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7 July 1997

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Angiogenesis can be induced in vivo by anti-Fas (CD95) mAbs. Matrigel impregnated with anti-Fas mAb was implanted subcutaneously in mice. Endothelial cells are induced to migrate in from the periphery as cords of cells, which form lumena and communicate with preexisting vessels. Shown here are cross-sections through mature vessels within the matrix background at day 4–6. The vascular structures shown in this hematoxylin and eosin–stained section contain red and white blood cells. See related article in this issue by Biancone pp. 147–152.
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