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Journal Articles

Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44

David Gong, Jennifer L. Orthmann-Murphy, Deepak Kumar, Gabriel D. Dungan, Ayman W. El-Hattab, Nicoline Schiess, Yun L. Luo, Mona M. Freidin, Charles K. Abrams
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (4): e202413617.
https://doi.org/10.1085/jgp.202413617
Published: 10 June 2025
View article titled, Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44
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Includes: Supplementary data
Journal Articles

Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini

Yu Zhou, Xiao-Ming Xia, Christopher J. Lingle
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (4): e202513790.
https://doi.org/10.1085/jgp.202513790
Published: 30 May 2025
View article titled, Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N termini
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Includes: Supplementary data
Journal Articles

Prediction and biological significance of small changes in binding of leiomodin to tropomyosin

Eduardo Sánchez Díaz, Brayan Osegueda, Svetlana Minakhina, Nickolas Starks, Stefanie Novak, Dmitri Tolkatchev, Carol C. Gregorio, Alla S. Kostyukova, Garry E. Smith, Jr
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (4): e202413641.
https://doi.org/10.1085/jgp.202413641
Published: 24 April 2025
View article titled, Prediction and biological significance of small changes in binding of leiomodin to tropomyosin
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Includes: Supplementary data
Journal Articles

In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel

Alp Tegin Şahin, Ulrich Zachariae
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202313506.
https://doi.org/10.1085/jgp.202313506
Published: 21 February 2025
View article titled, In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel
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Includes: Supplementary data
Journal Articles

Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy

John H. Lewis, Yufeng Zhou, Zhe Lu
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413709.
https://doi.org/10.1085/jgp.202413709
Published: 20 February 2025
View article titled, Examination of conformational dynamics of AdiC transporter with fluorescence-polarization microscopy
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Includes: Supplementary data
Journal Articles

Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease

Maya Noureddine, Halina Mikolajek, Neil V. Morgan, Chris Denning, Siobhan Loughna, Katja Gehmlich, Fiyaz Mohammed
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (2): e202413684.
https://doi.org/10.1085/jgp.202413684
Published: 07 February 2025
View article titled, Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease
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Includes: Supplementary data
Journal Articles

The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels

Eslam Elhanafy, Amin Akbari Ahangar, Rebecca Roth, Tamer M. Gamal El-Din, John R. Bankston, Jing Li
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413669.
https://doi.org/10.1085/jgp.202413669
Published: 17 January 2025
View article titled, The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels
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Includes: Supplementary data
Journal Articles

Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore

Elaine Tao, Ben Corry
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413658.
https://doi.org/10.1085/jgp.202413658
Published: 07 January 2025
View article titled, Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore
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Journal Articles

The calcium-binding protein S100A1 binds to titin’s N2A insertion sequence in a pH-dependent manner

Sabrina I. Apel, Emily Schaffter, Nicholas Melisi, Matthew J. Gage
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202313472.
https://doi.org/10.1085/jgp.202313472
Published: 31 December 2024
View article titled, The calcium-binding protein S100A1 binds to titin’s N2A insertion sequence in a pH-dependent manner
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Includes: Supplementary data
Journal Articles

ALLIN: A tool for annotation of a protein alignment combined with structural visualization

Alessandra Picollo, Michael Pusch
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (2): e202413635.
https://doi.org/10.1085/jgp.202413635
Published: 31 December 2024
View article titled, ALLIN: A tool for annotation of a protein alignment combined with structural visualization
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Journal Articles

Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites

Christopher A. Beaudoin, Manas Kohli, Samantha C. Salvage, Hengrui Liu, Samuel J. Arundel, Samir W. Hamaia, Ming Lei, Christopher L.-H. Huang, Antony P. Jackson
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2024) 157 (1): e202413609.
https://doi.org/10.1085/jgp.202413609
Published: 16 December 2024
View article titled, Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites
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Journal Articles

Structure and selectivity of a glutamate-specific TAXI TRAP binding protein from Vibrio cholerae

Joseph F.S. Davies, Andrew Daab, Nicholas Massouh, Corey Kirkland, Bernadette Strongitharm, Andrew Leech, Marta Farré, Gavin H. Thomas, Christopher Mulligan
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202413584.
https://doi.org/10.1085/jgp.202413584
Published: 18 November 2024
View article titled, Structure and selectivity of a glutamate-specific TAXI TRAP binding protein from Vibrio cholerae
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Includes: Supplementary data
Journal Articles

Stable oxidative posttranslational modifications alter the gating properties of RyR1

Maarten M. Steinz, Nicole Beard, Emily Shorter, Johanna T. Lanner
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202313515.
https://doi.org/10.1085/jgp.202313515
Published: 05 November 2024
View article titled, Stable oxidative posttranslational modifications alter the gating properties of RyR1
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Includes: Supplementary data
Journal Articles

Mechanism of acid-sensing ion channel modulation by Hi1a

Kyle D. Berger, David M. MacLean
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202313519.
https://doi.org/10.1085/jgp.202313519
Published: 24 October 2024
View article titled, Mechanism of acid-sensing ion channel modulation by Hi1a
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Includes: Supplementary data
Journal Articles

A pore locus in the E1 domain differentially regulates Cx26 and Cx30 hemichannel function

Helmuth A. Sanchez, Lina Kraujaliene, Vytas K. Verselis
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (11): e202313502.
https://doi.org/10.1085/jgp.202313502
Published: 20 September 2024
View article titled, A pore locus in the E1 domain differentially regulates Cx26 and Cx30 hemichannel function
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Journal Articles

An Ala/Glu difference in E1 of Cx26 and Cx30 contributes to their differential anionic permeabilities

Lina Kraujaliene, Tadas Kraujalis, Mindaugas Snipas, Vytas K. Verselis
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (11): e202413600.
https://doi.org/10.1085/jgp.202413600
Published: 20 September 2024
View article titled, An Ala/Glu difference in E1 of Cx26 and Cx30 contributes to their differential anionic permeabilities
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Includes: Supplementary data
Journal Articles

Different fluorescent labels report distinct components of spHCN channel voltage sensor movement

Magdalena N. Wojciechowski, Chaseley E. McKenzie, Andrew Hung, Alibek Kuanyshbek, Ming S. Soh, Christopher A. Reid, Ian C. Forster
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (8): e202413559.
https://doi.org/10.1085/jgp.202413559
Published: 05 July 2024
View article titled, Different fluorescent labels report distinct components of spHCN channel voltage sensor movement
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Includes: Supplementary data
Journal Articles

Hydrophobic residues in S1 modulate enzymatic function and voltage sensing in voltage-sensing phosphatase

In Special Collection:
Molecular Insights into Membrane Protein Function
Vamseedhar Rayaprolu, Heini M. Miettinen, William D. Baker, Victoria C. Young, Matthew Fisher, Gwendolyn Mueller, William O. Rankin, John T. Kelley, William J. Ratzan, Lee Min Leong, Joshua A. Davisson, Bradley J. Baker, Susy C. Kohout
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (7): e202313467.
https://doi.org/10.1085/jgp.202313467
Published: 21 May 2024
View article titled, Hydrophobic residues in S1 modulate enzymatic function and voltage sensing in voltage-sensing phosphatase
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Includes: Supplementary data
Journal Articles

Tail length and E525K dilated cardiomyopathy mutant alter human β-cardiac myosin super-relaxed state

Sebastian Duno-Miranda, Shane R. Nelson, David V. Rasicci, Skylar M.L. Bodt, Joseph A. Cirilo, Jr, Duha Vang, Sivaraj Sivaramakrishnan, Christopher M. Yengo, David M. Warshaw
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (6): e202313522.
https://doi.org/10.1085/jgp.202313522
Published: 06 May 2024
View article titled, Tail length and E525K dilated cardiomyopathy mutant alter human β-cardiac myosin super-relaxed state
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Includes: Supplementary data
Journal Articles

Mutation in pore-helix modulates interplay between filter gate and Ba2+ block in a Kcv channel pore

Noel Tewes, Beatrice Kubitzki, Flandrit Bytyqi, Nikola Metko, Sebastian Mach, Gerhard Thiel, Oliver Rauh
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (5): e202313514.
https://doi.org/10.1085/jgp.202313514
Published: 23 April 2024
View article titled, Mutation in pore-helix modulates interplay between filter gate and Ba2+ block in a Kcv channel pore
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