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Cover Image
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ON THE COVER
In this issue, Boukens and colleagues show that changes in ventricular repolarization in ball pythons occur during increasing body temperatures. Th is, however, is caused by increased tone of the sympathetic nervous system, indicating that repolarization in pythons and mammals is modulated by evolutionary conserved mechanisms involving catecholaminergic stimulation.. Image © Boukens et al., 2021. See http://doi.org/10.1085/jgp.202012761. - PDF Icon PDF LinkTable of Contents
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Research News
Catecholamines help snakes have a change of heart
JGP study on python snakes reveals that the regulation of ventricular repolarization by the sympathetic nervous system is evolutionarily conserved.
Commentary
Sarcomere length in the beating heart: Synchronicity is optional
Helmes and Palmer review research by Kobirumaki-Shimozawa et al.
Reviews
Functional and structural differences between skinned and intact muscle preparations
Lewalle et al. review differences in skinned and intact muscle preparations.
Articles
Catecholamines are key modulators of ventricular repolarization patterns in the ball python (Python regius)
Boukens and colleagues show that changes in ventricular repolarization in the ectothermic ball python are modulated by the sympathetic nervous system and not directly by changes in temperature. Their work shows that regulation of this process is conserved between pythons and mammals.
The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism
Riel et al. screened K+ channels of the K2P family for sensitivity to polyanionic lipids, such as PIP2 and oleoyl-CoA. They show that these lipids activate or inhibit individual channels with different affinity and establish them as potential effectors to regulate channel activity.
