Issues

Expression of soluble truncated CD44 abrogates lung metastasis formation by TA3/st mammary carcinoma cells after intravenous injection into syngeneic mice (left). In contrast, wild-type tumor cells or tumor cells expressing soluble truncated CD44 bearing the R43A mutation, which abrogates CD44 binding of hyaluronan, form multiple tumor nodules within weeks of injection (right). See related article in this issue by Yu et al., pp. 1985–1996.