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Journal Articles

Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions

Sofia F. Nazarova, Vadim A. Alekhin, Vladislav V. Pavlov, Yury S. Semenov, Siarhei M. Bukhalovich, Fedor M. Tsybrov, Andrey O. Bogorodskiy, Diana F. Bagaeva, Olga V. Moiseeva, Anastasiia D. Vlasova, Anatolii E. Mikhailov, Yayu Wang, Andrey V. Rogachev, Semen V. Nesterov, Valentin I. Borshchevskiy, Chunlei Cang, Piotr D. Bregestovski, Valentin I. Gordeliy, Nikolay S. Ilyinsky
Journal: Journal of General Physiology
Series: Molecular evolution in the membrane
J Gen Physiol (2026) 158 (4): e202413745.
https://doi.org/10.1085/jgp.202413745
Published: 18 June 2026
View article titled, Stressed lysosome: A theoretical model of lysosomal pH regulation applied to stress conditions
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Includes: Supplementary data
Journal Articles

Model of ocular surface ion and water transport predicts efficacy of dry eye therapeutics

Varun Verma, Ethan S. Lindgren, Marc H. Levin, Onur Cil, Lukmanee Tradtrantip, Rongshan Yan, Neel D. Pasricha, Alan S. Verkman
Journal: Journal of General Physiology
Series: Chloride Channels and Transporters
J Gen Physiol (2026) 158 (4): e202513958.
https://doi.org/10.1085/jgp.202513958
Published: 22 May 2026
View article titled, Model of ocular surface ion and water transport predicts efficacy of dry eye therapeutics
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Journal Articles

Extrinsic inputs underscore heterogeneities of ELL pyramidal cell neural activity in awake, behaving weakly electric fish

Amin Akhshi, Myriah Haggard, Mariana M. Marquez, Saeed Farjami, Maurice J. Chacron, Anmar Khadra
Journal: Journal of General Physiology
J Gen Physiol (2026) 158 (4): e202513841.
https://doi.org/10.1085/jgp.202513841
Published: 29 April 2026
View article titled, Extrinsic inputs underscore heterogeneities of ELL pyramidal cell neural activity in awake, behaving weakly electric fish
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Includes: Supplementary data
Journal Articles

Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2

Diego Lopez-Mateos, Kush Narang, Vladimir Yarov-Yarovoy
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels 2026
J Gen Physiol (2025) 158 (2): e202413705.
https://doi.org/10.1085/jgp.202413705
Published: 18 December 2025
View article titled, Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2
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Includes: Supplementary data
Journal Articles

Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?

Eduardo Rios
Journal: Journal of General Physiology
J Gen Physiol (2025) 158 (1): e202513877.
https://doi.org/10.1085/jgp.202513877
Published: 17 December 2025
View article titled, Allosteric coupling of RyR calcium channels: Is it relevant to the [patho]physiology of heart and muscle?
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Journal Articles

Cortical spreading depression dynamics are altered by topical D2 receptor ligands

Sonia Carolina Guerrero Prieto, Michael Cabrera Baez, Rubem Carlos Araújo Guedes
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (6): e202513843.
https://doi.org/10.1085/jgp.202513843
Published: 07 October 2025
View article titled, Cortical spreading depression dynamics are altered by topical D2 receptor ligands
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Journal Articles

GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle

Bin Sun, Alec Loftus, Brandon Beh Goh Beh, Aalaythia Hepburn, Jonathan A. Kirk, Peter M. Kekenes-Huskey
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (5): e202413737.
https://doi.org/10.1085/jgp.202413737
Published: 26 August 2025
View article titled, GSK3β-driven phosphorylation of ABLIM1 regulates its interactions with titin cardiac muscle
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Includes: Supplementary data
Journal Articles

Exploring a peripheral PIP2-binding site and its role in the alternative regulation of the TRP channel superfamily

L. Gonzalo Espinoza-Arcos, Mariela González-Avendaño, Matías Zuñiga-Bustos, Ricardo A. Zamora, Ariela Vergara-Jaque, Horacio Poblete
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (6): e202413574.
https://doi.org/10.1085/jgp.202413574
Published: 22 August 2025
View article titled, Exploring a peripheral PIP2-binding site and its role in the alternative regulation of the TRP channel superfamily
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Includes: Supplementary data
Journal Articles

Variability in reported midpoints of (in)activation of cardiac INa

Michael Clerx, Paul G.A. Volders, Gary R. Mirams
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (5): e202413621.
https://doi.org/10.1085/jgp.202413621
Published: 16 July 2025
View article titled, Variability in reported midpoints of (in)activation of cardiac INa
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Includes: Supplementary data
Journal Articles

Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44

David Gong, Jennifer L. Orthmann-Murphy, Deepak Kumar, Gabriel D. Dungan, Ayman W. El-Hattab, Nicoline Schiess, Yun L. Luo, Mona M. Freidin, Charles K. Abrams
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (4): e202413617.
https://doi.org/10.1085/jgp.202413617
Published: 10 June 2025
View article titled, Molecular dynamics simulation of GJC2 mutants reveal pathogenic mechanisms of PMLD1 and SPG44
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Includes: Supplementary data
Journal Articles

Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels

Benjamin T. Simonson, Zhaoyang Jiang, Joseph F. Ryan, Timothy Jegla
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413740.
https://doi.org/10.1085/jgp.202413740
Published: 18 March 2025
View article titled, Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels
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Includes: Supplementary data
Journal Articles

Novel Ca2+ wave mechanisms in cardiac myocytes revealed by multiscale Ca2+ release model

Morris Vysma, James S. Welsh, Derek R. Laver
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413543.
https://doi.org/10.1085/jgp.202413543
Published: 06 March 2025
View article titled, Novel Ca2+ wave mechanisms in cardiac myocytes revealed by multiscale Ca2+ release model
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Includes: Supplementary data
Journal Articles

The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses

In Special Collection:
Neuroscience Collection 2025
Wallace B. Thoreson, Thomas M. Bartol, Nicholas H. Conoan, Jeffrey S. Diamond
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413746.
https://doi.org/10.1085/jgp.202413746
Published: 28 February 2025
View article titled, The architecture of invaginating rod synapses slows glutamate diffusion and shapes synaptic responses
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Journal Articles

In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel

Alp Tegin Şahin, Ulrich Zachariae
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202313506.
https://doi.org/10.1085/jgp.202313506
Published: 21 February 2025
View article titled, In silico characterization of the gating and selectivity mechanism of the human TPC2 cation channel
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Includes: Supplementary data
Journal Articles

Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease

Maya Noureddine, Halina Mikolajek, Neil V. Morgan, Chris Denning, Siobhan Loughna, Katja Gehmlich, Fiyaz Mohammed
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (2): e202413684.
https://doi.org/10.1085/jgp.202413684
Published: 07 February 2025
View article titled, Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease
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Includes: Supplementary data
Journal Articles

Mechanisms underlying the distinct K+ dependencies of periodic paralysis

Brent D. Foy, Chris Dupont, Phillip V. Walker, II, Kirsten Denman, Kathrin L. Engisch, Mark M. Rich
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413610.
https://doi.org/10.1085/jgp.202413610
Published: 04 February 2025
View article titled, Mechanisms underlying the distinct K+ dependencies of periodic paralysis
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Includes: Supplementary data
Journal Articles

Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium

Tuan A. Phan, Daniel P. Fitzsimons
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (2): e202413582.
https://doi.org/10.1085/jgp.202413582
Published: 27 January 2025
View article titled, Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium
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Includes: Supplementary data
Journal Articles

The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels

Eslam Elhanafy, Amin Akbari Ahangar, Rebecca Roth, Tamer M. Gamal El-Din, John R. Bankston, Jing Li
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413669.
https://doi.org/10.1085/jgp.202413669
Published: 17 January 2025
View article titled, The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels
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Includes: Supplementary data
Journal Articles

Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore

Elaine Tao, Ben Corry
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413658.
https://doi.org/10.1085/jgp.202413658
Published: 07 January 2025
View article titled, Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore
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Journal Articles

Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites

In Special Collection:
JGP Highlights Collection 2025
Christopher A. Beaudoin, Manas Kohli, Samantha C. Salvage, Hengrui Liu, Samuel J. Arundel, Samir W. Hamaia, Ming Lei, Christopher L.-H. Huang, Antony P. Jackson
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2024) 157 (1): e202413609.
https://doi.org/10.1085/jgp.202413609
Published: 16 December 2024
View article titled, Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites
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