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Volume 190, Issue 7
4 October 1999
Journal of Experimental Medicine Cover Image for Volume 190, Issue 7
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  • Cover Image

    Cover Image

    issue cover
    Cover picture: Immunofluorescence staining of IgA (green) and IgG (red) with blue nuclear staining in a cross-section of the crypt region from the small intestine of a polymeric Ig receptor knockout (pIgR-/-) mouse. Only the nuclei of the epithelial cells are seen because the (pIgR-/-) mice fail to actively transport IgA to the gut lumen (picture taken by Takeshi Yamanaka). See related article in this issue by Johansen et al., pp. 915­921.
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ISSN 0022-1007
EISSN 1540-9538
In this Issue

Commentary

Inhibition of Death Receptor Signaling by Flice-Inhibitory Protein as a Mechanism for Immune Escape of Tumors
Lars E. French,Jürg Tschopp
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Article

Crucial Role of the Interleukin 1 Receptor Family Member T1/St2 in T Helper Cell Type 2–Mediated Lung Mucosal Immune Responses
Anthony J. Coyle,Clare Lloyd,Jane Tian,Trang Nguyen,Christina Erikkson,Lin Wang,Par Ottoson,Per Persson,Tracy Delaney,Sophie Lehar,Steve Lin,Louis Poisson,Christian Meisel,Thomas Kamradt,Torbjorn Bjerke,Douglas Levinson,Jose Carlos Gutierrez-Ramos
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Selection at Multiple Checkpoints Focuses VH12 B Cell Differentiation toward a Single B-1 Cell Specificity
Calin Tatu,Jian Ye,Larry W. Arnold,Stephen H. Clarke
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Absence of Epithelial Immunoglobulin a Transport, with Increased Mucosal Leakiness, in Polymeric Immunoglobulin Receptor/Secretory Component–Deficient Mice
Finn-Eirik Johansen,Marcela Pekna,Inger Natvig Norderhaug,Bjørn Haneberg,Max Albert Hietala,Peter Krajci,Christer Betsholtz,Per Brandtzaeg
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Cytokine-Activated Endothelial Cells Delay Neutrophil Apoptosis in Vitro and in Vivo: A Role for Granulocyte/Macrophage Colony-Stimulating Factor
Angela Coxon,Tao Tang,Tanya N. Mayadas
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Sulfation of a High Endothelial Venule–Expressed Ligand for L-Selectin: Effects on Tethering and Rolling of Lymphocytes
Kirsten Tangemann,Annette Bistrup,Stefan Hemmerich,Steven D. Rosen
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Receptor Avidity and Costimulation Specify the Intracellular Ca2+ Signaling Pattern in Cd4+Cd8+ Thymocytes
Bruce D. Freedman,Qing-Hua Liu,Selin Somersan,Michael I. Kotlikoff,Jennifer A. Punt
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Tumor Necrosis Factor α Is a Critical Component of Interleukin 13–Mediated Protective T Helper Cell Type 2 Responses during Helminth Infection
David Artis,Neil E. Humphreys,Allison J. Bancroft,Nancy J. Rothwell,Christopher S. Potten,Richard K. Grencis
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A Defect in Interleukin 12–Induced Activation and Interferon γ Secretion of Peripheral Natural Killer T Cells in Nonobese Diabetic Mice Suggests New Pathogenic Mechanisms for Insulin-Dependent Diabetes Mellitus
Marika Falcone,Brian Yeung,Lee Tucker,Enrique Rodriguez,Nora Sarvetnick
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Defective Development of γ/δ T Cells in Interleukin 7 Receptor–Deficient Mice Is Due to Impaired Expression of T Cell Receptor γ Genes
Joonsoo Kang,Mark Coles,David H. Raulet
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The Stimulation of Low-Affinity, Nontolerized Clones by Heteroclitic Antigen Analogues Causes the Breaking of Tolerance Established to an Immunodominant T Cell Epitope
Rongfang Wang,Yiran Wang-Zhu,Claudia Raja Gabaglia,Kazuhiko Kimachi,Howard M. Grey
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An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation
Chrystelle Asseman,Smita Mauze,Michael W. Leach,Robert L. Coffman,Fiona Powrie
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Inhibitory Receptors Alter Natural Killer Cell Interactions with Target Cells Yet Allow Simultaneous Killing of Susceptible Targets
Mikael Eriksson,Guenther Leitz,Erik Fällman,Ove Axner,James C. Ryan,Mary C. Nakamura,Charles L. Sentman
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Interleukin 2, but Not Other Common γ Chain–Binding Cytokines, Can Reverse the Defect in Generation of Cd4 Effector T Cells from Naive T Cells of Aged Mice
Laura Haynes,Phyllis-Jean Linton,Sheri M. Eaton,Susan L. Tonkonogy,Susan L. Swain
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The Inhibitor of Death Receptor Signaling, Flice-Inhibitory Protein Defines a New Class of Tumor Progression Factors
Mounira Djerbi,Valentina Screpanti,Anca Irinel Catrina,Bjarne Bogen,Peter Biberfeld,Alf Grandien
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Brief Definitive Report

Immune Escape of Tumors in Vivo by Expression of Cellular Flice-Inhibitory Protein
Jan Paul Medema,Joan de Jong,Thorbald van Hall,Cornelis J.M. Melief,Rienk Offringa
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