The interaction of natural killer (NK) cells with sensitive targets results in the activation of numerous intracellular biochemical cascades. Of utmost importance is the polarization of the cytotoxic granules toward the target cell, which is brought about through reorganization of the actin cytoskeleton and formation of the microtubule organizing center. The image depicts the interaction of NK cells with the NK-sensitive erythroid leukemia target cell line K562 in which the cytolytic granules have either polarized (lower left) or not polarized (upper right) toward the target cell. The granules were stained with acridine orange and visualized using fluorescence microscopy. See related article in this issue by Billadeau et al., pp. 549–559.
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Activated Murine B Lymphocytes and Dendritic Cells Produce a Novel CC Chemokine which Acts Selectively on Activated T Cells
Identification of Putative Cytoskeletal Protein Homologues in the Protozoan Host Hartmannella vermiformis as Substrates for Induced Tyrosine Phosphatase Activity upon Attachment to the Legionnaires' Disease Bacterium, Legionella pneumophila
T Cell Receptor (TCR) Interacting Molecule (TRIM), A Novel Disulfide-linked Dimer Associated with the TCR–CD3–ζ Complex, Recruits Intracellular Signaling Proteins to the Plasma Membrane
Interleukin 12–mediated Prevention of Spontaneous Mammary Adenocarcinomas in Two Lines of Her-2/neu Transgenic Mice
Brief Definitive Report