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ISSN 0022-1295
EISSN 1540-7748
In this Issue

Generally Physiological



Perspectives on: The response to osmotic challenges

Research Articles

Decreasing the amplitude of the late component of the cardiac L-type Ca2+ channel current suppresses early afterdepolarizations, thereby decreasing the risk of arrhythmias.

Human cerebral arteries contain three Ca2+ channel subtypes with distinct physiological roles.

ADP-ribose-2′-phosphate acts as a direct agonist of TRPM2, whereas NAD, NAAD, and NAADP do not.

Phosphoinositides bind to a selective site in the proximal C-terminal region to regulate TRPV1.

Coarse-grained modeling and all-atom molecular dynamics simulation provide insight into the mechanism for heat activation of TRPV1 gating.

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