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Journal Articles

A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes

Lisa Kurz, Mechthild Lütge, Angelina De Martin, Hung-Wei Cheng, Elina Bugar, Yves Stanossek, Samuel Meili, Joshua D. Brandstadter, Ivan Maillard, Lucas Onder, Burkhard Ludewig
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (2): e20242300.
https://doi.org/10.1084/jem.20242300
Published: 26 November 2025
View article titled, A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes
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Includes: Supplementary data
Journal Articles

Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells

Matouš Vobořil, Fernando Bandeira Sulczewski, Ryan J. Martinez, K. Maude Ashby, Michael Manoharan Valerio, Juliana Idoyaga, Kristin A. Hogquist
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20250733.
https://doi.org/10.1084/jem.20250733
Published: 22 October 2025
View article titled, Thymic myeloid cells are heterogenous and include a novel population of transitional dendritic cells
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Journal Articles

FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes

Niccolò Bianchi, Elena Foli, Mehrpouya Mostanfar, Roberta Marzi, Mara Cetty Spinella, Sara Polletti, Matteo Pecoraro, Antonino Cassotta, Roshan Thakur, David Jarrossay, Federica Sallusto, Gioacchino Natoli, Silvia Monticelli
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20242474.
https://doi.org/10.1084/jem.20242474
Published: 15 October 2025
View article titled, FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes
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Includes: Supplementary data
Journal Articles

CD2 and its ligands are involved in development and activation of MAIT cells

Kaiwen Zhu, Jiayu Dou, Bin Li, Jin Qian, Ming-Chao Zhong, Zhenghai Tang, Yan Lu, André Veillette
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (12): e20250431.
https://doi.org/10.1084/jem.20250431
Published: 30 September 2025
View article titled, CD2 and its ligands are involved in development and activation of MAIT cells
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Journal Articles

Human CD4+ T cells recognize Mycobacterium tuberculosis–infected macrophages amid broader responses

Volodymyr Stetsenko, Daniel P. Gail, Scott M. Reba, Vinicius G. Suzart, Robert Schauner, Avinaash K. Sandhu, Alessandro Sette, Mohammad Haj Dezfulian, Cecilia S. Lindestam Arlehamn, Stephen M. Carpenter
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (12): e20250460.
https://doi.org/10.1084/jem.20250460
Published: 24 September 2025
View article titled, Human CD4+ T cells recognize Mycobacterium tuberculosis–infected macrophages amid broader responses
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Includes: Supplementary data
Journal Articles

Invariant TCR-triggered protein kinase D activation mediates NKT cell development

Eri Ishikawa, Hidetaka Kosako, Daisuke Motooka, Mai Imasaka, Hiroshi Watarai, Masaki Ohmuraya, Sho Yamasaki
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (12): e20250541.
https://doi.org/10.1084/jem.20250541
Published: 18 September 2025
View article titled, Invariant TCR-triggered protein kinase D activation mediates NKT cell development
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Includes: Supplementary data
Journal Articles

Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies

Ryan S. Roark, Rumi Habib, Jason Gorman, Hui Li, Andrew Jesse Connell, Mattia Bonsignori, Yicheng Guo, Michael P. Hogarty, Adam S. Olia, Kirsten J. Sowers, Baoshan Zhang, Frederic Bibollet-Ruche, Tatsiana Bylund, Sean Callaghan, John W. Carey, Gabriele Cerutti, Darcy R. Harris, Wanting He, Emily Lewis, Tracy Liu, Rosemarie D. Mason, Yujie Qiao, Younghoon Park, Juliette M. Rando, Ajay Singh, Jeremy J. Wolff, Q. Paula Lei, Mark K. Louder, Raiees Andrabi, Nicole A. Doria-Rose, Kevin O. Saunders, Michael S. Seaman, Barton F. Haynes, Daniel W. Kulp, John R. Mascola, Mario Roederer, Theodore C. Pierson, Zizhang Sheng, Beatrice H. Hahn, George M. Shaw, Peter D. Kwong, Lawrence Shapiro
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (10): e20250638.
https://doi.org/10.1084/jem.20250638
Published: 18 August 2025
View article titled, Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies
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Includes: Supplementary data
Journal Articles

Epigenetic priming as a driver of memory recall and dysfunction in T cells

Mieke Metzemaekers, Niels J. Rinzema, Ralph Stadhouders
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20241433.
https://doi.org/10.1084/jem.20241433
Published: 31 July 2025
View article titled, Epigenetic priming as a driver of memory recall and dysfunction in T cells
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Journal Articles

ALK2/3 recruitment to the immunological synapse is required for T cell activation and death

Jun-Ge Shi, Zhen-Wu Ma, Zi-Lun Ruan, Ye Xu, Wen-Hao Hang, Rui Liu, Yong Xiong, Hong-Bing Shu, Shu Li
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (10): e20250121.
https://doi.org/10.1084/jem.20250121
Published: 30 July 2025
View article titled, ALK2/3 recruitment to the immunological synapse is required for T cell activation and death
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Includes: Supplementary data
Journal Articles

Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein

In Special Collection:
Journal-Based CME Activities with Journal of Experimental Medicine (JEM)
Hannah van Dijk, Ilka Wahl, Sara Kraker, Paul M. Robben, Sheetij Dutta, Hedda Wardemann
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20250044.
https://doi.org/10.1084/jem.20250044
Published: 10 July 2025
View article titled, Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein
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Includes: Supplementary data
Journal Articles

Costimulatory connections: CARMIL2 and CD28

Lawrence P. Kane
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20250896.
https://doi.org/10.1084/jem.20250896
Published: 20 June 2025
View article titled, Costimulatory connections: CARMIL2 and CD28
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Journal Articles

HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection

Ramona Rica, Monika Waldherr, Emi Miyakoda, Ana Patricia Kutschat, Marlene Schülein, Jing Zhang, Ricardo Alfredo Orbegozo-Medina, Lisa Sandner, Valentina Stolz, Darina Waltenberger, Thomas Krausgruber, Christoph Bock, Nicole Boucheron, Davide Seruggia, Wilfried Ellmeier, Shinya Sakaguchi
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20240829.
https://doi.org/10.1084/jem.20240829
Published: 04 June 2025
View article titled, HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection
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Includes: Supplementary data
Journal Articles

IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints

Adam J. Fike, Kristen N. Bricker, Michael V. Gonzalez, Anju Maharjan, Tien Bui, Keomonyroth Nuon, Scott M. Emrich, Julia L. Weber, Sara A. Luckenbill, Nicholas M. Choi, Renan Sauteraud, Dajiang J. Liu, Nancy J. Olsen, Roberto Caricchio, Mohamed Trebak, Sathi Babu Chodisetti, Ziaur S.M. Rahman
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20231882.
https://doi.org/10.1084/jem.20231882
Published: 29 May 2025
View article titled, IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints
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Journal Articles

A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo

Fanghui Zhang, Javier Celis-Gutierrez, Lichen Zhang, Valentin Mellado, Léna Gelard, Sophie Panigot, Daiki Mori, Liaoxun Lu, Guillaume Voisinne, Carine Vilarnau Wolek, Marielle Mello, Odile Burlet-Schiltz, Anne Gonzalez de Peredo, Frédéric Fiore, Romain Roncagalli, Yinming Liang, Marie Malissen, Bernard Malissen
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20250339.
https://doi.org/10.1084/jem.20250339
Published: 22 May 2025
View article titled, A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo
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Includes: Supplementary data
Journal Articles

Defining molecular circuits of CD8+ T cell responses in tissues during latent viral infection

Endi K. Santosa, Jennifer M. Zhang, John C. Sauter, Mariah E. Lee, Brandon D. Ng, Sigrun V. Stulz, Meril Takizawa, Simon Grassmann, Orr-El Weizman, Nicholas M. Adams, Ronan Chaligné, Annette Oxenius, Georg Gasteiger, Colleen M. Lau, Joseph C. Sun
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20242078.
https://doi.org/10.1084/jem.20242078
Published: 19 May 2025
View article titled, Defining molecular circuits of CD8+ T cell responses in tissues during latent viral infection
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Includes: Supplementary data
Journal Articles

BCOR and ZC3H12A suppress a core stemness program in exhausted CD8+ T cells

Jing Xu, Zeran Jia, Xiaocui Zhao, Lixia Wang, Gang Jin, Zhuoyang Li, Na Yin, Yinqing Li, Min Peng
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20241133.
https://doi.org/10.1084/jem.20241133
Published: 06 May 2025
View article titled, BCOR and ZC3H12A suppress a core stemness program in exhausted CD8+ T cells
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Includes: Supplementary data
Journal Articles

Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination

Michael T. Conlon, Jessica Y. Huang, Michael Y. Gerner
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20241311.
https://doi.org/10.1084/jem.20241311
Published: 30 April 2025
View article titled, Lymphatic chain gradients regulate the magnitude and heterogeneity of T cell responses to vaccination
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Includes: Supplementary data
Journal Articles

Vaccination against influenza viruses annually: Renewing or narrowing the protective shield?

Hanover C. Matz, Ali H. Ellebedy
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20241283.
https://doi.org/10.1084/jem.20241283
Published: 24 April 2025
View article titled, Vaccination against influenza viruses annually: Renewing or narrowing the protective shield?
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Journal Articles

Microglia and CD8+ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15

In Special Collection:
Neuroscience Collection 2025 , Neuroimmunology and Neurodegeneration 2025
Aleksej Frolov, Hao Huang, Dagmar Schütz, Maren Köhne, Nelli Blank-Stein, Collins Osei-Sarpong, Maren Büttner, Tarek Elmzzahi, Mukhran Khundadze, Marina Zahid, Michael Reuter, Matthias Becker, Elena De Domenico, Lorenzo Bonaguro, Axel Kallies, Helen Morrison, Christian A. Hübner, Kristian Händler, Ralf Stumm, Elvira Mass, Marc D. Beyer
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20232357.
https://doi.org/10.1084/jem.20232357
Published: 23 April 2025
View article titled, Microglia and CD8+ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15
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Includes: Supplementary data
Journal Articles

Microbiota-centered interventions to boost immune checkpoint blockade therapies

In Special Collection:
JEM Clinical Immunology Collection 2025
Andrew A. Almonte, Simon Thomas, Laurence Zitvogel
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2025) 222 (7): e20250378.
https://doi.org/10.1084/jem.20250378
Published: 22 April 2025
View article titled, Microbiota-centered interventions to boost immune checkpoint blockade therapies
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