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Journal Articles

Claudin 1–mediated positioning of DC1 to mTECs is essential for maintenance of central tolerance

Jiří Březina, Tomáš Brabec, David Machač, Matouš Vobořil, Ondřej Ballek, Jan Pačes, Vojtěch Sýkora, Kristína Jančovičová, Evgeny Valter, Katarína Kováčová, Jasper Manning, Valerie Tahtahová, Adéla Čepková, Martina Dobešová, Jan Dobeš, Jan Kubovčiak, Michal Kolář, Petr Kašpárek, Radislav Sedlacek, Ondřej Štepánek, Jan Černý, Sachiko Tsukita, Bernard Malissen, Graham Anderson, Dominik Filipp
Journal: Journal of Experimental Medicine
J Exp Med (2026) 223 (3): e20250970.
https://doi.org/10.1084/jem.20250970
Published: 02 January 2026
View article titled, Claudin 1–mediated positioning of DC1 to mTECs is essential for maintenance of central tolerance
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Includes: Supplementary data
Journal Articles

Bringing natural killer cells to the clinic: Opportunities beyond cancer

Marjorie Cayatte, Valentin Picant, Marie Vétizou, Eric Vivier
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20250612.
https://doi.org/10.1084/jem.20250612
Published: 17 December 2025
View article titled, Bringing natural killer cells to the clinic: Opportunities beyond cancer
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Journal Articles

REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis

Xianting Hu, Zhi Liu, Yao Li, Yannan You, Kaiye Yue, Yuqiong Liang, Chin-San Loo, Jingting Yu, Matthias Leblanc, Dehui Wang, Huabin Li, Ye Zheng
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (2): e20241463.
https://doi.org/10.1084/jem.20241463
Published: 08 December 2025
View article titled, REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis
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Includes: Supplementary data
Journal Articles

Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis

Adrian Gervais, Astrid Marchal, Soraya Boucherit, Anthony Abi Haidar, Lucy Bizien, Ahmet Yalcinkaya, Ella Sandström, Xiao-Fei Kong, Emmanuel Jacquemin, Olivier Bernard, Dominique Debray, Florence Lacaille, Philippe Ichai, Cigdem Arikan, Etienne Javouhey, Bertrand Roquelaure, Frédéric Gottrand, Francesca Trespidi, Veronica Codullo, Lorenzo Cavagna, Nicolas Schleinitz, Mohamed Bousfiha, Naima Amenzoui, Ahmed Aziz Bousfiha, Sofie E. Jørgensen, Nanna Mørk, Trine H. Mogensen, Paul Bastard, Anne Puel, Alessandro Borghesi, Jody A. Rule, William M. Lee, Nils Landegren, Aurélie Cobat, Jean-Laurent Casanova, Emmanuelle Jouanguy
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (3): e20251760.
https://doi.org/10.1084/jem.20251760
Published: 05 December 2025
View article titled, Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis
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Journal Articles

SpeckSeq enables high-throughput functional stratification of MEFV variants in autoinflammatory diseases

Pauline Bronnec, Sarah Dalmon, Chloe Briand, Omran Allatif, Martin Broly, Melissa Marcotte, Gianluca Lombardi, Kevin Barthes, Nora Martel, Sandrine Hughes, Benjamin Gillet, Florian Milhavet, Aysima Atilgan, Hervé Bachelez, Serena Palmeri, Ignazia Prigione, Marine Madrange, Léa Savey, Michel Moutschen, Isabelle Jeru, Majdouline El Moussaoui, Alexandre Belot, Emilie Sbidian, Alessandra Carbone, Yvan Jamilloux, Marco Gattorno, Asma Smahi, Sophie Georgin-Lavialle, Guilaine Boursier, Flora Magnotti, Thomas Henry
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (2): e20251065.
https://doi.org/10.1084/jem.20251065
Published: 03 December 2025
View article titled, SpeckSeq enables high-throughput functional stratification of MEFV variants in autoinflammatory diseases
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Includes: Supplementary data
Journal Articles

Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance

In Special Collection:
2025 Nobel Prize Collection
Masaya Arai, Ryoji Kawakami, Yamami Nakamura, Yoko Naito, Daisuke Motooka, Atsushi Sugimoto, Tomiko Kimoto, Naganari Ohkura, Norihisa Mikami, Shimon Sakaguchi
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (3): e20251635.
https://doi.org/10.1084/jem.20251635
Published: 21 October 2025
View article titled, Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance
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Includes: Supplementary data
Journal Articles

Dynamic alterations of dural and bone marrow B cells in an animal model of progressive multiple sclerosis

In Special Collection:
Neuroscience Collection 2025
Alexandra Florescu, Michelle Zuo, Angela A. Wang, Kevin Champagne-Jorgensen, Mohammed A. Noor, Lesley A. Ward, Erwin van Puijenbroek, Christian Klein, Jennifer L. Gommerman
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (12): e20241255.
https://doi.org/10.1084/jem.20241255
Published: 18 September 2025
View article titled, Dynamic alterations of dural and bone marrow B cells in an animal model of progressive multiple sclerosis
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Includes: Supplementary data
Journal Articles

Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation

Jinjin Xu, Lingjia Kong, Elizabeth A. Creasey, Sneha Rath, Lei Deng, Julian Avila-Pacheco, Chenhao Li, Blayne A. Oliver, Tyler T. Dao, Angela R. Shih, Mark J. Daly, Alex K. Shalek, Clary B. Clish, Daniel B. Graham, Jacques Deguine, Ramnik J. Xavier
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20250185.
https://doi.org/10.1084/jem.20250185
Published: 11 September 2025
View article titled, Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation
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Includes: Supplementary data
Journal Articles

A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritis

Paul J. Hoover, Chirag Raparia, David J. Lieb, Yochay Tzur, Joyce Kang, Arnon Arazi, Rollin Leavitt, Rakesh Mishra, Sujal I. Shah, Daimon Simmons, Stephen Li, Michael Peters, Thomas Eisenhaure, Timothy J. Few-Cooper, Saisram S. Gurajala, Abraham Sonny, Jeffrey B. Hodgin, Celine C. Berthier, Joel M. Guthridge, Andrea Fava, Robert M. Clancy, Chaim Putterman, Peter M. Izmirly, H. Michael Belmont, Kenneth Kalunian, Diane Kamen, David Wofsy, Jill P. Buyon, Judith A. James, Michelle Petri, Betty Diamond, Soumya Raychaudhuri, Shai S. Shen-Orr, Accelerating Medicines Partnership in RA/SLE network, Nir Hacohen, Anne Davidson
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20241873.
https://doi.org/10.1084/jem.20241873
Published: 03 September 2025
View article titled, A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritis
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Includes: Supplementary data
Journal Articles

Dadaism catches up with DADA2

Dusan Bogunovic
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20251490.
https://doi.org/10.1084/jem.20251490
Published: 27 August 2025
View article titled, Dadaism catches up with DADA2
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Journal Articles

Dominant negative ADA2 mutations cause ADA2 deficiency in heterozygous carriers

In Special Collection:
Pattern Recognition Receptors and Beyond , 2025: The Year in Experimental Medicine
Marjon Wouters, Lisa Ehlers, Wout Van Eynde, Meltem Ece Kars, Selket Delafontaine, Verena Kienapfel, Mariia Dzhus, Rik Schrijvers, Petra De Haes, Sofie Struyf, Giorgia Bucciol, Yuval Itan, Alexandre Bolze, Arnout Voet, Anneleen Hombrouck, Leen Moens, Benson Ogunjimi, Isabelle Meyts
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20250499.
https://doi.org/10.1084/jem.20250499
Published: 27 August 2025
View article titled, Dominant negative ADA2 mutations cause ADA2 deficiency in heterozygous carriers
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Includes: Supplementary data
Journal Articles

Adipose tissue harbors pathogenic T cells in obesity that exacerbate inflammatory arthritis

In Special Collection:
Cytokines Collection 2025
Heather J. Faust, Margaret H. Chang, A. Helena Jonsson, Erin Theisen, Nelson M. LaMarche, William V. Trim, Lydia Lynch, Peter A. Nigrovic, Michael B. Brenner
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20240677.
https://doi.org/10.1084/jem.20240677
Published: 07 July 2025
View article titled, Adipose tissue harbors pathogenic T cells in obesity that exacerbate inflammatory arthritis
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Includes: Supplementary data
Journal Articles

IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints

Adam J. Fike, Kristen N. Bricker, Michael V. Gonzalez, Anju Maharjan, Tien Bui, Keomonyroth Nuon, Scott M. Emrich, Julia L. Weber, Sara A. Luckenbill, Nicholas M. Choi, Renan Sauteraud, Dajiang J. Liu, Nancy J. Olsen, Roberto Caricchio, Mohamed Trebak, Sathi Babu Chodisetti, Ziaur S.M. Rahman
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20231882.
https://doi.org/10.1084/jem.20231882
Published: 29 May 2025
View article titled, IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints
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Journal Articles

Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFNα

Artur Stoljar, Maksym Zarodniuk, Rudolf Bichele, Elise Helene Armulik, Uku Haljasorg, Romain Humeau, Marine Besnard, Liis Haljasmägi, Liina Tserel, Merili Peltser, Ahto Salumets, Eliisa Kekäläinen, Kai Kisand, Carole Guillonneau, Martti Laan, Pärt Peterson
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20241403.
https://doi.org/10.1084/jem.20241403
Published: 30 April 2025
View article titled, Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFNα
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Includes: Supplementary data
Journal Articles

Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity

In Special Collection:
Neuroimmunology and Neurodegeneration 2025
Nicolas Fonta, Nicolas Page, Bogna Klimek, Margot Piccinno, Giovanni Di Liberto, Sylvain Lemeille, Mario Kreutzfeldt, Anna Lena Kastner, Yusuf I. Ertuna, Ilena Vincenti, Ingrid Wagner, Daniel D. Pinschewer, Doron Merkler
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20241188.
https://doi.org/10.1084/jem.20241188
Published: 14 April 2025
View article titled, Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity
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Includes: Supplementary data
Journal Articles

Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design

In Special Collection:
2025: The Year in Experimental Medicine
Kevin Groen, Roger Kuratli, Jannik Enkelmann, Sonja Fernbach, Pedro D. Wendel-Garcia, Willy I. Staiger, Marylène Lejeune, Esther Sauras-Colón, Ferran Roche-Campo, Paraskevas Filippidis, Andri Rauch, Swiss HIV Cohort Study, Alexandra Trkola, Huldrych F. Günthard, Roger D. Kouyos, Silvio D. Brugger, Benjamin G. Hale
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20242039.
https://doi.org/10.1084/jem.20242039
Published: 20 March 2025
View article titled, Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design
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Includes: Supplementary data
Journal Articles

The common HAQ STING allele prevents clinical penetrance of COPA syndrome

In Special Collection:
Genes and Immunity
Noa Simchoni, Shogo Koide, Maryel Likhite, Yoshihiko Kuchitsu, Senkottuvelan Kadirvel, Christopher S. Law, Brett M. Elicker, Santosh Kurra, Margaret Mei-Kay Wong, Bo Yuan, Alice Grossi, Ronald M. Laxer, Stefano Volpi, Dilan Dissanayake, Tomohiko Taguchi, David B. Beck, Tiphanie P. Vogel, Anthony K. Shum
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e20242179.
https://doi.org/10.1084/jem.20242179
Published: 27 February 2025
View article titled, The common HAQ STING allele prevents clinical penetrance of COPA syndrome
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Includes: Supplementary data
Journal Articles

PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease

In Special Collection:
JEM Immunology Collection 2025 , JEM Clinical Immunology Collection 2025
Devon Jeltema, Kennady Knox, Nicole Dobbs, Zhen Tang, Cong Xing, Antonina Araskiewicz, Kun Yang, Ivan Rodriguez Siordia, Jason Matthews, Michael Cohen, Nan Yan
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20241184.
https://doi.org/10.1084/jem.20241184
Published: 19 February 2025
View article titled, PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease
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Includes: Supplementary data
Journal Articles

pDCs, type 1 IFN, and the female predileXion of SSc

Nikhil Jiwrajka, Montserrat C. Anguera
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (3): e20242284.
https://doi.org/10.1084/jem.20242284
Published: 17 January 2025
View article titled, pDCs, type 1 IFN, and the female predileXion of SSc
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Journal Articles

Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans

In Special Collection:
Genes and Immunity
Quentin Riller, Boris Sorin, Charline Courteille, Duong Ho-Nhat, Tom Le Voyer, Jean-Christophe Debray, Marie-Claude Stolzenberg, Muriel Schmutz, Olivier Pellé, Thomas Becquard, María Rodrigo Riestra, Laureline Berteloot, Mélanie Migaud, Laure Delage, Marie Jeanpierre, Charlotte Boussard, Camille Brunaud, Aude Magérus, Charles Bretot, Victor Michel, Camille Roux, Capucine Picard, Cécile Masson, Christine Bole-Feysot, Nicolas Cagnard, Aurélien Corneau, Isabelle Meyts, Véronique Baud, Jean-Laurent Casanova, Alain Fischer, Emmanuel Dejardin, Anne Puel, Cécile Boulanger, Bénédicte Neven, Frédéric Rieux-Laucat
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (2): e20240843.
https://doi.org/10.1084/jem.20240843
Published: 15 January 2025
View article titled, Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans
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Includes: Supplementary data