-
Cover Image
Cover Image
ON THE COVER
Artistic reconstruction of a hippocampal pyramidal neuron transfected with biosensors for PtdIns (yellow), PtdIns(4)P (cyan), and PtdIns(4,5)P2 (magenta). Images were taken from different experiments and transformed to fit one cell. The kinetic analysis by de la Cruz et al. shows that neurons have a large PtdIns(4)P pool and synthesize PtdIns(4,5)P2 quickly. Image © de la Cruz et al., 2022. See http://doi.org/10.1085/jgp.202113001. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
Editorials
Research News
Troponin levels make a difference
JGP study reveals that lower troponin expression in the right ventricle underlies interventricular differences in excitation–contraction coupling.
Viewpoint
Extracellular mechanotransduction
Haller and Dudley highlight the force-sensing function of extracellular matrix and present a complementary mechanotransduction paradigm.
Articles
Lower troponin expression in the right ventricle of rats explains interventricular differences in E–C coupling
Right ventricular cardiomyocytes show shorter action potential and smaller shortening than left cardiomyocytes. Jeon et al. suggest that interventricular differences in excitation–contraction coupling are explained by lower expression of Ca2+-binding troponin in right ventricular cardiomyocytes.
Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation
Ovejero et al. show that cooling resting or relaxed rat heart muscle releases myosin motors from the helical folded conformation that inhibits actin interaction in physiological conditions.
Hippocampal neurons maintain a large PtdIns(4)P pool that results in faster PtdIns(4,5)P2 synthesis
Is phosphoinositide metabolism cell-type specific? By comparing the amount and rate of synthesis between hippocampal neurons, astrocytes, and the tsA201 cell line, de la Cruz et al. show that central neurons have a larger PtdIns(4)P pool and are faster at synthesizing PtdIns(4,5)P2.
