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ON THE COVER
Metabolomic heat map displays surging levels of circulating lipids in postprandial Burmese python plasma. The dramatically higher level of lipids promotes beneficial cardiac growth. Lipid content was measured at three different states: fasted, 1 d post fed, and 3 d post fed. Image © Magida et al., 2022. See http://doi.org/10.1085/jgp.202113008. - PDF Icon PDF LinkTable of Contents
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Research News
Gap junctions and hemichannels keep the RPE connected
JGP study shows that the electrical properties of the retinal pigment epithelium are influenced by connexin-based gap junctions and hemichannels.
Commentary
Why are you talking with snakes? To get new evolutionary insights in cardiac electrophysiology!
Brette, Le Guennec, and Thireau discuss recent findings on evolutionary cardiac electrophysiology.
Articles
Gap junctions and connexin hemichannels both contribute to the electrical properties of retinal pigment epithelium
Cells in the retinal pigment epithelium are coupled through a dense network of Cx43-based gap junctions. Fadjukov et al. show that both gap junctions and Cx43 hemichannels make substantial contributions to the input resistance of these electrically active cells.
Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1
Dai uses FRET spectroscopy to show that the epilepsy-related potassium channels KCNQ2/3 are recruited to lipid-raft membrane domains to form a signaling complex with the Alzheimer’s disease–related protein BACE1, a process that is dependent on the palmitoylation of BACE1.
Burmese pythons exhibit a transient adaptation to nutrient overload that prevents liver damage
The Burmese python is an excellent model of extreme biology which exhibits dramatic metabolic responses following consumption of a large meal. Magida et al. uncover a novel adaptation of hepatic metabolism and cellular signaling in the postprandial Burmese python liver.
Communications
Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels
Rohaim and colleagues present a strategy to generate synthetic recombinant antibody fragments (sFabs) for structural biology and studies of K+ channels. These sFabs perform comparably to traditional Fabs but are easier to produce.
