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DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells

J Exp Med (2026) 223 (3): e20241707.

https://doi.org/10.1084/jem.20241707

Published: 28 January 2026

View article titled, DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells

Includes: Supplementary data

Journal Articles

Epigenetic and metabolic reprogramming support plasma cell differentiation in germinal centers

Yuliang Wang, Xinyi Yang, Mengting Lou, Tiantian Chen, Wen Li, Cuifang Yang, Le Zhang, Zhenming Cai, Yuren Fan, Sulan Zhai, Shengze Zhang, Yunli Wang, Xiaoming Wang, Jingjing Chen

J Exp Med (2026) 223 (3): e20250569.

https://doi.org/10.1084/jem.20250569

Published: 28 January 2026

View article titled, Epigenetic and metabolic reprogramming support plasma cell differentiation in germinal centers

Journal Articles

FOXO1 re-expression with a dual-recombinase allele rescues class switching in germinal center B cells

Carlota Farré Díaz, Eleni Kabrani, Wiebke Winkler, Eric Blanc, Brigitte Wollert-Wulf, Claudia Salomon, F. Thomas Wunderlich, Dieter Beule, Martin Janz, Klaus Rajewsky

J Exp Med (2025) 223 (3): e20241136.

https://doi.org/10.1084/jem.20241136

Published: 26 December 2025

View article titled, FOXO1 re-expression with a dual-recombinase allele rescues class switching in germinal center B cells

Includes: Supplementary data

Journal Articles

FIP200 regulates plasma B cell differentiation via mitochondrial and heme homeostasis

Liling Xu, Maria Bottermann, Paula M. Villavicencio, John Warner, Stephanie R. Weldon, Zhenfei Xie, Andrew Filby, Xiaotie Liu, Ian G. Ganley, Alison E. Ringel, Usha Nair, Facundo D. Batista

J Exp Med (2025) 223 (3): e20250535.

https://doi.org/10.1084/jem.20250535

Published: 17 December 2025

View article titled, FIP200 regulates plasma B cell differentiation via mitochondrial and heme homeostasis

Includes: Supplementary data

Journal Articles

Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood

In Special Collection:

Immunology Update Winter 2026

Gabrielle R. LeBlanc, Adam L. Sobel, Jonathan Melamed, Dominic Haas, Eduard Ansaldo, Aiko M. Cirone, Elizabeth Murguia, Michael G. Constantinides

J Exp Med (2025) 223 (3): e20241287.

https://doi.org/10.1084/jem.20241287

Published: 16 December 2025

View article titled, Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood

Journal Articles

REV-ERB regulates RORγt⁺ regulatory T cell specification and function through the Bhlhe40-c-Maf axis

Xianting Hu, Zhi Liu, Yao Li, Yannan You, Kaiye Yue, Yuqiong Liang, Chin-San Loo, Jingting Yu, Matthias Leblanc, Dehui Wang, Huabin Li, Ye Zheng

J Exp Med (2025) 223 (2): e20241463.

https://doi.org/10.1084/jem.20241463

Published: 08 December 2025

View article titled, REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis

Includes: Supplementary data

Journal Articles

Dynamics of natural and pharmacologic control of an SIV variant with an envelope trafficking defect

J Exp Med (2025) 223 (2): e20251172.

https://doi.org/10.1084/jem.20251172

Published: 05 December 2025

View article titled, Dynamics of natural and pharmacologic control of an SIV variant with an envelope trafficking defect

Includes: Supplementary data

Journal Articles

Notch interaction with RUNX factors regulates initiation of the T-lineage program

Yuichi Kama, Ken-ichi Hirano, Kaori Masuhara, Yusuke Endo, Yuka Suzuki, Masanori Fujimoto, Tatsuma Matsuda, Takashi Yahata, Masahiko Kato, Katsuto Hozumi, Tomoaki Tanaka, Hiroyuki Hosokawa

J Exp Med (2025) 223 (2): e20250911.

https://doi.org/10.1084/jem.20250911

Published: 04 December 2025

View article titled, Notch interaction with RUNX factors regulates initiation of the T-lineage program

Includes: Supplementary data

Journal Articles

A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes

Lisa Kurz, Mechthild Lütge, Angelina De Martin, Hung-Wei Cheng, Elina Bugar, Yves Stanossek, Samuel Meili, Joshua D. Brandstadter, Ivan Maillard, Lucas Onder, Burkhard Ludewig

J Exp Med (2025) 223 (2): e20242300.

https://doi.org/10.1084/jem.20242300

Published: 26 November 2025

View article titled, A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes

Includes: Supplementary data

Journal Articles

Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells

Matouš Vobořil, Fernando Bandeira Sulczewski, Ryan J. Martinez, K. Maude Ashby, Michael Manoharan Valerio, Juliana Idoyaga, Kristin A. Hogquist

J Exp Med (2025) 223 (1): e20250733.

https://doi.org/10.1084/jem.20250733

Published: 22 October 2025

View article titled, Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells

Journal Articles

FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes

Niccolò Bianchi, Elena Foli, Mehrpouya Mostanfar, Roberta Marzi, Mara Cetty Spinella, Sara Polletti, Matteo Pecoraro, Antonino Cassotta, Roshan Thakur, David Jarrossay, Federica Sallusto, Gioacchino Natoli, Silvia Monticelli

J Exp Med (2025) 223 (1): e20242474.

https://doi.org/10.1084/jem.20242474

Published: 15 October 2025

View article titled, FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes

Includes: Supplementary data

Journal Articles

CD2 and its ligands are involved in development and activation of MAIT cells

Kaiwen Zhu, Jiayu Dou, Bin Li, Jin Qian, Ming-Chao Zhong, Zhenghai Tang, Yan Lu, André Veillette

J Exp Med (2025) 222 (12): e20250431.

https://doi.org/10.1084/jem.20250431

Published: 30 September 2025

View article titled, CD2 and its ligands are involved in development and activation of MAIT cells

Journal Articles

Human CD4⁺ T cells recognize Mycobacterium tuberculosis–infected macrophages amid broader responses

In Special Collection:

2025: The Year in Experimental Medicine

Volodymyr Stetsenko, Daniel P. Gail, Scott M. Reba, Vinicius G. Suzart, Robert Schauner, Avinaash K. Sandhu, Alessandro Sette, Mohammad Haj Dezfulian, Cecilia S. Lindestam Arlehamn, Stephen M. Carpenter

J Exp Med (2025) 222 (12): e20250460.

https://doi.org/10.1084/jem.20250460

Published: 24 September 2025

View article titled, Human CD4+ T cells recognize Mycobacterium tuberculosis–infected macrophages amid broader responses

Includes: Supplementary data

Journal Articles

Invariant TCR-triggered protein kinase D activation mediates NKT cell development

Eri Ishikawa, Hidetaka Kosako, Daisuke Motooka, Mai Imasaka, Hiroshi Watarai, Masaki Ohmuraya, Sho Yamasaki

J Exp Med (2025) 222 (12): e20250541.

https://doi.org/10.1084/jem.20250541

Published: 18 September 2025

View article titled, Invariant TCR-triggered protein kinase D activation mediates NKT cell development

Includes: Supplementary data

Journal Articles

Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies

J Exp Med (2025) 222 (10): e20250638.

https://doi.org/10.1084/jem.20250638

Published: 18 August 2025

View article titled, Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies

Includes: Supplementary data

Journal Articles

Epigenetic priming as a driver of memory recall and dysfunction in T cells

Mieke Metzemaekers, Niels J. Rinzema, Ralph Stadhouders

J Exp Med (2025) 222 (9): e20241433.

https://doi.org/10.1084/jem.20241433

Published: 31 July 2025

View article titled, Epigenetic priming as a driver of memory recall and dysfunction in T cells

Journal Articles

ALK2/3 recruitment to the immunological synapse is required for T cell activation and death

Jun-Ge Shi, Zhen-Wu Ma, Zi-Lun Ruan, Ye Xu, Wen-Hao Hang, Rui Liu, Yong Xiong, Hong-Bing Shu, Shu Li

J Exp Med (2025) 222 (10): e20250121.

https://doi.org/10.1084/jem.20250121

Published: 30 July 2025

View article titled, ALK2/3 recruitment to the immunological synapse is required for T cell activation and death

Includes: Supplementary data

Journal Articles

Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein

In Special Collection:

Journal-Based CME Activities with Journal of Experimental Medicine (JEM)

Hannah van Dijk, Ilka Wahl, Sara Kraker, Paul M. Robben, Sheetij Dutta, Hedda Wardemann

J Exp Med (2025) 222 (9): e20250044.

https://doi.org/10.1084/jem.20250044

Published: 10 July 2025

View article titled, Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein

Includes: Supplementary data

Journal Articles

Costimulatory connections: CARMIL2 and CD28

Lawrence P. Kane

J Exp Med (2025) 222 (8): e20250896.

https://doi.org/10.1084/jem.20250896

Published: 20 June 2025

View article titled, Costimulatory connections: CARMIL2 and CD28

Journal Articles

HDAC1 controls the generation and maintenance of effector-like CD8⁺ T cells during chronic viral infection

Ramona Rica, Monika Waldherr, Emi Miyakoda, Ana Patricia Kutschat, Marlene Schülein, Jing Zhang, Ricardo Alfredo Orbegozo-Medina, Lisa Sandner, Valentina Stolz, Darina Waltenberger, Thomas Krausgruber, Christoph Bock, Nicole Boucheron, Davide Seruggia, Wilfried Ellmeier, Shinya Sakaguchi

J Exp Med (2025) 222 (8): e20240829.

https://doi.org/10.1084/jem.20240829

Published: 04 June 2025

View article titled, HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection

Includes: Supplementary data

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DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells

Epigenetic and metabolic reprogramming support plasma cell differentiation in germinal centers

FOXO1 re-expression with a dual-recombinase allele rescues class switching in germinal center B cells

FIP200 regulates plasma B cell differentiation via mitochondrial and heme homeostasis

Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood

REV-ERB regulates RORγt⁺ regulatory T cell specification and function through the Bhlhe40-c-Maf axis

Dynamics of natural and pharmacologic control of an SIV variant with an envelope trafficking defect

Notch interaction with RUNX factors regulates initiation of the T-lineage program

A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes

Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells

FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes

CD2 and its ligands are involved in development and activation of MAIT cells

Human CD4⁺ T cells recognize Mycobacterium tuberculosis–infected macrophages amid broader responses

Invariant TCR-triggered protein kinase D activation mediates NKT cell development

Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies

Epigenetic priming as a driver of memory recall and dysfunction in T cells

ALK2/3 recruitment to the immunological synapse is required for T cell activation and death

Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein

Costimulatory connections: CARMIL2 and CD28

HDAC1 controls the generation and maintenance of effector-like CD8⁺ T cells during chronic viral infection

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