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Journal Articles

Flawed translation triggers oncogenic B–T cell communication

Seren Baygün, Marc Schmidt-Supprian
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (8): e20260912.
https://doi.org/10.1084/jem.20260912
Published: 24 June 2026
View article titled, Flawed translation triggers oncogenic B–T cell communication
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Journal Articles

UBE2F impedes CD8 T cell memory

Li Zhong, Hua Gu
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (7): e20260995.
https://doi.org/10.1084/jem.20260995
Published: 22 June 2026
View article titled, UBE2F impedes CD8 T cell memory
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Journal Articles

Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells

Hyunu Kim, Simon Grassmann, Wilfred Wong, Nicholas M. Adams, Yuka Kanno, John J. O’Shea, Christina S. Leslie, Inez Rogatsky, Joseph C. Sun
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (8): e20250995.
https://doi.org/10.1084/jem.20250995
Published: 18 June 2026
View article titled, Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells
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Journal Articles

BCL6 is required for the development of functionally responsive IgM+ GC Tfh–independent memory B cells

Gretchen Harms Pritchard, Akshay T. Krishnamurty, Lauren B. Rodda, Christopher D. Thouvenel, Derek J. Bangs, Courtney E. McDougal, Laila Shehata, David J. Rawlings, Marion Pepper
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (8): e20252336.
https://doi.org/10.1084/jem.20252336
Published: 10 June 2026
View article titled, BCL6 is required for the development of functionally responsive IgM+ GC Tfh–independent memory B cells
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Includes: Supplementary data
Journal Articles

Bidirectional regulation by BACH2 coordinates systemic CXCR5− vs. CXCR5+ CD4+ T cell differentiation

Andrew R. Schroeder, Fangming Zhu, Xianyou Xia, Hui Hu
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (8): e20251959.
https://doi.org/10.1084/jem.20251959
Published: 08 June 2026
View article titled, Bidirectional regulation by BACH2 coordinates systemic CXCR5− vs. CXCR5+ CD4+ T cell differentiation
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Includes: Supplementary data
Journal Articles

eIF3e-mediated translational checkpoint maintains immune tolerance and prevents lymphoid malignancy

Lianghua Lin, Pengda Chen, Jiazhen Wang, Chao Huang, Xinyong Lin, Chenfeng Liu, Kunyu Liao, Jianfeng Wu, Amy Chadburn, Yunjie Zhang, Huilin Song, Chenxi Wang, Zhichen Wan, Jiayi Zhao, Guangyi Cao, Xinming Wang, Liang Yang, Nan Yao, Yazhen Hong, Zhengtao Xiao, Dieter A. Wolf, Wen-Hsien Liu, Changchun Xiao
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (8): e20251968.
https://doi.org/10.1084/jem.20251968
Published: 03 June 2026
View article titled, eIF3e-mediated translational checkpoint maintains immune tolerance and prevents lymphoid malignancy
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Includes: Supplementary data
Journal Articles

Cathepsin S regulates germinal center reactions and anti-tumor humoral responses

Marine Bruand, Divyanshu Srivastava, Aaron Petruzzella, Maxime Petit, Samantha Mahfoud, Natalya Katanayeva, Asli Kasapoglu, Camille Landragin, Daniele Tavernari, Eleni Balli, Giovanni Ciriello, Tatiana V. Petrova, Elisa Oricchio
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (7): e20252463.
https://doi.org/10.1084/jem.20252463
Published: 01 June 2026
View article titled, Cathepsin S regulates germinal center reactions and anti-tumor humoral responses
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Includes: Supplementary data
Journal Articles

Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity

Xiaonan Ma, Henan Guo, Yuting Jia, Na Yin, Min Peng
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (7): e20252687.
https://doi.org/10.1084/jem.20252687
Published: 26 May 2026
View article titled, Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity
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Includes: Supplementary data
Journal Articles

Reprogramming endogenous NK circuits by highly efficient nonviral genome editing

Rih-Sheng Huang, Shee Kwan Phung, Darin Sumstad, Anna J. Weis, Quinlan M. Kile, Laura Bendzick, Melissa J. Khaw, Young Y. Vue, David H. McKenna, Philippa R. Kennedy, Jeffrey S. Miller, Martin Felices
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (7): e20260192.
https://doi.org/10.1084/jem.20260192
Published: 13 May 2026
View article titled, Reprogramming endogenous NK circuits by highly efficient nonviral genome editing
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Includes: Supplementary data
Journal Articles

Epithelial chemokine CCL25 integrates T cell development and intestinal homeostasis

Jie Li, Mei-Ting Yang, Mami Matsuda-Lennikov, Felix Kalle-Youngoue, Aya Ushio, Kenta Kondo, Meleca Gluckman, Kana Bando, Takaya Abe, Kensuke Takada, Michael C. Kelly, Felipe Castro Martinez, Zuojia Chen, Chuan Wu, Yousuke Takahama
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (6): e20252527.
https://doi.org/10.1084/jem.20252527
Published: 12 May 2026
View article titled, Epithelial chemokine CCL25 integrates T cell development and intestinal homeostasis
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Includes: Supplementary data
Journal Articles

CNOT3 supports ILC2 differentiation and function by destabilizing Tbx21 and Rorc transcripts

Megumi Tatematsu, Shunsuke Takasuga, Akane Fuchimukai, Yuumi Kimura, Satoshi Ishii, Ichiro Taniuchi, Kenji Ishiwata, Koichi Ikuta, Veronika Sexl, Gérard Eberl, Shinichiro Sawa, Keiji Kuba, Takashi Ebihara
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (7): e20250895.
https://doi.org/10.1084/jem.20250895
Published: 12 May 2026
View article titled, CNOT3 supports ILC2 differentiation and function by destabilizing Tbx21 and Rorc transcripts
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Includes: Supplementary data
Journal Articles

Complement-regulated homeostatic proliferation controls memory B cell longevity and repertoire composition

Evan W. Cody, Mehek Ningoo, Isha Monga, Alexander M. Tsankov, Hiromi Muramatsu, Norbert Pardi, Miguel Fribourg, Peter S. Heeger, David Dominguez-Sola
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (7): e20251048.
https://doi.org/10.1084/jem.20251048
Published: 08 May 2026
View article titled, Complement-regulated homeostatic proliferation controls memory B cell longevity and repertoire composition
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Includes: Supplementary data
Journal Articles

TACI regulates marginal zone B cell development

Daisy H. Luff, Lesley Vanes, Stefan Boeing, Victor L.J. Tybulewicz
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (6): e20251308.
https://doi.org/10.1084/jem.20251308
Published: 05 May 2026
View article titled, TACI regulates marginal zone B cell development
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Includes: Supplementary data
Journal Articles

TACItness MZ B cell maturation

Mauricio Guzmán, Martyna Filipska, Andrea Cerutti
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (6): e20260401.
https://doi.org/10.1084/jem.20260401
Published: 05 May 2026
View article titled, TACItness MZ B cell maturation
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Journal Articles

Rab5 improves CAR T cell efficacy via reducing fratricide and maintaining surface CAR levels

In Special Collection:
JEM Clinical Immunology Collection 2026
Meidi Gu, Kaitlin A. Read, Vipin Bhardwaj, Edmund J. Carvalho, David Nardo, Justin C. Shayne, Divanshu Shukla, Wei Liu, Donald L. Siegel, Neil C. Sheppard, Michael C. Milone, Adam D. Cohen, Alfred L. Garfall, James L. Riley
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (6): e20252564.
https://doi.org/10.1084/jem.20252564
Published: 05 May 2026
View article titled, Rab5 improves CAR T cell efficacy via reducing fratricide and maintaining surface CAR levels
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Includes: Supplementary data
Journal Articles

Tet2 deficiency alters CD4+ T cell function and promotes T cell lymphoma with a TFH cell immunophenotype

Tayla B. Heavican-Foral, Yuping Li, Waseem Lone, Alyssa Bouska, Jibin Zhang, Ruimeng Yang, Xuxiang Liu, Ab Rauf Shah, Abdul Rouf Mir, Joseph Rohr, Dylan Jochum, Anurag Kumar, Ravneet Singh Chawla, Catalina Amador, Jiayu Yu, Tyler Herek, Jacob Robinson, Chengfeng Bi, Sunandini Sharma, Tyler Gilbreath, R. Katherine Hyde, Timothy W. McKeithan, Chan-Wang Lio, Anjana Rao, Giorgio Inghirami, Joesph Khoury, Wing C. Chan, Javeed Iqbal
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (6): e20250194.
https://doi.org/10.1084/jem.20250194
Published: 28 April 2026
View article titled, Tet2 deficiency alters CD4+ T cell function and promotes T cell lymphoma with a TFH cell immunophenotype
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Includes: Supplementary data
Journal Articles

LINGO4 coordinates ILC3-intrinsic IL-22 production and microbiota-mediated ILC3 homeostasis

José L. Fachi, Tihana Trsan, Cristiane Sécca, Sarah de Oliveira, Vinícius R. Rodovalho, Patrick Fernandes Rodrigues, Wandy L. Beatty, Raki Sudan, Shitong Wu, Bishan Bhattarai, Santosh K. Panda, Marina Cella, Susan Gilfillan, Marco Colonna
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (6): e20252632.
https://doi.org/10.1084/jem.20252632
Published: 28 April 2026
View article titled, LINGO4 coordinates ILC3-intrinsic IL-22 production and microbiota-mediated ILC3 homeostasis
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Includes: Supplementary data
Journal Articles

Antibody-mediated diversification of primary and secondary humoral immune responses

Dennis Schaefer-Babajew, Laurine Binet, Gabriela S. Silva Santos, Chiara Ruprecht, Lachlan P. Deimel, Mohamed A. ElTanbouly, Dounia Gharrassi, Gabriella Lima dos Reis, Clara Uhe, Kai-Hui Yao, Brianna Hernandez, Parul Agrawal, Anna Gazumyan, Leonidas Stamatatos, Harald Hartweger, Michel C. Nussenzweig
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (6): e20252590.
https://doi.org/10.1084/jem.20252590
Published: 28 April 2026
View article titled, Antibody-mediated diversification of primary and secondary humoral immune responses
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Includes: Supplementary data
Journal Articles

AID and TET2 cooperate to demethylate Irf4 for plasma cell fate in germinal center B cells

Minghui He, Roberta D’Aulerio, Lia G. Pinho, Evangelos Doukoumopoulos, Tracer Yong, Rhaissa C. Vieira, Mariana M.S. Oliveira, Laura Eiben, Manon Termote, Rômulo G. Galvani, Saikiran Sedimbi, Christina Seitz, Nikolai V. Kuznetsov, Maria A. Zuriaga, Daisuke Kitamura, José J. Fuster, Vinicius Cotta-de-Almeida, Lena Ström, Pia Dosenovic, Søren E. Degn, Lisa S. Westerberg
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (6): e20260096.
https://doi.org/10.1084/jem.20260096
Published: 27 April 2026
View article titled, AID and TET2 cooperate to demethylate Irf4 for plasma cell fate in germinal center B cells
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Includes: Supplementary data
Journal Articles

Inhibitory receptor agonists: Emerging strategies in immune modulation

In Special Collection:
Inflammation Resolution 2026
Kieran R. Adam, Aamir Suhail, Vijay K. Kuchroo, Dario A.A. Vignali
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2026) 223 (4): e20241217.
https://doi.org/10.1084/jem.20241217
Published: 31 March 2026
View article titled, Inhibitory receptor agonists: Emerging strategies in immune modulation
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