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Journal Articles

Calcium has a direct effect on thick filament activation in porcine myocardium

Saffie Mohran, Timothy S. McMillen, Christian Mandrycky, An-Yue Tu, Kristina B. Kooiker, Wenjing Qian, Stephanie Neys, Brayan Osegueda, Farid Moussavi-Harami, Thomas C. Irving, Michael Regnier, Weikang Ma
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (11): e202413545.
https://doi.org/10.1085/jgp.202413545
Published: 20 September 2024
View article titled, Calcium has a direct effect on thick filament activation in porcine myocardium
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Journal Articles

Mechanisms of a novel regulatory light chain–dependent cardiac myosin inhibitor

Kristina Kooiker, Qing-Fen Gan, Ming Yu, Na Sa, Saffie Mohran, Yuanhua Cheng, Galina Flint, Stephanie Neys, Chengqian Gao, Devin Nissen, Tim McMillen, Anthony Asencio, Weikang Ma, Thomas C. Irving, Farid Moussavi-Harami, Michael Regnier
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (10): e202313503.
https://doi.org/10.1085/jgp.202313503
Published: 31 July 2024
View article titled, Mechanisms of a novel regulatory light chain–dependent cardiac myosin inhibitor
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Includes: Supplementary data
Journal Articles

The C-terminus of Rad is required for membrane localization and L-type calcium channel regulation

Garrett Elmore, Brooke M. Ahern, Nicholas M. McVay, Kyle W. Barker, Sarisha S. Lohano, Nemat Ali, Andrea Sebastian, Douglas A. Andres, Jonathan Satin, Bryana M. Levitan
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (9): e202313518.
https://doi.org/10.1085/jgp.202313518
Published: 11 July 2024
View article titled, The C-terminus of Rad is required for membrane localization and L-type calcium channel regulation
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Includes: Supplementary data
Journal Articles

Tail length and E525K dilated cardiomyopathy mutant alter human β-cardiac myosin super-relaxed state

Sebastian Duno-Miranda, Shane R. Nelson, David V. Rasicci, Skylar M.L. Bodt, Joseph A. Cirilo, Jr, Duha Vang, Sivaraj Sivaramakrishnan, Christopher M. Yengo, David M. Warshaw
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (6): e202313522.
https://doi.org/10.1085/jgp.202313522
Published: 06 May 2024
View article titled, Tail length and E525K dilated cardiomyopathy mutant alter human β-cardiac myosin super-relaxed state
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Includes: Supplementary data
Journal Articles

Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide–gated (HCN4) channels

In Special Collection:
Molecular Insights into Membrane Protein Function
Dana A. Page, Peter C. Ruben
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (6): e202313505.
https://doi.org/10.1085/jgp.202313505
Published: 23 April 2024
View article titled, Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide–gated (HCN4) channels
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Journal Articles

Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin

Michael J. Rynkiewicz, Matthew C. Childers, Olga E. Karpicheva, Michael Regnier, Michael A. Geeves, William Lehman
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (5): e202413538.
https://doi.org/10.1085/jgp.202413538
Published: 12 April 2024
View article titled, Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin
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Includes: Supplementary data
Journal Articles

Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers

Parisa Asghari, David R.L. Scriven, Saba Shahrasebi, Hector H. Valdivia, Katherina M. Alsina, Carmen R. Valdivia, J. Alberto Navarro-Garcia, Xander H.T. Wehrens, Edwin D.W. Moore
Journal: Journal of General Physiology
Series: Excitation–Contraction Coupling
J Gen Physiol (2024) 156 (4): e202213108.
https://doi.org/10.1085/jgp.202213108
Published: 22 February 2024
View article titled, Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers
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Includes: Supplementary data
Journal Articles

Persistent PKA activation redistributes NaV1.5 to the cell surface of adult rat ventricular myocytes

Tytus Bernas, John Seo, Zachary T. Wilson, Bi-hua Tan, Isabelle Deschenes, Christiane Carter, Jinze Liu, Gea-Ny Tseng
Journal: Journal of General Physiology
J Gen Physiol (2024) 156 (2): e202313436.
https://doi.org/10.1085/jgp.202313436
Published: 16 January 2024
View article titled, Persistent PKA activation redistributes Na<sub>V</sub>1.5 to the cell surface of adult rat ventricular myocytes
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Includes: Supplementary data