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Mechanotransduction by Membrane Proteins

JGP study finds that the C. elegans orthologue of the PIEZO family is a mechanosensitive ion channel that regulates pharyngeal pumping and food sensation.


Super-relaxation is a state of myosin in which ATP turnover is very slow, conserving energy in relaxed muscle. This work discusses the molecular interactions underlying super- and hyper-relaxation and how these are modulated in normal muscle physiology and disease.


Mechanotransduction by Membrane Proteins
In Special Collection: Ion Channels Update 2022

Millet et al. show that the C. elegans orthologue of the PIEZO family, PEZO-1, is a mechanosensitive ion channel involved in food sensation and in regulating pharyngeal function in the nematode.

Morris et al. use a computational model of Pump-Leak/Donnan ion homeostasis to suggest that the Donnan dominated steady-state of skeletal muscle fibers underpins their longevity in the face of the structural and metabolic injuries incurred with Duchenne muscular dystrophy.

Chen et al. computationally model the open conformation of the hASIC1a channel to predict that mutations that eliminate channel selectivity cause a widening of the GAS belt. Their findings implicate the GAS belt diameter in channel kinetics and ion selectivity.

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