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Journal Articles

The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels

Eslam Elhanafy, Amin Akbari Ahangar, Rebecca Roth, Tamer M. Gamal El-Din, John R. Bankston, Jing Li
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413669.
https://doi.org/10.1085/jgp.202413669
Published: 17 January 2025
View article titled, The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels
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Includes: Supplementary data
Journal Articles

Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore

Elaine Tao, Ben Corry
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413658.
https://doi.org/10.1085/jgp.202413658
Published: 07 January 2025
View article titled, Drugs exhibit diverse binding modes and access routes in the Na<sub>v</sub>1.5 cardiac sodium channel pore
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Journal Articles

The calcium-binding protein S100A1 binds to titin’s N2A insertion sequence in a pH-dependent manner

Sabrina I. Apel, Emily Schaffter, Nicholas Melisi, Matthew J. Gage
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202313472.
https://doi.org/10.1085/jgp.202313472
Published: 31 December 2024
View article titled, The calcium-binding protein S100A1 binds to titin’s N2A insertion sequence in a pH-dependent manner
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Includes: Supplementary data
Journal Articles

ALLIN: A tool for annotation of a protein alignment combined with structural visualization

Alessandra Picollo, Michael Pusch
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (2): e202413635.
https://doi.org/10.1085/jgp.202413635
Published: 31 December 2024
View article titled, ALLIN: A tool for annotation of a protein alignment combined with structural visualization
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Journal Articles

Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites

Christopher A. Beaudoin, Manas Kohli, Samantha C. Salvage, Hengrui Liu, Samuel J. Arundel, Samir W. Hamaia, Ming Lei, Christopher L.-H. Huang, Antony P. Jackson
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2024) 157 (1): e202413609.
https://doi.org/10.1085/jgp.202413609
Published: 16 December 2024
View article titled, Isoform-specific N-linked glycosylation of Na<sub>V</sub> channel α-subunits alters β-subunit binding sites
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Journal Articles

Structure and selectivity of a glutamate-specific TAXI TRAP binding protein from Vibrio cholerae

Joseph F.S. Davies, Andrew Daab, Nicholas Massouh, Corey Kirkland, Bernadette Strongitharm, Andrew Leech, Marta Farré, Gavin H. Thomas, Christopher Mulligan
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202413584.
https://doi.org/10.1085/jgp.202413584
Published: 18 November 2024
View article titled, Structure and selectivity of a glutamate-specific TAXI TRAP binding protein from Vibrio cholerae
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Includes: Supplementary data
Journal Articles

Stable oxidative posttranslational modifications alter the gating properties of RyR1

Maarten M. Steinz, Nicole Beard, Emily Shorter, Johanna T. Lanner
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202313515.
https://doi.org/10.1085/jgp.202313515
Published: 05 November 2024
View article titled, Stable oxidative posttranslational modifications alter the gating properties of RyR1
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Includes: Supplementary data
Journal Articles

Mechanism of acid-sensing ion channel modulation by Hi1a

Kyle D. Berger, David M. MacLean
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202313519.
https://doi.org/10.1085/jgp.202313519
Published: 24 October 2024
View article titled, Mechanism of acid-sensing ion channel modulation by Hi1a
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Includes: Supplementary data
Journal Articles

A pore locus in the E1 domain differentially regulates Cx26 and Cx30 hemichannel function

Helmuth A. Sanchez, Lina Kraujaliene, Vytas K. Verselis
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (11): e202313502.
https://doi.org/10.1085/jgp.202313502
Published: 20 September 2024
View article titled, A pore locus in the E1 domain differentially regulates Cx26 and Cx30 hemichannel function
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Journal Articles

An Ala/Glu difference in E1 of Cx26 and Cx30 contributes to their differential anionic permeabilities

Lina Kraujaliene, Tadas Kraujalis, Mindaugas Snipas, Vytas K. Verselis
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (11): e202413600.
https://doi.org/10.1085/jgp.202413600
Published: 20 September 2024
View article titled, An Ala/Glu difference in E1 of Cx26 and Cx30 contributes to their differential anionic permeabilities
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Includes: Supplementary data
Journal Articles

Different fluorescent labels report distinct components of spHCN channel voltage sensor movement

Magdalena N. Wojciechowski, Chaseley E. McKenzie, Andrew Hung, Alibek Kuanyshbek, Ming S. Soh, Christopher A. Reid, Ian C. Forster
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (8): e202413559.
https://doi.org/10.1085/jgp.202413559
Published: 05 July 2024
View article titled, Different fluorescent labels report distinct components of spHCN channel voltage sensor movement
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Includes: Supplementary data
Journal Articles

Hydrophobic residues in S1 modulate enzymatic function and voltage sensing in voltage-sensing phosphatase

In Special Collection:
Molecular Insights into Membrane Protein Function
Vamseedhar Rayaprolu, Heini M. Miettinen, William D. Baker, Victoria C. Young, Matthew Fisher, Gwendolyn Mueller, William O. Rankin, John T. Kelley, William J. Ratzan, Lee Min Leong, Joshua A. Davisson, Bradley J. Baker, Susy C. Kohout
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (7): e202313467.
https://doi.org/10.1085/jgp.202313467
Published: 21 May 2024
View article titled, Hydrophobic residues in S1 modulate enzymatic function and voltage sensing in voltage-sensing phosphatase
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Includes: Supplementary data
Journal Articles

Tail length and E525K dilated cardiomyopathy mutant alter human β-cardiac myosin super-relaxed state

Sebastian Duno-Miranda, Shane R. Nelson, David V. Rasicci, Skylar M.L. Bodt, Joseph A. Cirilo, Jr, Duha Vang, Sivaraj Sivaramakrishnan, Christopher M. Yengo, David M. Warshaw
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (6): e202313522.
https://doi.org/10.1085/jgp.202313522
Published: 06 May 2024
View article titled, Tail length and E525K dilated cardiomyopathy mutant alter human β-cardiac myosin super-relaxed state
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Includes: Supplementary data
Journal Articles

Mutation in pore-helix modulates interplay between filter gate and Ba2+ block in a Kcv channel pore

Noel Tewes, Beatrice Kubitzki, Flandrit Bytyqi, Nikola Metko, Sebastian Mach, Gerhard Thiel, Oliver Rauh
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (5): e202313514.
https://doi.org/10.1085/jgp.202313514
Published: 23 April 2024
View article titled, Mutation in pore-helix modulates interplay between filter gate and Ba<sup>2+</sup> block in a Kcv channel pore
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Journal Articles

Transport of metformin metabolites by guanidinium exporters of the small multidrug resistance family

In Special Collection:
Molecular Insights into Membrane Protein Function
Rachael M. Lucero, Kemal Demirer, Trevor Justin Yeh, Randy B. Stockbridge
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (3): e202313464.
https://doi.org/10.1085/jgp.202313464
Published: 31 January 2024
View article titled, Transport of metformin metabolites by guanidinium exporters of the small multidrug resistance family
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Includes: Supplementary data
Journal Articles

Effect of a sensing charge mutation on the deactivation of KV7.2 channels

In Special Collection:
Neuroscience Collection 2024
Baharak Mehrdel, Carlos A. Villalba-Galea
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (3): e202213284.
https://doi.org/10.1085/jgp.202213284
Published: 18 January 2024
View article titled, Effect of a sensing charge mutation on the deactivation of K<sub>V</sub>7.2 channels
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Journal Articles

Asymmetric contribution of a selectivity filter gate in triggering inactivation of CaV1.3 channels

Pedro J. del Rivero Morfin, Audrey L. Kochiss, Klaus R. Liedl, Bernhard E. Flucher, Monica L.I. Fernández-Quintero, Manu Ben-Johny
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (2): e202313365.
https://doi.org/10.1085/jgp.202313365
Published: 04 January 2024
View article titled, Asymmetric contribution of a selectivity filter gate in triggering inactivation of Ca<sub>V</sub>1.3 channels
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Journal Articles

Mechanism of hydrophobic gating in the acetylcholine receptor channel pore

Monika Kumari, Nadira Khatoon, Rachita Sharma, Sushanth Adusumilli, Anthony Auerbach, Hemant K. Kashyap, Tapan K. Nayak
Journal: Journal of General Physiology
J Gen Physiol (2023) 156 (2): e202213189.
https://doi.org/10.1085/jgp.202213189
Published: 28 December 2023
View article titled, Mechanism of hydrophobic gating in the acetylcholine receptor channel pore
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Includes: Supplementary data
Journal Articles

Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP

Rong Shen, Benoît Roux, Eduardo Perozo
Journal: Journal of General Physiology
J Gen Physiol (2023) 156 (1): e202213311.
https://doi.org/10.1085/jgp.202213311
Published: 29 November 2023
View article titled, Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP
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Journal Articles

Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7

In Special Collection:
Biophysics 2024 , Neuroscience Collection 2024
Goragot Wisedchaisri, Tamer M. Gamal El-Din, Natasha M. Powell, Ning Zheng, William A. Catterall
Journal: Journal of General Physiology
Series: Pain Focus
J Gen Physiol (2023) 155 (12): e202313450.
https://doi.org/10.1085/jgp.202313450
Published: 30 October 2023
View article titled, Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel Na<sub>V</sub>1.7
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Includes: Supplementary data