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Journal Articles

Obscurin deficiency leads to compensated dilated cardiomyopathy and increased arrhythmias

Josè Manuel Pioner, Enrico Pierantozzi, Raffaele Coppini, Egidio Maria Rubino, Valentina Biasci, Giulia Vitale, Annunziatina Laurino, Lorenzo Santini, Marina Scardigli, Davide Randazzo, Camilla Olianti, Matteo Serano, Daniela Rossi, Chiara Tesi, Elisabetta Cerbai, Stephan Lange, Carlo Reggiani, Leonardo Sacconi, Corrado Poggesi, Cecilia Ferrantini, Vincenzo Sorrentino
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (4): e202413696.
https://doi.org/10.1085/jgp.202413696
Published: 14 May 2025
View articletitled, Obscurin deficiency leads to compensated dilated cardiomyopathy and increased arrhythmias
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Includes: Supplementary data
Journal Articles

Prediction and biological significance of small changes in binding of leiomodin to tropomyosin

Eduardo Sánchez Díaz, Brayan Osegueda, Svetlana Minakhina, Nickolas Starks, Stefanie Novak, Dmitri Tolkatchev, Carol C. Gregorio, Alla S. Kostyukova, Garry E. Smith, Jr
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (4): e202413641.
https://doi.org/10.1085/jgp.202413641
Published: 24 April 2025
View articletitled, Prediction and biological significance of small changes in binding of leiomodin to tropomyosin
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Includes: Supplementary data
Journal Articles

Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes

Kerry S. McDonald, Theodore J. Kalogeris, Adam B. Veteto, Daniel J. Davis, Laurin M. Hanft
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (3): e202413678.
https://doi.org/10.1085/jgp.202413678
Published: 24 March 2025
View articletitled, Myosin binding protein-C modulates loaded sarcomere shortening in rodent permeabilized cardiac myocytes
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Journal Articles

Marfan syndrome cardiomyocytes show excess of titin isoform N2BA and extended sarcomeric M-band

Dalma Kellermayer, Cristina M. Șulea, Hedvig Tordai, Kálmán Benke, Miklós Pólos, Bence Ágg, Roland Stengl, Máté Csonka, Tamás Radovits, Béla Merkely, Zoltán Szabolcs, Miklós Kellermayer, Balázs Kiss
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (3): e202413690.
https://doi.org/10.1085/jgp.202413690
Published: 10 March 2025
View articletitled, Marfan syndrome cardiomyocytes show excess of titin isoform N2BA and extended sarcomeric M-band
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Includes: Supplementary data
Journal Articles

Novel Ca2+ wave mechanisms in cardiac myocytes revealed by multiscale Ca2+ release model

Morris Vysma, James S. Welsh, Derek R. Laver
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (3): e202413543.
https://doi.org/10.1085/jgp.202413543
Published: 06 March 2025
View articletitled, Novel Ca2+ wave mechanisms in cardiac myocytes revealed by multiscale Ca2+ release model
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Includes: Supplementary data
Journal Articles

Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease

Maya Noureddine, Halina Mikolajek, Neil V. Morgan, Chris Denning, Siobhan Loughna, Katja Gehmlich, Fiyaz Mohammed
Journal: Journal of General Physiology
Series: Contractile Function
J Gen Physiol (2025) 157 (2): e202413684.
https://doi.org/10.1085/jgp.202413684
Published: 07 February 2025
View articletitled, Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease
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Includes: Supplementary data
Journal Articles

Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium

Tuan A. Phan, Daniel P. Fitzsimons
Journal: Journal of General Physiology
J Gen Physiol (2025) 157 (2): e202413582.
https://doi.org/10.1085/jgp.202413582
Published: 27 January 2025
View articletitled, Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium
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Includes: Supplementary data
Journal Articles

How does mitochondrial Ca2+ change during ischemia and reperfusion? Implications for activation of the permeability transition pore

Elizabeth Murphy, David A. Eisner
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202313520.
https://doi.org/10.1085/jgp.202313520
Published: 19 December 2024
View articletitled, How does mitochondrial Ca2+ change during ischemia and reperfusion? Implications for activation of the permeability transition pore
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Journal Articles

Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites

Christopher A. Beaudoin, Manas Kohli, Samantha C. Salvage, Hengrui Liu, Samuel J. Arundel, Samir W. Hamaia, Ming Lei, Christopher L.-H. Huang, Antony P. Jackson
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2024) 157 (1): e202413609.
https://doi.org/10.1085/jgp.202413609
Published: 16 December 2024
View articletitled, Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites
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Journal Articles

Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency

Amy D. Hanna, Ting Chang, Kevin S. Ho, Rachel Sue Zhen Yee, William Cameron Walker, Nadia Agha, Chih-Wei Hsu, Sung Yun Jung, Mary E. Dickinson, Md. Abul Hassan Samee, Christopher S. Ward, Chang Seok Lee, George G. Rodney, Susan L. Hamilton
Journal: Journal of General Physiology
J Gen Physiol (2024) 157 (1): e202413583.
https://doi.org/10.1085/jgp.202413583
Published: 11 December 2024
View articletitled, Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency
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Includes: Supplementary data
Journal Articles

Stochastic force generation in an isometric binary mechanical system

Vidya Murthy, Josh E. Baker
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202313493.
https://doi.org/10.1085/jgp.202313493
Published: 19 November 2024
View articletitled, Stochastic force generation in an isometric binary mechanical system
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Includes: Supplementary data
Journal Articles

Exercise training may reduce fragmented mitochondria in the ischemic-reperfused heart through DRP1

Mathilde Dubois, Florian Pallot, Maxime Gouin-Gravezat, Doria Boulghobra, Florence Coste, Guillaume Walther, Gregory Meyer, Isabelle Bornard, Cyril Reboul
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (12): e202313485.
https://doi.org/10.1085/jgp.202313485
Published: 07 November 2024
View articletitled, Exercise training may reduce fragmented mitochondria in the ischemic-reperfused heart through DRP1
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Includes: Supplementary data
Journal Articles

Calcium has a direct effect on thick filament activation in porcine myocardium

Saffie Mohran, Timothy S. McMillen, Christian Mandrycky, An-Yue Tu, Kristina B. Kooiker, Wenjing Qian, Stephanie Neys, Brayan Osegueda, Farid Moussavi-Harami, Thomas C. Irving, Michael Regnier, Weikang Ma
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (11): e202413545.
https://doi.org/10.1085/jgp.202413545
Published: 20 September 2024
View articletitled, Calcium has a direct effect on thick filament activation in porcine myocardium
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Journal Articles

Mechanisms of a novel regulatory light chain–dependent cardiac myosin inhibitor

Kristina Kooiker, Qing-Fen Gan, Ming Yu, Na Sa, Saffie Mohran, Yuanhua Cheng, Galina Flint, Stephanie Neys, Chengqian Gao, Devin Nissen, Tim McMillen, Anthony Asencio, Weikang Ma, Thomas C. Irving, Farid Moussavi-Harami, Michael Regnier
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (10): e202313503.
https://doi.org/10.1085/jgp.202313503
Published: 31 July 2024
View articletitled, Mechanisms of a novel regulatory light chain–dependent cardiac myosin inhibitor
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Includes: Supplementary data
Journal Articles

The C-terminus of Rad is required for membrane localization and L-type calcium channel regulation

Garrett Elmore, Brooke M. Ahern, Nicholas M. McVay, Kyle W. Barker, Sarisha S. Lohano, Nemat Ali, Andrea Sebastian, Douglas A. Andres, Jonathan Satin, Bryana M. Levitan
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (9): e202313518.
https://doi.org/10.1085/jgp.202313518
Published: 11 July 2024
View articletitled, The C-terminus of Rad is required for membrane localization and L-type calcium channel regulation
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Includes: Supplementary data
Journal Articles

Tail length and E525K dilated cardiomyopathy mutant alter human β-cardiac myosin super-relaxed state

Sebastian Duno-Miranda, Shane R. Nelson, David V. Rasicci, Skylar M.L. Bodt, Joseph A. Cirilo, Jr, Duha Vang, Sivaraj Sivaramakrishnan, Christopher M. Yengo, David M. Warshaw
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (6): e202313522.
https://doi.org/10.1085/jgp.202313522
Published: 06 May 2024
View articletitled, Tail length and E525K dilated cardiomyopathy mutant alter human β-cardiac myosin super-relaxed state
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Includes: Supplementary data
Journal Articles

Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide–gated (HCN4) channels

In Special Collection:
Molecular Insights into Membrane Protein Function
Dana A. Page, Peter C. Ruben
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (6): e202313505.
https://doi.org/10.1085/jgp.202313505
Published: 23 April 2024
View articletitled, Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide–gated (HCN4) channels
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Journal Articles

Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin

Michael J. Rynkiewicz, Matthew C. Childers, Olga E. Karpicheva, Michael Regnier, Michael A. Geeves, William Lehman
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (5): e202413538.
https://doi.org/10.1085/jgp.202413538
Published: 12 April 2024
View articletitled, Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin
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Includes: Supplementary data
Journal Articles

Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers

Parisa Asghari, David R.L. Scriven, Saba Shahrasebi, Hector H. Valdivia, Katherina M. Alsina, Carmen R. Valdivia, J. Alberto Navarro-Garcia, Xander H.T. Wehrens, Edwin D.W. Moore
Journal: Journal of General Physiology
Series: Excitation–Contraction Coupling
J Gen Physiol (2024) 156 (4): e202213108.
https://doi.org/10.1085/jgp.202213108
Published: 22 February 2024
View articletitled, Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers
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Includes: Supplementary data
Journal Articles

Persistent PKA activation redistributes NaV1.5 to the cell surface of adult rat ventricular myocytes

Tytus Bernas, John Seo, Zachary T. Wilson, Bi-hua Tan, Isabelle Deschenes, Christiane Carter, Jinze Liu, Gea-Ny Tseng
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (2): e202313436.
https://doi.org/10.1085/jgp.202313436
Published: 16 January 2024
View articletitled, Persistent PKA activation redistributes NaV1.5 to the cell surface of adult rat ventricular myocytes
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Includes: Supplementary data