Articles

Mechanistic insights into DCPIB inhibition of VRAC: Electrostatic control and binding plasticity

Héctor Gaitán-Peñas, Salomé Llabrés, Marina Pedrola, Marc González-Subías, Jordi Juárez-Jiménez, Michael Pusch, Rodolfo Lavilla, Raúl Estévez
Journal: Journal of General Physiology
Series: Chloride Channels and Transporters
J Gen Physiol (2026) 158 (5): e202513953.
https://doi.org/10.1085/jgp.202513953
Published: 25 June 2026
View article titled, Mechanistic insights into DCPIB inhibition of VRAC: Electrostatic control and binding plasticity
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Includes: Supplementary data
Journal Articles

Evolution of our understanding of the sodium channel fast inactivation: From Hodgkin and Huxley to the structural era

Yichen Liu, Cesar A. Amaya-Rodriguez, Victoria Collio, Gabriel Ibañez, Ramón Latorre, Francisco Bezanilla
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels 2026
J Gen Physiol (2026) 158 (4): e202613980.
https://doi.org/10.1085/jgp.202613980
Published: 07 May 2026
View article titled, Evolution of our understanding of the sodium channel fast inactivation: From Hodgkin and Huxley to the structural era
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Journal Articles

Combining elastic network models and linear response theory as tool to understand the global dynamics in allosteric regulation of HCN channels

Magnus Behringer, Jan Krumbach, Alessandro Porro, Andrea Saponaro, Dario DiFrancesco, Anna Moroni, Kay Hamacher, Gerhard Thiel
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202513899.
https://doi.org/10.1085/jgp.202513899
Published: 03 April 2026
View article titled, Combining elastic network models and linear response theory as tool to understand the global dynamics in allosteric regulation of HCN channels
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Journal Articles

Molecular dynamics analyses of CLDN15 pore size and charge selectivity

Sarah McGuinness, Pan Li, Ye Li, Shadi Fuladi, Sukanya Konar, Samaneh Sajjadi, Mohammed Sidahmed, Yueying Li, Le Shen, Fatemeh Khalili-Araghi, Christopher R. Weber
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (2): e202513824.
https://doi.org/10.1085/jgp.202513824
Published: 12 February 2026
View article titled, Molecular dynamics analyses of CLDN15 pore size and charge selectivity
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Journal Articles

A critical residue mediates proper assembly and gating of GIRK2 channels

Ha Nguyen, Jonathan Mount, Keino Hutchinson, Yihan Zhao, Yulin Zhao, Ian W. Glaaser, Peng Yuan, Avner Schlessinger, Paul A. Slesinger
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513817.
https://doi.org/10.1085/jgp.202513817
Published: 19 December 2025
View article titled, A critical residue mediates proper assembly and gating of GIRK2 channels
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Includes: Supplementary data
Journal Articles

Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2

Diego Lopez-Mateos, Kush Narang, Vladimir Yarov-Yarovoy
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels 2026
J Gen Physiol (2025) 158 (2): e202413705.
https://doi.org/10.1085/jgp.202413705
Published: 18 December 2025
View article titled, Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2
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Includes: Supplementary data
Journal Articles

On the mechanism of K+ transport through the inter-subunit tunnel of KdpFABC

Hridya Valia Madapally, Adel Hussein, Martin Wazar Eriksen, Bjørn Panyella Pedersen, David L. Stokes, Himanshu Khandelia
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513794.
https://doi.org/10.1085/jgp.202513794
Published: 12 December 2025
View article titled, On the mechanism of K+ transport through the inter-subunit tunnel of KdpFABC
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Includes: Supplementary data
Journal Articles

Novel binding mode for negative allosteric NMDA receptor modulators

James S. Lotti, Jed T. Syrenne, Avery J. Benton, Ahmad Al-Mousawi, Lauren E. Cornelison, Christopher J. Trolinder, Feng Yi, Zhucheng Zhang, Cindee K. Yates-Hansen, Levi J. McClelland, James Bosco, Andrew R. Rau, Rasmus P. Clausen, Kasper B. Hansen
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513872.
https://doi.org/10.1085/jgp.202513872
Published: 03 December 2025
View article titled, Novel binding mode for negative allosteric NMDA receptor modulators
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Includes: Supplementary data
Journal Articles

Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel

Akshay Sharma, Christopher Marra, Nomon Mohammad, Vasilisa Iatckova, Lillian Lawrence, Mitchell Goldfarb
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513835.
https://doi.org/10.1085/jgp.202513835
Published: 02 December 2025
View article titled, Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel
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Includes: Supplementary data
Journal Articles

Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit

Daniela De Giorgis, Guido Mellado, Jose Antonio Garate, Alan Neely
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202413739.
https://doi.org/10.1085/jgp.202413739
Published: 05 November 2025
View article titled, Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit
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Includes: Supplementary data
Journal Articles

PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating

Eva-Maria Zangerl-Plessl, Anna Stary-Weinzinger, Colin G. Nichols, Sun-Joo Lee
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (6): e202513864.
https://doi.org/10.1085/jgp.202513864
Published: 03 October 2025
View article titled, PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating
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Journal Articles

NALCN/Cch1 channelosome subunits originated in early eukaryotes

Adriano Senatore, Tatiana D. Mayorova, Luis A. Yañez-Guerra, Wassim Elkhatib, Brian Bejoy, Philippe Lory, Arnaud Monteil
Journal: Journal of General Physiology
Series: Molecular evolution in the membrane
J Gen Physiol (2025) 157 (6): e202413636.
https://doi.org/10.1085/jgp.202413636
Published: 05 September 2025
View article titled, NALCN/Cch1 channelosome subunits originated in early eukaryotes
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Includes: Supplementary data
Journal Articles

Exploring a peripheral PIP2-binding site and its role in the alternative regulation of the TRP channel superfamily

L. Gonzalo Espinoza-Arcos, Mariela González-Avendaño, Matías Zuñiga-Bustos, Ricardo A. Zamora, Ariela Vergara-Jaque, Horacio Poblete
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (6): e202413574.
https://doi.org/10.1085/jgp.202413574
Published: 22 August 2025
View article titled, Exploring a peripheral PIP2-binding site and its role in the alternative regulation of the TRP channel superfamily
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Includes: Supplementary data
Journal Articles

Charybdotoxin binding to Shaker K+ channels is temperature sensitive in high external K+ but not in high external Na+

Nieves Navarro-Quezada, Francisca Salas-Sepulveda, Horacio Poblete, David Naranjo
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (5): e202413590.
https://doi.org/10.1085/jgp.202413590
Published: 07 August 2025
View article titled, Charybdotoxin binding to Shaker K+ channels is temperature sensitive in high external K+ but not in high external Na+
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Includes: Supplementary data
Journal Articles

Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44

David Gong, Jennifer L. Orthmann-Murphy, Deepak Kumar, Gabriel D. Dungan, Ayman W. El-Hattab, Nicoline Schiess, Yun L. Luo, Mona M. Freidin, Charles K. Abrams
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (4): e202413617.
https://doi.org/10.1085/jgp.202413617
Published: 10 June 2025
View article titled, Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44
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Includes: Supplementary data
Journal Articles

Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini

Yu Zhou, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (4): e202513790.
https://doi.org/10.1085/jgp.202513790
Published: 30 May 2025
View article titled, Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini
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Includes: Supplementary data
Journal Articles

Prediction and biological significance of small changes in binding of leiomodin to tropomyosin

Eduardo Sánchez Díaz, Brayan Osegueda, Svetlana Minakhina, Nickolas Starks, Stefanie Novak, Dmitri Tolkatchev, Carol C. Gregorio, Alla S. Kostyukova, Garry E. Smith, Jr
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (4): e202413641.
https://doi.org/10.1085/jgp.202413641
Published: 24 April 2025
View article titled, Prediction and biological significance of small changes in binding of leiomodin to tropomyosin
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Includes: Supplementary data
Journal Articles

In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel

Alp Tegin Şahin, Ulrich Zachariae
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202313506.
https://doi.org/10.1085/jgp.202313506
Published: 21 February 2025
View article titled, In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel
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Includes: Supplementary data
Journal Articles

Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy

John H. Lewis, Yufeng Zhou, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413709.
https://doi.org/10.1085/jgp.202413709
Published: 20 February 2025
View article titled, Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy
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Includes: Supplementary data
Journal Articles

Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease

Maya Noureddine, Halina Mikolajek, Neil V. Morgan, Chris Denning, Siobhan Loughna, Katja Gehmlich, Fiyaz Mohammed
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (2): e202413684.
https://doi.org/10.1085/jgp.202413684
Published: 07 February 2025
View article titled, Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease
Open the PDF for Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease in another window
Includes: Supplementary data

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