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Volume 179, Issue 2

1 February 1994

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Table of Contents
Editorial Board

ISSN 0022-1007

EISSN 1540-9538

In this Issue

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A triple tribute to the experiment that transformed biology.

R M Steinman,C L Moberg

View Articletitled, A triple tribute to the experiment that transformed biology.

Article

A retrospective look: how we identified the pneumococcal transforming substance as DNA.

M McCarty

View Articletitled, A retrospective look: how we identified the pneumococcal transforming substance as DNA.

Comparison of somatic mutation frequency among immunoglobulin genes.

N Motoyama,T Miwa,Y Suzuki,H Okada,T Azuma

View Articletitled, Comparison of somatic mutation frequency among immunoglobulin genes.

Clearance of NH2-terminal propeptides of types I and III procollagen is a physiological function of the scavenger receptor in liver endothelial cells.

J Melkko,T Hellevik,L Risteli,J Risteli,B Smedsrød

View Articletitled, Clearance of NH2-terminal propeptides of types I and III procollagen is a physiological function of the scavenger receptor in liver endothelial cells.

Selective anergy of V beta 8+ T cells in human immunodeficiency virus-infected individuals.

G Dadaglio,S Garcia,L Montagnier,M L Gougeon

View Articletitled, Selective anergy of V beta 8+ T cells in human immunodeficiency virus-infected individuals.

Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells.

M P Cooke,A W Heath,K M Shokat,Y Zeng,F D Finkelman,P S Linsley,M Howard,C C Goodnow

View Articletitled, Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells.

The mouse mammary tumor virus envelope gene product is required for superantigen presentation to T cells.

T V Golovkina,A Chervonsky,J A Prescott,C A Janeway, Jr,S R Ross

View Articletitled, The mouse mammary tumor virus envelope gene product is required for superantigen presentation to T cells.

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.

S L Reiner,S Zheng,Z E Wang,L Stowring,R M Locksley

View Articletitled, Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.

Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface.

E Matsuura,Y Igarashi,T Yasuda,D A Triplett,T Koike

View Articletitled, Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface.

Characterization of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte clones isolated during acute seroconversion: recognition of autologous virus sequences within a conserved immunodominant epitope.

J T Safrit,C A Andrews,T Zhu,D D Ho,R A Koup

View Articletitled, Characterization of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte clones isolated during acute seroconversion: recognition of autologous virus sequences within a conserved immunodominant epitope.

Lysis of ras oncogene-transformed cells by specific cytotoxic T lymphocytes elicited by primary in vitro immunization with mutated ras peptide.

D J Peace,J W Smith,W Chen,S G You,W L Cosand,J Blake,M A Cheever

View Articletitled, Lysis of ras oncogene-transformed cells by specific cytotoxic T lymphocytes elicited by primary in vitro immunization with mutated ras peptide.

"Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.

T F Gajewski,D W Lancki,R Stack,F W Fitch

View Articletitled, "Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.

High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.

R Bacchetta,M Bigler,J L Touraine,R Parkman,P A Tovo,J Abrams,R de Waal Malefyt,J E de Vries,M G Roncarolo

View Articletitled, High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.

NF-kappa B and I kappa B alpha: an inducible regulatory system in endothelial activation.

M A Read,M Z Whitley,A J Williams,T Collins

View Articletitled, NF-kappa B and I kappa B alpha: an inducible regulatory system in endothelial activation.

Disseminated human immunodeficiency virus 1 (HIV-1) infection in SCID-hu mice after peripheral inoculation with HIV-1.

T R Kollmann,M Pettoello-Mantovani,X Zhuang,A Kim,M Hachamovitch,P Smarnworawong,A Rubinstein,H Goldstein

View Articletitled, Disseminated human immunodeficiency virus 1 (HIV-1) infection in SCID-hu mice after peripheral inoculation with HIV-1.

Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity.

L Chen,P McGowan,S Ashe,J Johnston,Y Li,I Hellström,K E Hellström

View Articletitled, Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity.

Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator.

T N Schumacher,D V Kantesaria,M T Heemels,P G Ashton-Rickardt,J C Shepherd,K Fruh,Y Yang,P A Peterson,S Tonegawa,H L Ploegh

View Articletitled, Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator.

A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides.

E Mellins,P Cameron,M Amaya,S Goodman,D Pious,L Smith,B Arp

View Articletitled, A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides.

Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction.

P Kanakaraj,B Duckworth,L Azzoni,M Kamoun,L C Cantley,B Perussia

View Articletitled, Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction.

Separate metabolic pathways leading to DNA fragmentation and apoptotic chromatin condensation.

D Y Sun,S Jiang,L M Zheng,D M Ojcius,J D Young

View Articletitled, Separate metabolic pathways leading to DNA fragmentation and apoptotic chromatin condensation.

The third component of complement protects against Escherichia coli endotoxin-induced shock and multiple organ failure.

Z M Quezado,W D Hoffman,J A Winkelstein,I Yatsiv,C A Koev,L C Cork,R J Elin,P Q Eichacker,C Natanson

View Articletitled, The third component of complement protects against Escherichia coli endotoxin-induced shock and multiple organ failure.

A nonpolymorphic major histocompatibility complex class Ib molecule binds a large array of diverse self-peptides.

S Joyce,P Tabaczewski,R H Angeletti,S G Nathenson,I Stroynowski

View Articletitled, A nonpolymorphic major histocompatibility complex class Ib molecule binds a large array of diverse self-peptides.

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

F Powrie,R Correa-Oliveira,S Mauze,R L Coffman

View Articletitled, Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

Salmonella stimulate macrophage macropinocytosis and persist within spacious phagosomes.

C M Alpuche-Aranda,E L Racoosin,J A Swanson,S I Miller

View Articletitled, Salmonella stimulate macrophage macropinocytosis and persist within spacious phagosomes.

Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy".

D N Posnett,R Sinha,S Kabak,C Russo

View Articletitled, Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy".

Characterization of the function of intercellular adhesion molecule (ICAM)-3 and comparison with ICAM-1 and ICAM-2 in immune responses.

A R de Fougerolles,X Qin,T A Springer

View Articletitled, Characterization of the function of intercellular adhesion molecule (ICAM)-3 and comparison with ICAM-1 and ICAM-2 in immune responses.

Variability of a bacterial surface protein and disease expression in a possible mouse model of systemic Lyme borreliosis.

D Cadavid,D D Thomas,R Crawley,A G Barbour

View Articletitled, Variability of a bacterial surface protein and disease expression in a possible mouse model of systemic Lyme borreliosis.

Macrophage inflammatory protein 1 alpha, interleukin 3 and diffusible marrow stromal factors maintain human hematopoietic stem cells for at least eight weeks in vitro.

C M Verfaillie,P M Catanzarro,W N Li

View Articletitled, Macrophage inflammatory protein 1 alpha, interleukin 3 and diffusible marrow stromal factors maintain human hematopoietic stem cells for at least eight weeks in vitro.

The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.

J B Weinberg,D L Granger,D S Pisetsky,M F Seldin,M A Misukonis,S N Mason,A M Pippen,P Ruiz,E R Wood,G S Gilkeson

View Articletitled, The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.

The CD8+ T cell repertoire in beta 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I.

R Glas,C Ohlén,P Höglund,K Kärre

View Articletitled, The CD8+ T cell repertoire in beta 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I.

Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2.

C L Ren,T Morio,S M Fu,R S Geha

View Articletitled, Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2.

The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules.

E A Elliott,J R Drake,S Amigorena,J Elsemore,P Webster,I Mellman,R A Flavell

View Articletitled, The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules.

Rapid clearance of malaria circumsporozoite protein (CS) by hepatocytes.

C Cerami,U Frevert,P Sinnis,B Takacs,V Nussenzweig

View Articletitled, Rapid clearance of malaria circumsporozoite protein (CS) by hepatocytes.

Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion.

S Dubucquoi,P Desreumaux,A Janin,O Klein,M Goldman,J Tavernier,A Capron,M Capron

View Articletitled, Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion.

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.

J A Punt,B A Osborne,Y Takahama,S O Sharrow,A Singer

View Articletitled, Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.

The combination of anti-B7 monoclonal antibody and cyclosporin A induces alloantigen-specific anergy during a primary mixed lymphocyte reaction.

S W Van Gool,M de Boer,J L Ceuppens

View Articletitled, The combination of anti-B7 monoclonal antibody and cyclosporin A induces alloantigen-specific anergy during a primary mixed lymphocyte reaction.

Fetal liver and bone marrow JORO 75+ lymphocyte progenitors are precursors of CD4+8- TCR/CD3- early thymocytes.

E Golunski,R Palacios

View Articletitled, Fetal liver and bone marrow JORO 75+ lymphocyte progenitors are precursors of CD4+8- TCR/CD3- early thymocytes.

Evidence for differential intracellular signaling via CD4 and CD8 molecules.

K S Ravichandran,S J Burakoff

View Articletitled, Evidence for differential intracellular signaling via CD4 and CD8 molecules.

Suppression of human alpha-globin gene expression mediated by the recombinant adeno-associated virus 2-based antisense vectors.

S Ponnazhagan,M L Nallari,A Srivastava

View Articletitled, Suppression of human alpha-globin gene expression mediated by the recombinant adeno-associated virus 2-based antisense vectors.

The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor.

F Re,M Muzio,M De Rossi,N Polentarutti,J G Giri,A Mantovani,F Colotta

View Articletitled, The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor.

Expression of functional high affinity immunoglobulin E receptors (Fc epsilon RI) on monocytes of atopic individuals.

D Maurer,E Fiebiger,B Reininger,B Wolff-Winiski,M H Jouvin,O Kilgus,J P Kinet,G Stingl

View Articletitled, Expression of functional high affinity immunoglobulin E receptors (Fc epsilon RI) on monocytes of atopic individuals.

Monocyte chemotactic protein 3 is a most effective basophil- and eosinophil-activating chemokine.

C A Dahinden,T Geiser,T Brunner,V von Tscharner,D Caput,P Ferrara,A Minty,M Baggiolini

View Articletitled, Monocyte chemotactic protein 3 is a most effective basophil- and eosinophil-activating chemokine.

Human interleukin 10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3.

F Brière,C Servet-Delprat,J M Bridon,J M Saint-Remy,J Banchereau

View Articletitled, Human interleukin 10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3.

Distinct structural compartmentalization of the signal transducing functions of major histocompatibility complex class II (Ia) molecules.

P André,J C Cambier,T K Wade,T Raetz,W F Wade

View Articletitled, Distinct structural compartmentalization of the signal transducing functions of major histocompatibility complex class II (Ia) molecules.

Susceptibility to cytotoxic T lymphocyte-induced apoptosis is a function of the proliferative status of the target.

W K Nishioka,R M Welsh

View Articletitled, Susceptibility to cytotoxic T lymphocyte-induced apoptosis is a function of the proliferative status of the target.

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