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Journal Articles

Null method to estimate the maximal PA at subsaturating concentrations of agonist

Allison L. Germann, Spencer R. Pierce, Joe Henry Steinbach, Gustav Akk
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413644.
https://doi.org/10.1085/jgp.202413644
Published: 25 November 2024
View article titled, Null method to estimate the maximal P<sub>A</sub> at subsaturating concentrations of agonist
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Journal Articles

Mechanism of acid-sensing ion channel modulation by Hi1a

Kyle D. Berger, David M. MacLean
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202313519.
https://doi.org/10.1085/jgp.202313519
Published: 24 October 2024
View article titled, Mechanism of acid-sensing ion channel modulation by Hi1a
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Includes: Supplementary data
Journal Articles

ω-Grammotoxin-SIA inhibits voltage-gated Na+ channel currents

Rita de Cássia Collaço, Filip Van Petegem, Frank Bosmans
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2024) 156 (10): e202413563.
https://doi.org/10.1085/jgp.202413563
Published: 23 July 2024
View article titled, ω-Grammotoxin-SIA inhibits voltage-gated Na<sup>+</sup> channel currents
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Includes: Supplementary data
Journal Articles

Carboxyl-group compounds activate voltage-gated potassium channels via a distinct mechanism

Olle Rönnelid, Fredrik Elinder
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (7): e202313516.
https://doi.org/10.1085/jgp.202313516
Published: 04 June 2024
View article titled, Carboxyl-group compounds activate voltage-gated potassium channels via a distinct mechanism
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Journal Articles

Niclosamide potentiates TMEM16A and induces vasoconstriction

Pengfei Liang, Yui Chun S. Wan, Kuai Yu, H. Criss Hartzell, Huanghe Yang
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (7): e202313460.
https://doi.org/10.1085/jgp.202313460
Published: 30 May 2024
View article titled, Niclosamide potentiates TMEM16A and induces vasoconstriction
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Journal Articles

Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide–gated (HCN4) channels

In Special Collection:
Molecular Insights into Membrane Protein Function
Dana A. Page, Peter C. Ruben
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (6): e202313505.
https://doi.org/10.1085/jgp.202313505
Published: 23 April 2024
View article titled, Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide–gated (HCN4) channels
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Journal Articles

Honeybee CaV4 has distinct permeation, inactivation, and pharmacology from homologous NaV channels

In Special Collection:
Molecular Insights into Membrane Protein Function
Anaïs Bertaud, Thierry Cens, Alain Chavanieu, Sébastien Estaran, Matthieu Rousset, Lisa Soussi, Claudine Ménard, Akelsso Kadala, Claude Collet, Sébastien Dutertre, Patrick Bois, Pascal Gosselin-Badaroudine, Jean-Baptiste Thibaud, Julien Roussel, Michel Vignes, Mohamed Chahine, Pierre Charnet
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (5): e202313509.
https://doi.org/10.1085/jgp.202313509
Published: 01 April 2024
View article titled, Honeybee Ca<sub>V</sub>4 has distinct permeation, inactivation, and pharmacology from homologous Na<sub>V</sub> channels
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Journal Articles

Elucidating molecular mechanisms of protoxin-II state-specific binding to the human NaV1.7 channel

Khoa Ngo, Diego Lopez Mateos, Yanxiao Han, Kyle C. Rouen, Surl-Hee Ahn, Heike Wulff, Colleen E. Clancy, Vladimir Yarov-Yarovoy, Igor Vorobyov
Journal: Journal of General Physiology
J Gen Physiol (2023) 156 (2): e202313368.
https://doi.org/10.1085/jgp.202313368
Published: 21 December 2023
View article titled, Elucidating molecular mechanisms of protoxin-II state-specific binding to the human Na<sub>V</sub>1.7 channel
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Includes: Supplementary data
Journal Articles

Permeant cations modulate pore dynamics and gating of TRPV1 ion channels

Miriam García-Ávila, Javier Tello-Marmolejo, Tamara Rosenbaum, León D. Islas
Journal: Journal of General Physiology
J Gen Physiol (2023) 156 (1): e202313422.
https://doi.org/10.1085/jgp.202313422
Published: 06 December 2023
View article titled, Permeant cations modulate pore dynamics and gating of TRPV1 ion channels
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Journal Articles

Analogs of FTY720 inhibit TRPM7 but not S1PRs and exert multimodal anti-inflammatory effects

Gregory W. Busey, Mohan C. Manjegowda, Tao Huang, Wesley H. Iobst, Shardul S. Naphade, Joel A. Kennedy, Catherine A. Doyle, Philip V. Seegren, Kevin R. Lynch, Bimal N. Desai
Journal: Journal of General Physiology
J Gen Physiol (2023) 156 (1): e202313419.
https://doi.org/10.1085/jgp.202313419
Published: 09 November 2023
View article titled, Analogs of FTY720 inhibit TRPM7 but not S1PRs and exert multimodal anti-inflammatory effects
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Journal Articles

Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels

In Special Collection:
Molecular Insights into Membrane Protein Function
Denis B. Tikhonov, Boris S. Zhorov
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (11): e202313418.
https://doi.org/10.1085/jgp.202313418
Published: 20 September 2023
View article titled, Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels
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Journal Articles

Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6

Kafa Walweel, Nicole Beard, Dirk F. van Helden, Derek R. Laver
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (8): e202213277.
https://doi.org/10.1085/jgp.202213277
Published: 06 June 2023
View article titled, Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6
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Includes: Supplementary data
Journal Articles

BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca2+-bowl site

Guanxing Chen, Qin Li, Timothy I. Webb, Mark A. Hollywood, Jiusheng Yan
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (6): e202213237.
https://doi.org/10.1085/jgp.202213237
Published: 02 May 2023
View article titled, BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca<sup>2+</sup>-bowl site
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Includes: Supplementary data
Journal Articles

Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists

In Special Collection:
Physiology of Pain Detection and Processing Collection 2023
Nirvan Rouzbeh, Andrew R. Rau, Avery J. Benton, Feng Yi, Carly M. Anderson, Mia R. Johns, Loren Jensen, James S. Lotti, David C. Holley, Kasper B. Hansen
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (6): e202313340.
https://doi.org/10.1085/jgp.202313340
Published: 20 April 2023
View article titled, Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists
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Journal Articles

Probenecid affects muscle Ca2+ homeostasis and contraction independently from pannexin channel block

Francisco Jaque-Fernandez, Bruno Allard, Laloé Monteiro, Aude Lafoux, Corinne Huchet, Enrique Jaimovich, Christine Berthier, Vincent Jacquemond
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (4): e202213203.
https://doi.org/10.1085/jgp.202213203
Published: 23 February 2023
View article titled, Probenecid affects muscle Ca<sup>2+</sup> homeostasis and contraction independently from pannexin channel block
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Journal Articles

Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function

Thasin A. Peyear, Olaf S. Andersen
Journal: Journal of General Physiology
J Gen Physiol (2023) 155 (4): e202213247.
https://doi.org/10.1085/jgp.202213247
Published: 10 February 2023
View article titled, Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function
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Includes: Supplementary data
Journal Articles

Cm28, a scorpion toxin having a unique primary structure, inhibits KV1.2 and KV1.3 with high affinity

Muhammad Umair Naseem, Edson Carcamo-Noriega, José Beltrán-Vidal, Jesus Borrego, Tibor G. Szanto, Fernando Z. Zamudio, Gustavo Delgado-Prudencio, Lourival D. Possani, Gyorgy Panyi
Journal: Journal of General Physiology
J Gen Physiol (2022) 154 (8): e202213146.
https://doi.org/10.1085/jgp.202213146
Published: 14 June 2022
View article titled, Cm28, a scorpion toxin having a unique primary structure, inhibits K<sub>V</sub>1.2 and K<sub>V</sub>1.3 with high affinity
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Journal Articles

Probing function in ligand-gated ion channels without measuring ion transport

In Special Collection:
Biophysics 2023
Nicole E. Godellas, Claudio Grosman
Journal: Journal of General Physiology
J Gen Physiol (2022) 154 (6): e202213082.
https://doi.org/10.1085/jgp.202213082
Published: 25 May 2022
View article titled, Probing function in ligand-gated ion channels without measuring ion transport
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Journal Articles

Mechanism of use-dependent Kv2 channel inhibition by RY785

Matthew James Marquis, Jon T. Sack
Journal: Journal of General Physiology
J Gen Physiol (2022) 154 (6): e202112981.
https://doi.org/10.1085/jgp.202112981
Published: 18 April 2022
View article titled, Mechanism of use-dependent Kv2 channel inhibition by RY785
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Journal Articles

The action of Con-ikot-ikot toxin on single AMPA-type glutamate receptors

In Special Collection:
Neuroscience Collection 2022
Jelena Baranovic, Sebastian Braunbeck, Nikolai Zaki, Sonja Minniberger, Miriam Chebli, Andrew J.R. Plested
Journal: Journal of General Physiology
J Gen Physiol (2022) 154 (5): e202112912.
https://doi.org/10.1085/jgp.202112912
Published: 04 April 2022
View article titled, The action of Con-ikot-ikot toxin on single AMPA-type glutamate receptors
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