Issues

Cover picture: Effects of site-directed mutagenesis of the carboxy-terminal A-B inter-helix linker of Kv7.2 channels on single-channel open probability correlate with docking simulations of a PIP₂ analog. Recordings of R463Q (top) or R463E (bottom) mutants at 0 mV in cell-attached mode (left) or inside-out mode in the presence of 25 µM diC8-PIP₂ (right). The simulations below the traces predict a much more favorable interaction for the R463E mutant (see article by Hernandez et al., 361–381).