Molecular Pharmacology
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Journal Articles

Equivalent gain-of-function variants in KCNK3 and KCNK9 and their contribution to distinct TASK K2P channelopathies

Kate M. Crowther, Thibault R.H. Jouen-Tachoire, Peter Proks, Peter Rory Hall, Emma L. Veale, Janina Sörmann, Karin E.J. Rödström, Thomas Müller, Saskia B. Wortmann, Nina Barisic, Natalie Hauser, Vincenzo Salpietro, RaeLynn Forsyth, Linford Williams, Nora Derrabi, Carlos A. Bacino, Jill A. Rosenfeld, Henry Houlden, Simon Newstead, Caroline F. Wright, James Fasham, Alistair A. Mathie, Reza Maroofian, Stephen J. Tucker
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (5): e202613989.
https://doi.org/10.1085/jgp.202613989
Published: 06 August 2026
View article titled, Equivalent gain-of-function variants in KCNK3 and KCNK9 and their contribution to distinct TASK K2P channelopathies
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Includes: Supplementary data
Journal Articles

Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV

In Special Collection:
Voltage-Gated Na Channels 2026
Maxime Lammens, Jolien De Waele, Alain J. Labro, Filip Van Petegem, Frank Bosmans
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels 2026
J Gen Physiol (2026) 158 (5): e202614018.
https://doi.org/10.1085/jgp.202614018
Published: 29 June 2026
View article titled, Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV
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Journal Articles

Mechanistic insights into DCPIB inhibition of VRAC: Electrostatic control and binding plasticity

Héctor Gaitán-Peñas, Salomé Llabrés, Marina Pedrola, Marc González-Subías, Jordi Juárez-Jiménez, Michael Pusch, Rodolfo Lavilla, Raúl Estévez
Journal: Journal of General Physiology
Series: Chloride Channels and Transporters
J Gen Physiol (2026) 158 (5): e202513953.
https://doi.org/10.1085/jgp.202513953
Published: 25 June 2026
View article titled, Mechanistic insights into DCPIB inhibition of VRAC: Electrostatic control and binding plasticity
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Includes: Supplementary data
Journal Articles

A kinetic trap mechanism underlies hHv1 inhibition by NZ-58

Adam Feher, Geraldo Jorge Domingos, Martina Piga, Tihomir Tomašič, Nace Zidar, Zoltan Varga
Journal: Journal of General Physiology
Series: Ion Channels in Health and Disease
J Gen Physiol (2026) 158 (4): e202513945.
https://doi.org/10.1085/jgp.202513945
Published: 28 May 2026
View article titled, A kinetic trap mechanism underlies hHv1 inhibition by NZ-58
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Includes: Supplementary data
Journal Articles

Putative RNA editing of a nicotinic receptor increases acetylcholine sensitivity

Cecilia M. Borghese, Ying Lu, Edward J. Bertaccini, Harold H. Zakon
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (3): e202413677.
https://doi.org/10.1085/jgp.202413677
Published: 23 February 2026
View article titled, Putative RNA editing of a nicotinic receptor increases acetylcholine sensitivity
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Journal Articles

Inhibition of CaV1.4 channels by CaV3 channel antagonists ML218 and Z944

Jinglang Sun, Juan de la Rosa Vázquez, Adriana Hernández-González, Vladimir Yarov-Yarovoy, Amy Lee
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (2): e202513879.
https://doi.org/10.1085/jgp.202513879
Published: 05 January 2026
View article titled, Inhibition of CaV1.4 channels by CaV3 channel antagonists ML218 and Z944
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Includes: Supplementary data
Journal Articles

A critical residue mediates proper assembly and gating of GIRK2 channels

Ha Nguyen, Jonathan Mount, Keino Hutchinson, Yihan Zhao, Yulin Zhao, Ian W. Glaaser, Peng Yuan, Avner Schlessinger, Paul A. Slesinger
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513817.
https://doi.org/10.1085/jgp.202513817
Published: 19 December 2025
View article titled, A critical residue mediates proper assembly and gating of GIRK2 channels
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Includes: Supplementary data
Journal Articles

Novel binding mode for negative allosteric NMDA receptor modulators

James S. Lotti, Jed T. Syrenne, Avery J. Benton, Ahmad Al-Mousawi, Lauren E. Cornelison, Christopher J. Trolinder, Feng Yi, Zhucheng Zhang, Cindee K. Yates-Hansen, Levi J. McClelland, James Bosco, Andrew R. Rau, Rasmus P. Clausen, Kasper B. Hansen
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513872.
https://doi.org/10.1085/jgp.202513872
Published: 03 December 2025
View article titled, Novel binding mode for negative allosteric NMDA receptor modulators
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Includes: Supplementary data
Journal Articles

Cortical spreading depression dynamics are altered by topical D2 receptor ligands

Sonia Carolina Guerrero Prieto, Michael Cabrera Baez, Rubem Carlos Araújo Guedes
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (6): e202513843.
https://doi.org/10.1085/jgp.202513843
Published: 07 October 2025
View article titled, Cortical spreading depression dynamics are altered by topical D2 receptor ligands
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Journal Articles

Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826

In Special Collection:
Neuroscience Collection 2025
Sooyeon Jo, Akie Fujita, Tomás Osorno, Robert G. Stewart, Patric M. Vaelli, Bruce P. Bean
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (4): e202413719.
https://doi.org/10.1085/jgp.202413719
Published: 26 March 2025
View article titled, Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826
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Journal Articles

ALLIN: A tool for annotation of a protein alignment combined with structural visualization

Alessandra Picollo, Michael Pusch
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (2): e202413635.
https://doi.org/10.1085/jgp.202413635
Published: 31 December 2024
View article titled, ALLIN: A tool for annotation of a protein alignment combined with structural visualization
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Journal Articles

Null method to estimate the maximal PA at subsaturating concentrations of agonist

Allison L. Germann, Spencer R. Pierce, Joe Henry Steinbach, Gustav Akk
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413644.
https://doi.org/10.1085/jgp.202413644
Published: 25 November 2024
View article titled, Null method to estimate the maximal PA at subsaturating concentrations of agonist
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Journal Articles

Mechanism of acid-sensing ion channel modulation by Hi1a

In Special Collection:
JGP Highlights Collection 2025
Kyle D. Berger, David M. MacLean
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202313519.
https://doi.org/10.1085/jgp.202313519
Published: 24 October 2024
View article titled, Mechanism of acid-sensing ion channel modulation by Hi1a
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Includes: Supplementary data
Journal Articles

ω-Grammotoxin-SIA inhibits voltage-gated Na+ channel currents

Rita de Cássia Collaço, Filip Van Petegem, Frank Bosmans
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2024) 156 (10): e202413563.
https://doi.org/10.1085/jgp.202413563
Published: 23 July 2024
View article titled, ω-Grammotoxin-SIA inhibits voltage-gated Na+ channel currents
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Includes: Supplementary data
Journal Articles

Carboxyl-group compounds activate voltage-gated potassium channels via a distinct mechanism

Olle Rönnelid, Fredrik Elinder
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (7): e202313516.
https://doi.org/10.1085/jgp.202313516
Published: 04 June 2024
View article titled, Carboxyl-group compounds activate voltage-gated potassium channels via a distinct mechanism
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Journal Articles

Niclosamide potentiates TMEM16A and induces vasoconstriction

Pengfei Liang, Yui Chun S. Wan, Kuai Yu, H. Criss Hartzell, Huanghe Yang
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (7): e202313460.
https://doi.org/10.1085/jgp.202313460
Published: 30 May 2024
View article titled, Niclosamide potentiates TMEM16A and induces vasoconstriction
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Journal Articles

Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide–gated (HCN4) channels

In Special Collection:
Molecular Insights into Membrane Protein Function
Dana A. Page, Peter C. Ruben
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (6): e202313505.
https://doi.org/10.1085/jgp.202313505
Published: 23 April 2024
View article titled, Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide–gated (HCN4) channels
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Journal Articles

Honeybee CaV4 has distinct permeation, inactivation, and pharmacology from homologous NaV channels

In Special Collection:
Molecular Insights into Membrane Protein Function
Anaïs Bertaud, Thierry Cens, Alain Chavanieu, Sébastien Estaran, Matthieu Rousset, Lisa Soussi, Claudine Ménard, Akelsso Kadala, Claude Collet, Sébastien Dutertre, Patrick Bois, Pascal Gosselin-Badaroudine, Jean-Baptiste Thibaud, Julien Roussel, Michel Vignes, Mohamed Chahine, Pierre Charnet
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (5): e202313509.
https://doi.org/10.1085/jgp.202313509
Published: 01 April 2024
View article titled, Honeybee CaV4 has distinct permeation, inactivation, and pharmacology from homologous NaV channels
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Journal Articles

Elucidating molecular mechanisms of protoxin-II state-specific binding to the human NaV1.7 channel

Khoa Ngo, Diego Lopez Mateos, Yanxiao Han, Kyle C. Rouen, Surl-Hee Ahn, Heike Wulff, Colleen E. Clancy, Vladimir Yarov-Yarovoy, Igor Vorobyov
Journal: Journal of General Physiology
J Gen Physiol (2023) 156 (2): e202313368.
https://doi.org/10.1085/jgp.202313368
Published: 21 December 2023
View article titled, Elucidating molecular mechanisms of protoxin-II state-specific binding to the human NaV1.7 channel
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Includes: Supplementary data
Journal Articles

Permeant cations modulate pore dynamics and gating of TRPV1 ion channels

Miriam García-Ávila, Javier Tello-Marmolejo, Tamara Rosenbaum, León D. Islas
Journal: Journal of General Physiology
J Gen Physiol (2023) 156 (1): e202313422.
https://doi.org/10.1085/jgp.202313422
Published: 06 December 2023
View article titled, Permeant cations modulate pore dynamics and gating of TRPV1 ion channels
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