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Cover Image
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Cover picture: Candidate osmosensing mechanisms in plant cells include the activation of histidine kinases by osmotic imbalance across the plasma membrane (left), the opening of mechanosensitive ion channels in response to membrane tension or bending (middle), and the regulation of receptor-like kinases via extracellular domains capable of sensing changes in cell wall integrity (right). (See Perspective by Haswell and Verslues on osmosensing in plants, 389–394, in the Perspective Series on the cellular response to osmotic challenge.)
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Generally Physiological
Commentary
Perspective
Perspectives on: The response to osmotic challenges
Research Articles
Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations
Decreasing the amplitude of the late component of the cardiac L-type Ca2+ channel current suppresses early afterdepolarizations, thereby decreasing the risk of arrhythmias.
CaV1.2/CaV3.x channels mediate divergent vasomotor responses in human cerebral arteries
Human cerebral arteries contain three Ca2+ channel subtypes with distinct physiological roles.
Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2′-phosphate
ADP-ribose-2′-phosphate acts as a direct agonist of TRPM2, whereas NAD, NAAD, and NAADP do not.
Mechanism for phosphoinositide selectivity and activation of TRPV1 ion channels
Phosphoinositides bind to a selective site in the proximal C-terminal region to regulate TRPV1.
A combined coarse-grained and all-atom simulation of TRPV1 channel gating and heat activation
Coarse-grained modeling and all-atom molecular dynamics simulation provide insight into the mechanism for heat activation of TRPV1 gating.