Issues

Cover picture: New insights into the mechanism of CFTR gating. Our previous report uncovered a post-hydrolytic state (state X, embedded in an opening burst) that can bind ATP and reenter the prehydrolytic open state (O1) for another round of ATP hydrolysis. In the current study, this open-to-open transition can be “seen” with a CFTR mutant, revealing non-strict coupling between the gating cycle and the ATP hydrolysis cycle (see article by Jih et al., 347–359).