Skip to Main Content

Advertisement

Close

About the Press
For Librarians
Rights & Permissions
Books Open External Link
Job Board Open External Link
JCB Journal of Cell Biology
JEM Journal of Experimental Medicine
JGP Journal of General Physiology
JHI Journal of Human Immunity
LSA Open External Link Life Science Alliance

JCB

JEM

JGP

JHI

LSA

header search

Search input auto suggest

filter your search

Advanced Search

Menu

- Special Collections
- Special Issues
Email Alerts
Job BoardOpen External Link

Issues

Select Decade

Select Year

Issue

Volume 140, Issue 5

1 November 2012

Journal of General Physiology Cover Image for Volume 140, Issue 5

Previous Issue
Next Issue

Cover Image

Cover Image

Cover picture: Intracellular TEA⁺ and NMG⁺ ions occupying the cavity of Kv1.2 channels stabilize the open state. The investigation by Goodchild et al. in this issue shows that ions in the open channel pore, including K⁺, are more than mere passengers. By exerting a resistance to pore closure and subsequent voltage sensor return, the presence of ions fundamentally modulates the gating of the channel (see article by Goodchild et al., 495–511).
Table of Contents
Editorial Board

ISSN 0022-1295

EISSN 1540-7748

In this Issue

Generally Physiological
Commentary
Article
Communication
Letter to the Editor
Journal Club

Generally Physiological

Taking a translational turn

Elizabeth M. Adler

View Articletitled, Taking a translational turn

Commentary

Unlocking the mechanisms of HCN channel gating with locked-open and locked-closed channels

Matthew C. Trudeau

View Articletitled, Unlocking the mechanisms of HCN channel gating with locked-open and locked-closed channels

Open-state stabilization in Kv channels: Voltage-sensor relaxation and pore propping by a bound ion

Robert J. French,Rocio K. Finol-Urdaneta

View Articletitled, Open-state stabilization in Kv channels: Voltage-sensor relaxation and pore propping by a bound ion

Article

Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate

Sujung Ryu,Gary Yellen

View Articletitled, Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate

Molecular mechanism for depolarization-induced modulation of Kv channel closure

Alain J. Labro,Jerome J. Lacroix,Carlos A. Villalba-Galea,Dirk J. Snyders,Francisco Bezanilla

View Articletitled, Molecular mechanism for depolarization-induced modulation of Kv channel closure

Basis for allosteric open-state stabilization of voltage-gated potassium channels by intracellular cations

Samuel J. Goodchild,Hongjian Xu,Zeineb Es-Salah-Lamoureux,Christopher A. Ahern,David Fedida

View Articletitled, Basis for allosteric open-state stabilization of voltage-gated potassium channels by intracellular cations

Modeling-independent elucidation of inactivation pathways in recombinant and native A-type Kv channels

Jeffrey D. Fineberg,David M. Ritter,Manuel Covarrubias

View Articletitled, Modeling-independent elucidation of inactivation pathways in recombinant and native A-type Kv channels

Interactions of external K⁺ and internal blockers in a weak inward-rectifier K⁺ channel

Lei Yang,Johan Edvinsson,Lawrence G. Palmer

View Articletitled, Interactions of external K<sup>+</sup> and internal blockers in a weak inward-rectifier K<sup>+</sup> channel

Distinct properties of Ca²⁺–calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel

Sze-Yi Lau,Erik Procko,Rachelle Gaudet

View Articletitled, Distinct properties of Ca<sup>2+</sup>–calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel

Communication

Cellular context and multiple channel domains determine cAMP sensitivity of HCN4 channels: Ligand-independent relief of autoinhibition in HCN4

Zhandi Liao,Dean Lockhead,Joshua R. St. Clair,Eric D. Larson,Courtney E. Wilson,Catherine Proenza

View Articletitled, Cellular context and multiple channel domains determine cAMP sensitivity of HCN4 channels: Ligand-independent relief of autoinhibition in HCN4

Letter to the Editor

Mitochondria-targeted cpYFP: pH or superoxide sensor?

Emilie Quatresous,Claude Legrand,Sandrine Pouvreau

View Articletitled, Mitochondria-targeted cpYFP: pH or superoxide sensor?

Journal Club

Purinergic regulation of inflammasome activation after central nervous system injury

Louis-Philippe Bernier

View Articletitled, Purinergic regulation of inflammasome activation after central nervous system injury

Email alerts

Complete Issue Alert

Daily Publication Alert

Most Read

TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells

The physical basis of osmosis

Voltage-Gated Na Channels

Drugs exhibit diverse binding modes and access routes in the Na_v1.5 cardiac sodium channel pore

Probenecid affects muscle Ca²⁺ homeostasis and contraction independently from pannexin channel block

Mechanotransduction by Membrane Proteins

Mechanosensitive channel MscS is critical for termination of the bacterial hypoosmotic permeability response

Advertisement

Newest Articles
Current Issue
Archive
Alerts

Submit a Manuscript
Instructions for Authors
For Librarians
About JGP

Editors & Staff
Policies & Permissions
Accessibility Statement
Cookie Policy

Terms & Conditions
Advertise
Contact Us
Newsroom

Privacy Policy
RSS Feeds

Facebook
X/Twitter
Instagram
YouTube
LinkedIn
Bluesky

© 2026 Rockefeller University Press

Cookie Settings

Online ISSN 1540-7748
Print ISSN 0022-1295

This Feature Is Available To Subscribers Only

Sign In or Create an Account

Sharing Unavailable

Sharing content requires targeting cookies to be enabled. Please update your cookie preferences to use this feature.