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Journal Articles

A critical residue mediates proper assembly and gating of GIRK2 channels

Ha Nguyen, Jonathan Mount, Keino Hutchinson, Yihan Zhao, Yulin Zhao, Ian W. Glaaser, Peng Yuan, Avner Schlessinger, Paul A. Slesinger

J Gen Physiol (2025) 158 (1): e202513817.

https://doi.org/10.1085/jgp.202513817

Published: 19 December 2025

View article titled, A critical residue mediates proper assembly and gating of GIRK2 channels

Includes: Supplementary data

Journal Articles

Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2

Diego Lopez-Mateos, Kush Narang, Vladimir Yarov-Yarovoy

J Gen Physiol (2025) 158 (2): e202413705.

https://doi.org/10.1085/jgp.202413705

Published: 18 December 2025

View article titled, Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2

Includes: Supplementary data

Journal Articles

On the mechanism of K⁺ transport through the inter-subunit tunnel of KdpFABC

Hridya Valia Madapally, Adel Hussein, Martin Wazar Eriksen, Bjørn Panyella Pedersen, David L. Stokes, Himanshu Khandelia

J Gen Physiol (2025) 158 (1): e202513794.

https://doi.org/10.1085/jgp.202513794

Published: 12 December 2025

View article titled, On the mechanism of K+ transport through the inter-subunit tunnel of KdpFABC

Includes: Supplementary data

Journal Articles

Novel binding mode for negative allosteric NMDA receptor modulators

James S. Lotti, Jed T. Syrenne, Avery J. Benton, Ahmad Al-Mousawi, Lauren E. Cornelison, Christopher J. Trolinder, Feng Yi, Zhucheng Zhang, Cindee K. Yates-Hansen, Levi J. McClelland, James Bosco, Andrew R. Rau, Rasmus P. Clausen, Kasper B. Hansen

J Gen Physiol (2025) 158 (1): e202513872.

https://doi.org/10.1085/jgp.202513872

Published: 03 December 2025

View article titled, Novel binding mode for negative allosteric NMDA receptor modulators

Includes: Supplementary data

Journal Articles

Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel

Akshay Sharma, Christopher Marra, Nomon Mohammad, Vasilisa Iatckova, Lillian Lawrence, Mitchell Goldfarb

J Gen Physiol (2025) 158 (1): e202513835.

https://doi.org/10.1085/jgp.202513835

Published: 02 December 2025

View article titled, Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel

Includes: Supplementary data

Journal Articles

Regulation of voltage-sensing structures of Ca_V1.2 calcium channel by the auxiliary β₃-subunit

Daniela De Giorgis, Guido Mellado, Jose Antonio Garate, Alan Neely

J Gen Physiol (2025) 158 (1): e202413739.

https://doi.org/10.1085/jgp.202413739

Published: 05 November 2025

View article titled, Regulation of voltage-sensing structures of CaV1.2 calcium channel by the auxiliary β3-subunit

Includes: Supplementary data

Journal Articles

PIP₂-driven cytoplasmic domain motions are coupled to Kir2 channel gating

Eva-Maria Zangerl-Plessl, Anna Stary-Weinzinger, Colin G. Nichols, Sun-Joo Lee

J Gen Physiol (2025) 157 (6): e202513864.

https://doi.org/10.1085/jgp.202513864

Published: 03 October 2025

View article titled, PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating

Journal Articles

NALCN/Cch1 channelosome subunits originated in early eukaryotes

Adriano Senatore, Tatiana D. Mayorova, Luis A. Yañez-Guerra, Wassim Elkhatib, Brian Bejoy, Philippe Lory, Arnaud Monteil

J Gen Physiol (2025) 157 (6): e202413636.

https://doi.org/10.1085/jgp.202413636

Published: 05 September 2025

View article titled, NALCN/Cch1 channelosome subunits originated in early eukaryotes

Includes: Supplementary data

Journal Articles

Exploring a peripheral PIP₂-binding site and its role in the alternative regulation of the TRP channel superfamily

L. Gonzalo Espinoza-Arcos, Mariela González-Avendaño, Matías Zuñiga-Bustos, Ricardo A. Zamora, Ariela Vergara-Jaque, Horacio Poblete

J Gen Physiol (2025) 157 (6): e202413574.

https://doi.org/10.1085/jgp.202413574

Published: 22 August 2025

View article titled, Exploring a peripheral PIP2-binding site and its role in the alternative regulation of the TRP channel superfamily

Includes: Supplementary data

Journal Articles

Charybdotoxin binding to Shaker K⁺ channels is temperature sensitive in high external K⁺ but not in high external Na⁺

Nieves Navarro-Quezada, Francisca Salas-Sepulveda, Horacio Poblete, David Naranjo

J Gen Physiol (2025) 157 (5): e202413590.

https://doi.org/10.1085/jgp.202413590

Published: 07 August 2025

View article titled, Charybdotoxin binding to Shaker K+ channels is temperature sensitive in high external K+ but not in high external Na+

Includes: Supplementary data

Journal Articles

Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44

David Gong, Jennifer L. Orthmann-Murphy, Deepak Kumar, Gabriel D. Dungan, Ayman W. El-Hattab, Nicoline Schiess, Yun L. Luo, Mona M. Freidin, Charles K. Abrams

J Gen Physiol (2025) 157 (4): e202413617.

https://doi.org/10.1085/jgp.202413617

Published: 10 June 2025

View article titled, Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44

Includes: Supplementary data

Journal Articles

Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini

Yu Zhou, Xiao-Ming Xia, Christopher J. Lingle

J Gen Physiol (2025) 157 (4): e202513790.

https://doi.org/10.1085/jgp.202513790

Published: 30 May 2025

View article titled, Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini

Includes: Supplementary data

Journal Articles

Prediction and biological significance of small changes in binding of leiomodin to tropomyosin

Eduardo Sánchez Díaz, Brayan Osegueda, Svetlana Minakhina, Nickolas Starks, Stefanie Novak, Dmitri Tolkatchev, Carol C. Gregorio, Alla S. Kostyukova, Garry E. Smith, Jr

J Gen Physiol (2025) 157 (4): e202413641.

https://doi.org/10.1085/jgp.202413641

Published: 24 April 2025

View article titled, Prediction and biological significance of small changes in binding of leiomodin to tropomyosin

Includes: Supplementary data

Journal Articles

In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel

Alp Tegin Şahin, Ulrich Zachariae

J Gen Physiol (2025) 157 (3): e202313506.

https://doi.org/10.1085/jgp.202313506

Published: 21 February 2025

View article titled, In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel

Includes: Supplementary data

Journal Articles

Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy

John H. Lewis, Yufeng Zhou, Zhe Lu

J Gen Physiol (2025) 157 (3): e202413709.

https://doi.org/10.1085/jgp.202413709

Published: 20 February 2025

View article titled, Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy

Includes: Supplementary data

Journal Articles

Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease

Maya Noureddine, Halina Mikolajek, Neil V. Morgan, Chris Denning, Siobhan Loughna, Katja Gehmlich, Fiyaz Mohammed

J Gen Physiol (2025) 157 (2): e202413684.

https://doi.org/10.1085/jgp.202413684

Published: 07 February 2025

View article titled, Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease

Includes: Supplementary data

Journal Articles

The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels

Eslam Elhanafy, Amin Akbari Ahangar, Rebecca Roth, Tamer M. Gamal El-Din, John R. Bankston, Jing Li

J Gen Physiol (2025) 157 (2): e202413669.

https://doi.org/10.1085/jgp.202413669

Published: 17 January 2025

View article titled, The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels

Includes: Supplementary data

Journal Articles

Drugs exhibit diverse binding modes and access routes in the Na_v1.5 cardiac sodium channel pore

Elaine Tao, Ben Corry

J Gen Physiol (2025) 157 (2): e202413658.

https://doi.org/10.1085/jgp.202413658

Published: 07 January 2025

View article titled, Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore

Journal Articles

ALLIN: A tool for annotation of a protein alignment combined with structural visualization

Alessandra Picollo, Michael Pusch

J Gen Physiol (2024) 157 (2): e202413635.

https://doi.org/10.1085/jgp.202413635

Published: 31 December 2024

View article titled, ALLIN: A tool for annotation of a protein alignment combined with structural visualization

Journal Articles

The calcium-binding protein S100A1 binds to titin’s N2A insertion sequence in a pH-dependent manner

Sabrina I. Apel, Emily Schaffter, Nicholas Melisi, Matthew J. Gage

J Gen Physiol (2024) 157 (1): e202313472.

https://doi.org/10.1085/jgp.202313472

Published: 31 December 2024

View article titled, The calcium-binding protein S100A1 binds to titin’s N2A insertion sequence in a pH-dependent manner

Includes: Supplementary data

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Date

A critical residue mediates proper assembly and gating of GIRK2 channels

Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2

On the mechanism of K⁺ transport through the inter-subunit tunnel of KdpFABC

Novel binding mode for negative allosteric NMDA receptor modulators

Carboxyl-terminal domain missense mutations alter distinct properties of the cardiac sodium channel

Regulation of voltage-sensing structures of Ca_V1.2 calcium channel by the auxiliary β₃-subunit

PIP₂-driven cytoplasmic domain motions are coupled to Kir2 channel gating

NALCN/Cch1 channelosome subunits originated in early eukaryotes

Exploring a peripheral PIP₂-binding site and its role in the alternative regulation of the TRP channel superfamily

Charybdotoxin binding to Shaker K⁺ channels is temperature sensitive in high external K⁺ but not in high external Na⁺

Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44

Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini

Prediction and biological significance of small changes in binding of leiomodin to tropomyosin

In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel

Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy

Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease

The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels

Drugs exhibit diverse binding modes and access routes in the Na_v1.5 cardiac sodium channel pore

ALLIN: A tool for annotation of a protein alignment combined with structural visualization

The calcium-binding protein S100A1 binds to titin’s N2A insertion sequence in a pH-dependent manner

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