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Issues

Research News

JGP study suggests the anion exchanger AE1 operates via an elevator-like mechanism.

Commentary

Cannon reviews new evidence supporting a key role for anomalous inward currents in the etiology of hypokalemic periodic paralysis.

Review

Meissner reviews progress toward our understanding of ryanodine receptor structure and function.

Viewpoint

Arkhipova et al. caution that the limitations of structural models be taken into account when interpreting crystallographic data.

Article

VX-770 is a potentiator of the CFTR channel and an approved therapy for cystic fibrosis. Yeh et al. find that the apparent affinity of a new potentiator, GLPG1837, is state dependent and propose an allosteric modulation model to explain the potency and efficacy of CFTR potentiators.

Members of the pentameric ligand-gated ion channel family have been crystallized in different conformations, including one in which the transmembrane pore is surprisingly wide. Gonzalez-Gutierrez et al. show that the open-channel conformation of animal members is more similar to the models with narrow pores.

The V876E mutation in the muscle voltage-gated Ca2+ channel induces hypokalemic periodic paralysis. Fuster et al. show that the mutation generates strong resting inward leak Na+ currents even though it is not located in the voltage sensor segments.

Hypothesis

Anion exchanger 1 catalyzes the transmembrane antiport of chloride and bicarbonate ions through a mechanism that has remained unclear. By modeling its inward-facing state and comparing it with the known outward-facing form, Ficici et al. hypothesize that this transporter features an elevator-like mechanism.

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