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Journal Articles

Framework for in vivo T cell screens

Lauren E. Milling, Samuel C. Markson, Qin Tjokrosurjo, Nicole M. Derosia, Ivy S.L. Streeter, Grant H. Hickok, Ashlyn M. Lemmen, Thao H. Nguyen, Priyamvada Prathima, William Fithian, Marc A. Schwartz, Nir Hacohen, John G. Doench, Martin W. LaFleur, Arlene H. Sharpe

J Exp Med (2024) 221 (4): e20230699.

https://doi.org/10.1084/jem.20230699

Published: 27 February 2024

View articletitled, Framework for in vivo T cell screens

Includes: Supplementary data

Journal Articles

Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice

Jenna L. Collier, Kristen E. Pauken, Catherine A.A. Lee, Dillon G. Patterson, Samuel C. Markson, Thomas S. Conway, Megan E. Fung, Joshua A. France, Kyla N. Mucciarone, Christine G. Lian, George F. Murphy, Arlene H. Sharpe

J Exp Med (2023) 220 (10): e20221920.

https://doi.org/10.1084/jem.20221920

Published: 11 July 2023

View articletitled, Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice

Includes: Supplementary data

Journal Articles

Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment

In Special Collection:

2022 Clinical Collection on Cancer , JEM Cancer Immunotherapy 2021 , JEM Clinical Immunology Collection 2021

J Exp Med (2021) 218 (4): e20200920.

https://doi.org/10.1084/jem.20200920

Published: 02 March 2021

View articletitled, Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment

Includes: Supplementary data

Journal Articles

Understanding adverse events of immunotherapy: A mechanistic perspective

In Special Collection:

2022 Clinical Collection on Cancer , JEM Cancer Immunotherapy 2021

Kelly P. Burke, Stephanie Grebinoski, Arlene H. Sharpe, Dario A.A. Vignali

J Exp Med (2020) 218 (1): e20192179.

https://doi.org/10.1084/jem.20192179

Published: 18 December 2020

View articletitled, Understanding adverse events of immunotherapy: A mechanistic perspective

Journal Articles

PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

In Special Collection:

JEM Cancer Collection 2021

Catherine L. Tan, Juhi R. Kuchroo, Peter T. Sage, Dan Liang, Loise M. Francisco, Jessica Buck, Youg Raj Thaker, Qianxia Zhang, Shannon L. McArdel, Vikram R. Juneja, Sun Jung Lee, Scott B. Lovitch, Christine Lian, George F. Murphy, Bruce R. Blazar, Dario A.A. Vignali, Gordon J. Freeman, Arlene H. Sharpe

J Exp Med (2020) 218 (1): e20182232.

https://doi.org/10.1084/jem.20182232

Published: 06 October 2020

View articletitled, PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

Includes: Supplementary data

Journal Articles

FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program

In Special Collection:

B Cells, T Cells, Vaccines 2019

Shenda Hou, Rachel L. Clement, Alos Diallo, Bruce R. Blazar, Alexander Y. Rudensky, Arlene H. Sharpe, Peter T. Sage

J Exp Med (2019) 216 (3): 605–620.

https://doi.org/10.1084/jem.20181134

Published: 31 January 2019

View articletitled, FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program

Includes: Supplementary data

Journal Articles

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity

In Special Collection:

Cancer and Autoimmunity , Lymphocytes and their Roles in Cancer , T Cell Dysfunction, Cancer, and Infection

Vikram R. Juneja, Kathleen A. McGuire, Robert T. Manguso, Martin W. LaFleur, Natalie Collins, W. Nicholas Haining, Gordon J. Freeman, Arlene H. Sharpe

J Exp Med (2017) 214 (4): 895–904.

https://doi.org/10.1084/jem.20160801

Published: 16 March 2017

View articletitled, PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity

Journal Articles

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

Alison M. Paterson, Scott B. Lovitch, Peter T. Sage, Vikram R. Juneja, Youjin Lee, Justin D. Trombley, Carolina V. Arancibia-Cárcamo, Raymond A. Sobel, Alexander Y. Rudensky, Vijay K. Kuchroo, Gordon J. Freeman, Arlene H. Sharpe

J Exp Med (2015) 212 (10): 1603–1621.

https://doi.org/10.1084/jem.20141030

Published: 14 September 2015

View articletitled, Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

Journal Articles

Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection

Pablo Penaloza-MacMaster, Alice O. Kamphorst, Andreas Wieland, Koichi Araki, Smita S. Iyer, Erin E. West, Leigh O’Mara, Shu Yang, Bogumila T. Konieczny, Arlene H. Sharpe, Gordon J. Freeman, Alexander Y. Rudensky, Rafi Ahmed

J Exp Med (2014) 211 (9): 1905–1918.

https://doi.org/10.1084/jem.20132577

Published: 11 August 2014

View articletitled, Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection

Journal Articles

RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance

Yanping Xiao, Sanhong Yu, Baogong Zhu, Denis Bedoret, Xia Bu, Loise M. Francisco, Ping Hua, Jonathan S. Duke-Cohan, Dale T. Umetsu, Arlene H. Sharpe, Rosemarie H. DeKruyff, Gordon J. Freeman

J Exp Med (2014) 211 (5): 943–959.

https://doi.org/10.1084/jem.20130790

Published: 21 April 2014

View articletitled, RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance

Journal Articles

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

Loise M. Francisco, Victor H. Salinas, Keturah E. Brown, Vijay K. Vanguri, Gordon J. Freeman, Vijay K. Kuchroo, Arlene H. Sharpe

J Exp Med (2009) 206 (13): 3015–3029.

https://doi.org/10.1084/jem.20090847

Published: 14 December 2009

View articletitled, PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

Includes: Multimedia, Supplementary data

Journal Articles

Enhancing therapeutic vaccination by blocking PD-1–mediated inhibitory signals during chronic infection

Sang-Jun Ha, Scott N. Mueller, E. John Wherry, Daniel L. Barber, Rachael D. Aubert, Arlene H. Sharpe, Gordon J. Freeman, Rafi Ahmed

J Exp Med (2008) 205 (3): 543–555.

https://doi.org/10.1084/jem.20071949

Published: 10 March 2008

View articletitled, Enhancing therapeutic vaccination by blocking PD-1–mediated inhibitory signals during chronic infection

Includes: Supplementary data

Journal Articles

Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

Gordon J. Freeman, E. John Wherry, Rafi Ahmed, Arlene H. Sharpe

J Exp Med (2006) 203 (10): 2223–2227.

https://doi.org/10.1084/jem.20061800

Published: 25 September 2006

View articletitled, Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

Journal Articles

Tissue expression of PD-L1 mediates peripheral T cell tolerance

Mary E. Keir, Spencer C. Liang, Indira Guleria, Yvette E. Latchman, Andi Qipo, Lee A. Albacker, Maria Koulmanda, Gordon J. Freeman, Mohamed H. Sayegh, Arlene H. Sharpe

J Exp Med (2006) 203 (4): 883–895.

https://doi.org/10.1084/jem.20051776

Published: 10 April 2006

View articletitled, Tissue expression of PD-L1 mediates peripheral T cell tolerance

Includes: Supplementary data

Journal Articles

The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions

Ninghai Wang, Abhay Satoskar, William Faubion, Duncan Howie, Susumu Okamoto, Stefan Feske, Charles Gullo, Kareem Clarke, Miriam Rodriguez Sosa, Arlene H. Sharpe, Cox Terhorst

J Exp Med (2004) 199 (9): 1255–1264.

https://doi.org/10.1084/jem.20031835

Published: 03 May 2004

View articletitled, The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions

Includes: Supplementary data

Journal Articles

Studies in B7-Deficient Mice Reveal a Critical Role for B7 Costimulation in Both Induction and Effector Phases of Experimental Autoimmune Encephalomyelitis

Tammy T. Chang, Claudia Jabs, Raymond A. Sobel, Vijay K. Kuchroo, Arlene H. Sharpe

J Exp Med (1999) 190 (5): 733–740.

https://doi.org/10.1084/jem.190.5.733

Published: 06 September 1999

View articletitled, Studies in B7-Deficient Mice Reveal a Critical Role for B7 Costimulation in Both Induction and Effector Phases of Experimental Autoimmune Encephalomyelitis

Journal Articles

B7-1 or B7-2 Is Required to Produce the Lymphoproliferative Phenotype in Mice Lacking Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4)

Didier A. Mandelbrot, Alexander J. McAdam, Arlene H. Sharpe

J Exp Med (1999) 189 (2): 435–440.

https://doi.org/10.1084/jem.189.2.435

Published: 18 January 1999

View articletitled, B7-1 or B7-2 Is Required to Produce the Lymphoproliferative Phenotype in Mice Lacking Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4)

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Framework for in vivo T cell screens

Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice

Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment

Understanding adverse events of immunotherapy: A mechanistic perspective

PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection

RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

Enhancing therapeutic vaccination by blocking PD-1–mediated inhibitory signals during chronic infection

Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

Tissue expression of PD-L1 mediates peripheral T cell tolerance

The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions

Studies in B7-Deficient Mice Reveal a Critical Role for B7 Costimulation in Both Induction and Effector Phases of Experimental Autoimmune Encephalomyelitis

B7-1 or B7-2 Is Required to Produce the Lymphoproliferative Phenotype in Mice Lacking Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4)

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