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Volume 190, Issue 7
4 October 1999
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    Cover Image

    issue cover
    Cover picture: Immunofluorescence staining of IgA (green) and IgG (red) with blue nuclear staining in a cross-section of the crypt region from the small intestine of a polymeric Ig receptor knockout (pIgR-/-) mouse. Only the nuclei of the epithelial cells are seen because the (pIgR-/-) mice fail to actively transport IgA to the gut lumen (picture taken by Takeshi Yamanaka). See related article in this issue by Johansen et al., pp. 915­921.
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ISSN 0022-1007
EISSN 1540-9538
In this Issue

Commentary

Inhibition of Death Receptor Signaling by Flice-Inhibitory Protein as a Mechanism for Immune Escape of Tumors
Lars E. French,Jürg Tschopp
View Articletitled, Inhibition of Death Receptor Signaling by Flice-Inhibitory Protein as a Mechanism for Immune Escape of Tumors

Article

Crucial Role of the Interleukin 1 Receptor Family Member T1/St2 in T Helper Cell Type 2–Mediated Lung Mucosal Immune Responses
Anthony J. Coyle,Clare Lloyd,Jane Tian,Trang Nguyen,Christina Erikkson,Lin Wang,Par Ottoson,Per Persson,Tracy Delaney,Sophie Lehar,Steve Lin,Louis Poisson,Christian Meisel,Thomas Kamradt,Torbjorn Bjerke,Douglas Levinson,Jose Carlos Gutierrez-Ramos
View Articletitled, Crucial Role of the Interleukin 1 Receptor Family Member T1/St2 in T Helper Cell Type 2–Mediated Lung Mucosal Immune Responses
Selection at Multiple Checkpoints Focuses VH12 B Cell Differentiation toward a Single B-1 Cell Specificity
Calin Tatu,Jian Ye,Larry W. Arnold,Stephen H. Clarke
View Articletitled, Selection at Multiple Checkpoints Focuses V<sub>H</sub>12 B Cell Differentiation toward a Single B-1 Cell Specificity
Absence of Epithelial Immunoglobulin a Transport, with Increased Mucosal Leakiness, in Polymeric Immunoglobulin Receptor/Secretory Component–Deficient Mice
Finn-Eirik Johansen,Marcela Pekna,Inger Natvig Norderhaug,Bjørn Haneberg,Max Albert Hietala,Peter Krajci,Christer Betsholtz,Per Brandtzaeg
View Articletitled, Absence of Epithelial Immunoglobulin a Transport, with Increased Mucosal Leakiness, in Polymeric Immunoglobulin Receptor/Secretory Component–Deficient Mice
Cytokine-Activated Endothelial Cells Delay Neutrophil Apoptosis in Vitro and in Vivo: A Role for Granulocyte/Macrophage Colony-Stimulating Factor
Angela Coxon,Tao Tang,Tanya N. Mayadas
View Articletitled, Cytokine-Activated Endothelial Cells Delay Neutrophil Apoptosis in Vitro and in Vivo<span class="subtitle-colon">: </span><span class="subtitle">A Role for Granulocyte/Macrophage Colony-Stimulating Factor</span>
Sulfation of a High Endothelial Venule–Expressed Ligand for L-Selectin: Effects on Tethering and Rolling of Lymphocytes
Kirsten Tangemann,Annette Bistrup,Stefan Hemmerich,Steven D. Rosen
View Articletitled, Sulfation of a High Endothelial Venule–Expressed Ligand for L-Selectin<span class="subtitle-colon">: </span><span class="subtitle">Effects on Tethering and Rolling of Lymphocytes</span>
Receptor Avidity and Costimulation Specify the Intracellular Ca2+ Signaling Pattern in Cd4+Cd8+ Thymocytes
Bruce D. Freedman,Qing-Hua Liu,Selin Somersan,Michael I. Kotlikoff,Jennifer A. Punt
View Articletitled, Receptor Avidity and Costimulation Specify the Intracellular Ca<sup>2+</sup> Signaling Pattern in Cd4<sup>+</sup>Cd8<sup>+</sup> Thymocytes
Tumor Necrosis Factor α Is a Critical Component of Interleukin 13–Mediated Protective T Helper Cell Type 2 Responses during Helminth Infection
David Artis,Neil E. Humphreys,Allison J. Bancroft,Nancy J. Rothwell,Christopher S. Potten,Richard K. Grencis
View Articletitled, Tumor Necrosis Factor α Is a Critical Component of Interleukin 13–Mediated Protective T Helper Cell Type 2 Responses during Helminth Infection
A Defect in Interleukin 12–Induced Activation and Interferon γ Secretion of Peripheral Natural Killer T Cells in Nonobese Diabetic Mice Suggests New Pathogenic Mechanisms for Insulin-Dependent Diabetes Mellitus
Marika Falcone,Brian Yeung,Lee Tucker,Enrique Rodriguez,Nora Sarvetnick
View Articletitled, A Defect in Interleukin 12–Induced Activation and Interferon γ Secretion of Peripheral Natural Killer T Cells in Nonobese Diabetic Mice Suggests New Pathogenic Mechanisms for Insulin-Dependent Diabetes Mellitus
Defective Development of γ/δ T Cells in Interleukin 7 Receptor–Deficient Mice Is Due to Impaired Expression of T Cell Receptor γ Genes
Joonsoo Kang,Mark Coles,David H. Raulet
View Articletitled, Defective Development of γ/δ T Cells in Interleukin 7 Receptor–Deficient Mice Is Due to Impaired Expression of T Cell Receptor γ Genes
The Stimulation of Low-Affinity, Nontolerized Clones by Heteroclitic Antigen Analogues Causes the Breaking of Tolerance Established to an Immunodominant T Cell Epitope
Rongfang Wang,Yiran Wang-Zhu,Claudia Raja Gabaglia,Kazuhiko Kimachi,Howard M. Grey
View Articletitled, The Stimulation of Low-Affinity, Nontolerized Clones by Heteroclitic Antigen Analogues Causes the Breaking of Tolerance Established to an Immunodominant T Cell Epitope
An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation
Chrystelle Asseman,Smita Mauze,Michael W. Leach,Robert L. Coffman,Fiona Powrie
View Articletitled, An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation
Inhibitory Receptors Alter Natural Killer Cell Interactions with Target Cells Yet Allow Simultaneous Killing of Susceptible Targets
Mikael Eriksson,Guenther Leitz,Erik Fällman,Ove Axner,James C. Ryan,Mary C. Nakamura,Charles L. Sentman
View Articletitled, Inhibitory Receptors Alter Natural Killer Cell Interactions with Target Cells Yet Allow Simultaneous Killing of Susceptible Targets
Interleukin 2, but Not Other Common γ Chain–Binding Cytokines, Can Reverse the Defect in Generation of Cd4 Effector T Cells from Naive T Cells of Aged Mice
Laura Haynes,Phyllis-Jean Linton,Sheri M. Eaton,Susan L. Tonkonogy,Susan L. Swain
View Articletitled, Interleukin 2, but Not Other Common γ Chain–Binding Cytokines, Can Reverse the Defect in Generation of Cd4 Effector T Cells from Naive T Cells of Aged Mice
The Inhibitor of Death Receptor Signaling, Flice-Inhibitory Protein Defines a New Class of Tumor Progression Factors
Mounira Djerbi,Valentina Screpanti,Anca Irinel Catrina,Bjarne Bogen,Peter Biberfeld,Alf Grandien
View Articletitled, The Inhibitor of Death Receptor Signaling, Flice-Inhibitory Protein Defines a New Class of Tumor Progression Factors

Brief Definitive Report

Immune Escape of Tumors in Vivo by Expression of Cellular Flice-Inhibitory Protein
Jan Paul Medema,Joan de Jong,Thorbald van Hall,Cornelis J.M. Melief,Rienk Offringa
View Articletitled, Immune Escape of Tumors in Vivo by Expression of Cellular Flice-Inhibitory Protein

Most Read

Role of affinity in plasma cell development in the germinal center light zone
A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation
Leukotriene B4 amplifies eosinophil accumulation in response to nematodes
STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells
Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease

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