1-20 of 271
Autoimmunity
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance

Masaya Arai, Ryoji Kawakami, Yamami Nakamura, Yoko Naito, Daisuke Motooka, Atsushi Sugimoto, Tomiko Kimoto, Naganari Ohkura, Norihisa Mikami, Shimon Sakaguchi
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (3): e20251635.
https://doi.org/10.1084/jem.20251635
Published: 21 October 2025
View article titled, Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance
Open the PDF for Oral antigen exposure under costimulation blockade induces Treg cells to establish immune tolerance in another window
Includes: Supplementary data
Journal Articles

Dynamic alterations of dural and bone marrow B cells in an animal model of progressive multiple sclerosis

In Special Collection:
Neuroscience Collection 2025
Alexandra Florescu, Michelle Zuo, Angela A. Wang, Kevin Champagne-Jorgensen, Mohammed A. Noor, Lesley A. Ward, Erwin van Puijenbroek, Christian Klein, Jennifer L. Gommerman
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (12): e20241255.
https://doi.org/10.1084/jem.20241255
Published: 18 September 2025
View article titled, Dynamic alterations of dural and bone marrow B cells in an animal model of progressive multiple sclerosis
Open the PDF for Dynamic alterations of dural and bone marrow B cells in an animal model of progressive multiple sclerosis in another window
Includes: Supplementary data
Journal Articles

Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation

Jinjin Xu, Lingjia Kong, Elizabeth A. Creasey, Sneha Rath, Lei Deng, Julian Avila-Pacheco, Chenhao Li, Blayne A. Oliver, Tyler T. Dao, Angela R. Shih, Mark J. Daly, Alex K. Shalek, Clary B. Clish, Daniel B. Graham, Jacques Deguine, Ramnik J. Xavier
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20250185.
https://doi.org/10.1084/jem.20250185
Published: 11 September 2025
View article titled, Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation
Open the PDF for Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation in another window
Includes: Supplementary data
Journal Articles

A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritis

Paul J. Hoover, Chirag Raparia, David J. Lieb, Yochay Tzur, Joyce Kang, Arnon Arazi, Rollin Leavitt, Rakesh Mishra, Sujal I. Shah, Daimon Simmons, Stephen Li, Michael Peters, Thomas Eisenhaure, Timothy J. Few-Cooper, Saisram S. Gurajala, Abraham Sonny, Jeffrey B. Hodgin, Celine C. Berthier, Joel M. Guthridge, Andrea Fava, Robert M. Clancy, Chaim Putterman, Peter M. Izmirly, H. Michael Belmont, Kenneth Kalunian, Diane Kamen, David Wofsy, Jill P. Buyon, Judith A. James, Michelle Petri, Betty Diamond, Soumya Raychaudhuri, Shai S. Shen-Orr, Accelerating Medicines Partnership in RA/SLE network, Nir Hacohen, Anne Davidson
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20241873.
https://doi.org/10.1084/jem.20241873
Published: 03 September 2025
View article titled, A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritis
Open the PDF for A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritis in another window
Includes: Supplementary data
Journal Articles

Dadaism catches up with DADA2

Dusan Bogunovic
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20251490.
https://doi.org/10.1084/jem.20251490
Published: 27 August 2025
View article titled, Dadaism catches up with DADA2
Open the PDF for Dadaism catches up with DADA2 in another window
Journal Articles

Dominant negative ADA2 mutations cause ADA2 deficiency in heterozygous carriers

In Special Collection:
Pattern Recognition Receptors and Beyond
Marjon Wouters, Lisa Ehlers, Wout Van Eynde, Meltem Ece Kars, Selket Delafontaine, Verena Kienapfel, Mariia Dzhus, Rik Schrijvers, Petra De Haes, Sofie Struyf, Giorgia Bucciol, Yuval Itan, Alexandre Bolze, Arnout Voet, Anneleen Hombrouck, Leen Moens, Benson Ogunjimi, Isabelle Meyts
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (11): e20250499.
https://doi.org/10.1084/jem.20250499
Published: 27 August 2025
View article titled, Dominant negative ADA2 mutations cause ADA2 deficiency in heterozygous carriers
Open the PDF for Dominant negative ADA2 mutations cause ADA2 deficiency in heterozygous carriers in another window
Includes: Supplementary data
Journal Articles

Adipose tissue harbors pathogenic T cells in obesity that exacerbate inflammatory arthritis

In Special Collection:
Cytokines Collection 2025
Heather J. Faust, Margaret H. Chang, A. Helena Jonsson, Erin Theisen, Nelson M. LaMarche, William V. Trim, Lydia Lynch, Peter A. Nigrovic, Michael B. Brenner
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (9): e20240677.
https://doi.org/10.1084/jem.20240677
Published: 07 July 2025
View article titled, Adipose tissue harbors pathogenic T cells in obesity that exacerbate inflammatory arthritis
Open the PDF for Adipose tissue harbors pathogenic T cells in obesity that exacerbate inflammatory arthritis in another window
Includes: Supplementary data
Journal Articles

IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints

Adam J. Fike, Kristen N. Bricker, Michael V. Gonzalez, Anju Maharjan, Tien Bui, Keomonyroth Nuon, Scott M. Emrich, Julia L. Weber, Sara A. Luckenbill, Nicholas M. Choi, Renan Sauteraud, Dajiang J. Liu, Nancy J. Olsen, Roberto Caricchio, Mohamed Trebak, Sathi Babu Chodisetti, Ziaur S.M. Rahman
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20231882.
https://doi.org/10.1084/jem.20231882
Published: 29 May 2025
View article titled, IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints
Open the PDF for IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints in another window
Journal Articles

Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFNα

Artur Stoljar, Maksym Zarodniuk, Rudolf Bichele, Elise Helene Armulik, Uku Haljasorg, Romain Humeau, Marine Besnard, Liis Haljasmägi, Liina Tserel, Merili Peltser, Ahto Salumets, Eliisa Kekäläinen, Kai Kisand, Carole Guillonneau, Martti Laan, Pärt Peterson
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20241403.
https://doi.org/10.1084/jem.20241403
Published: 30 April 2025
View article titled, Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFNα
Open the PDF for Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFNα in another window
Includes: Supplementary data
Journal Articles

Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity

In Special Collection:
Neuroimmunology and Neurodegeneration 2025
Nicolas Fonta, Nicolas Page, Bogna Klimek, Margot Piccinno, Giovanni Di Liberto, Sylvain Lemeille, Mario Kreutzfeldt, Anna Lena Kastner, Yusuf I. Ertuna, Ilena Vincenti, Ingrid Wagner, Daniel D. Pinschewer, Doron Merkler
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20241188.
https://doi.org/10.1084/jem.20241188
Published: 14 April 2025
View article titled, Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity
Open the PDF for Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity in another window
Includes: Supplementary data
Journal Articles

Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design

Kevin Groen, Roger Kuratli, Jannik Enkelmann, Sonja Fernbach, Pedro D. Wendel-Garcia, Willy I. Staiger, Marylène Lejeune, Esther Sauras-Colón, Ferran Roche-Campo, Paraskevas Filippidis, Andri Rauch, Swiss HIV Cohort Study, Alexandra Trkola, Huldrych F. Günthard, Roger D. Kouyos, Silvio D. Brugger, Benjamin G. Hale
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (6): e20242039.
https://doi.org/10.1084/jem.20242039
Published: 20 March 2025
View article titled, Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design
Open the PDF for Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design in another window
Includes: Supplementary data
Journal Articles

The common HAQ STING allele prevents clinical penetrance of COPA syndrome

In Special Collection:
Genes and Immunity
Noa Simchoni, Shogo Koide, Maryel Likhite, Yoshihiko Kuchitsu, Senkottuvelan Kadirvel, Christopher S. Law, Brett M. Elicker, Santosh Kurra, Margaret Mei-Kay Wong, Bo Yuan, Alice Grossi, Ronald M. Laxer, Stefano Volpi, Dilan Dissanayake, Tomohiko Taguchi, David B. Beck, Tiphanie P. Vogel, Anthony K. Shum
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (4): e20242179.
https://doi.org/10.1084/jem.20242179
Published: 27 February 2025
View article titled, The common HAQ STING allele prevents clinical penetrance of COPA syndrome
Open the PDF for The common HAQ STING allele prevents clinical penetrance of COPA syndrome in another window
Includes: Supplementary data
Journal Articles

PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease

In Special Collection:
JEM Immunology Collection 2025 , JEM Clinical Immunology Collection 2025
Devon Jeltema, Kennady Knox, Nicole Dobbs, Zhen Tang, Cong Xing, Antonina Araskiewicz, Kun Yang, Ivan Rodriguez Siordia, Jason Matthews, Michael Cohen, Nan Yan
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (5): e20241184.
https://doi.org/10.1084/jem.20241184
Published: 19 February 2025
View article titled, PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease
Open the PDF for PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease in another window
Includes: Supplementary data
Journal Articles

pDCs, type 1 IFN, and the female predileXion of SSc

Nikhil Jiwrajka, Montserrat C. Anguera
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (3): e20242284.
https://doi.org/10.1084/jem.20242284
Published: 17 January 2025
View article titled, pDCs, type 1 IFN, and the female predileXion of SSc
Open the PDF for pDCs, type 1 IFN, and the female predileXion of SSc in another window
Journal Articles

Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans

In Special Collection:
Genes and Immunity
Quentin Riller, Boris Sorin, Charline Courteille, Duong Ho-Nhat, Tom Le Voyer, Jean-Christophe Debray, Marie-Claude Stolzenberg, Muriel Schmutz, Olivier Pellé, Thomas Becquard, María Rodrigo Riestra, Laureline Berteloot, Mélanie Migaud, Laure Delage, Marie Jeanpierre, Charlotte Boussard, Camille Brunaud, Aude Magérus, Charles Bretot, Victor Michel, Camille Roux, Capucine Picard, Cécile Masson, Christine Bole-Feysot, Nicolas Cagnard, Aurélien Corneau, Isabelle Meyts, Véronique Baud, Jean-Laurent Casanova, Alain Fischer, Emmanuel Dejardin, Anne Puel, Cécile Boulanger, Bénédicte Neven, Frédéric Rieux-Laucat
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (2): e20240843.
https://doi.org/10.1084/jem.20240843
Published: 15 January 2025
View article titled, Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans
Open the PDF for Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans in another window
Includes: Supplementary data
Journal Articles

The phospholipid kinase PIKFYVE is essential for Th17 differentiation

Douglas S. Prado, Richard T. Cattley, Andreza B. Sonego, Parth Sutariya, Shuxian Wu, Mijoon Lee, William C. Boggess, Mark J. Shlomchik, William F. Hawse
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (2): e20240625.
https://doi.org/10.1084/jem.20240625
Published: 31 December 2024
View article titled, The phospholipid kinase PIKFYVE is essential for Th17 differentiation
Open the PDF for The phospholipid kinase PIKFYVE is essential for Th17 differentiation in another window
Includes: Supplementary data
Journal Articles

Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis

In Special Collection:
JEM Clinical Immunology Collection 2025
Yong Du, Bérénice Faz-Lopez, Marie Dominique Ah Kioon, Claire Cenac, Michael Pierides, Kimberly S. Lakin, Robert F. Spiera, Julie Chaumeil, Marie-Elise Truchetet, Jessica K. Gordon, Jean-Charles Guéry, Franck J. Barrat
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (3): e20231809.
https://doi.org/10.1084/jem.20231809
Published: 13 December 2024
View article titled, Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis
Open the PDF for Altered X-chromosome inactivation of the TLR7/8 locus and heterogeneity of pDCs in systemic sclerosis in another window
Includes: Supplementary data
Journal Articles

Antiviral immunity lassoed down by excess RNA

Erika Valeri, Anna Kajaste-Rudnitski
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (1): e20241743.
https://doi.org/10.1084/jem.20241743
Published: 06 December 2024
View article titled, Antiviral immunity lassoed down by excess RNA
Open the PDF for Antiviral immunity lassoed down by excess RNA in another window
Journal Articles

The brain–eye connection: More than just action potentials

James Walsh
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20241519.
https://doi.org/10.1084/jem.20241519
Published: 10 October 2024
View article titled, The brain–eye connection: More than just action potentials
Open the PDF for The brain–eye connection: More than just action potentials in another window
Journal Articles

Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseases

Jérémie Rosain, Tom Le Voyer, Xian Liu, Adrian Gervais, Laura Polivka, Axel Cederholm, Laureline Berteloot, Audrey V. Parent, Alessandra Pescatore, Ezia Spinosa, Snezana Minic, Ana Elisa Kiszewski, Miyuki Tsumura, Chloé Thibault, Maria Esnaola Azcoiti, Jelena Martinovic, Quentin Philippot, Taushif Khan, Astrid Marchal, Bénédicte Charmeteau-De Muylder, Lucy Bizien, Caroline Deswarte, Lillia Hadjem, Marie-Odile Fauvarque, Karim Dorgham, Daniel Eriksson, Emilia Liana Falcone, Mathilde Puel, Sinem Ünal, Amyrath Geraldo, Corentin Le Floc’h, Hailun Li, Sylvie Rheault, Christine Muti, Claire Bobrie-Moyrand, Anne Welfringer-Morin, Ramsay L. Fuleihan, Romain Lévy, Marie Roelens, Liwei Gao, Marie Materna, Silvia Pellegrini, Lorenzo Piemonti, Emilie Catherinot, Jean-Christophe Goffard, Arnaud Fekkar, Aissata Sacko-Sow, Camille Soudée, Soraya Boucherit, Anna-Lena Neehus, Cristina Has, Stefanie Hübner, Géraldine Blanchard-Rohner, Blanca Amador-Borrero, Takanori Utsumi, Maki Taniguchi, Hiroo Tani, Kazushi Izawa, Takahiro Yasumi, Sotaro Kanai, Mélanie Migaud, Mélodie Aubart, Nathalie Lambert, Guy Gorochov, Capucine Picard, Claire Soudais, Anne-Sophie L’Honneur, Flore Rozenberg, Joshua D. Milner, Shen-Ying Zhang, Pierre Vabres, Dusan Trpinac, Nico Marr, Nathalie Boddaert, Isabelle Desguerre, Manolis Pasparakis, Corey N. Miller, Cláudia S. Poziomczyk, Laurent Abel, Satoshi Okada, Emmanuelle Jouanguy, Rémi Cheynier, Qian Zhang, Aurélie Cobat, Vivien Béziat, Bertrand Boisson, Julie Steffann, Francesca Fusco, Matilde Valeria Ursini, Smail Hadj-Rabia, Christine Bodemer, Jacinta Bustamante, Hervé Luche, Anne Puel, Gilles Courtois, Paul Bastard, Nils Landegren, Mark S. Anderson, Jean-Laurent Casanova
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20231152.
https://doi.org/10.1084/jem.20231152
Published: 01 October 2024
View article titled, Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseases
Open the PDF for Incontinentia pigmenti underlies thymic dysplasia, autoantibodies to type I IFNs, and viral diseases in another window
Includes: Supplementary data