Issues

Using a combined biophysical and computational approaches, we determined how morphological, intrinsic, and extrinsic factors shape spiking activity in vivo. The computational model was fitted to spiking experimental data, and the variations in the resulting parameters were used to predict the altered spiking activity. Our methodology is likely applicable to other systems and species.

This is a Review that covers the main advances in our understanding of fast sodium channel inactivation since the original work of Hodgkin and Huxley to the present era of structural biology.