Issues

Cover picture: Ribbon diagram of the three-dimensional structure of the cysteine-rich domain of the mannose receptor (MR) complexed with a sulfated carbohydrate ligand. MR is a prototype member of a family of multilectin receptors that recognize carbohydrates on the cell walls of infectious organisms. The NH₂-terminal cysteine-rich domain (Cys-MR) binds to glycoproteins containing sulfated sugars, such as sulfated hormones, and to chondroitin sulfates A and B and sulfated oligosaccharides of the Lewis^a and Lewis^x types. See related articles in this issue by Liu et al., 1105-1115, and Leteux et al., 1117-1126.