Journal of Experimental Medicine (JEM) | Rockefeller University Press

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Innate Immune Signaling in Infection and Disease

A special collection of recent articles in JEM.
Updates on The Immune Responses in Tuberculosis

A special collection of recent articles in JEM.

Newest Articles

Article

| March 31 2026

Proinflammatory functions of Blimp-1 in ILC2s

Patrycja M. Forster et al.

Forster et al. identify the transcriptional network controlling effector functions of ILC2s downstream of the IL-33 receptor. They found that the Blimp-1–IRF4 axis regulates IL-5 and IL-13 production in ILC2s, driving either worm expulsion or eosinophilia during allergic lung inflammation.

Article

| March 27 2026

MEKK3–KLF2/4 signaling activates TIE2 in CCM

Lun Li et al.

Endothelial cell gain of MEKK3–KLF2/4 signaling confers CCM by increasing PI3K signaling. We show that the TIE2 receptor links MEKK3–KLF2/4 and PI3K signaling during CCM formation, identifying TIE2 inhibition as a potential treatment strategy for CCM disease.

Article

| March 27 2026

Targeting Mettl8–Tcf1 to reprogram T_PEX

Jiaxi Song et al.

The study reveals that Mettl8 maintains stem-like T_PEX cells by stabilizing Tcf1 via m³C modification and facilitating chromatin looping at the Tox locus. Its deletion or inhibition drives T_PEX differentiation into effective Int-T_EX cells, restraining tumor growth and synergizing with anti–PD-1 therapy, thus presenting a promising immunotherapeutic target.

Article

| March 26 2026

Basophils drive wounds resolution

Julie Bex et al.

The resolution of inflammation is essential for homeostasis and becomes defective with age. Here, Bex et al. show that basophils infiltrate wounds to promote the resolution and healing in both adult and aged mice.

Technical Advances and Resources

| March 25 2026

In vivo gene editing of fibroblasts

Nicholas F. Kuhn et al.

CAFs are prominent members of the TME. Kuhn et al. demonstrate how local gene editing of CAFs alters their cell state and, subsequently, the cellular TME. This approach demonstrates a method to investigate intercellular circuits using targeted genetic perturbations in CAFs.

Article

| March 25 2026

MYCT1–IFITM2/3 restrains endothelial energy waste

Laureline Wetterwald et al.

Wetterwald, Köck et al. report the existence of an endothelial metabolic checkpoint where MYCT1 restricts activity of IFITM2/3 to prevent energy waste at the vascular barrier and enable fat storage. This mechanism links endothelial nutrient handling to systemic energy balance, opening new directions for tackling obesity and metabolic disease.

Article

| March 24 2026

DNA-PK traps cyclic dinucleotides

Isabelle K. Vila et al.

CDN are second messengers that trigger type I IFN responses. Vila et al. show that DNA-PKcs, a major DNA damage response actor, directly interacts with CDNs through its kinase domain, ensuring CDN-associated signal termination, while CDNs inhibit DNA-PKcs catalytic activity.

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Current Issue

Volume 223,

Issue 3,

2 March 2026

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Reviews & Opinions

Review | Cancer Focus

| March 31 2026

Inhibitory receptor agonists

Kieran R. Adam et al.

In this review, Adam et al. highlights the challenges and novel approaches to developing agonistic IR-targeted therapies to treat autoimmunity and inflammatory disorders.

Insights

| March 25 2026

The endothelium is a checkpoint for energy storage

M. Luisa Iruela-Arispe

Wetternwald and colleagues show that endothelial cells actively regulate energy storage in white adipose tissue through MYCT1–IFITM2/3-dependent control of endolysosomal trafficking and mTORC1 signaling. By limiting their own nutrient consumption, endothelial cells influence systemic energy partitioning, redefining the vasculature as a metabolic gatekeeper rather than a passive conduit.

Review | Genes and Immunity Focus

| March 23 2026

Monoallelic expression—determinant of penetrance

Dusan Bogunovic

Humans are disomic, with paired maternal and paternal autosomes presumed equally expressed. Autosomal random monoallelic expression challenges this paradigm and may underlie incomplete penetrance in diverse genetic diseases while allowing for personal evolution within the inherited genetic constraints.

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Special Collections

The Year in Experimental Medicine

Our annual series highlighting articles that were of greatest interest to our readers in 2025.

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How to comply with NIH and HHMI publication policies.

Discover how JEM’s collaborative model puts your science first.

A special collection of recent articles in JEM.

A special collection of recent articles in JEM.

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Special Collections