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Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

In Special Collection:

2018: The Year in Experimental Medicine , Cytokines 2018 , Innate Immune Sensors in Health and Disease , JEM Immunology Collection 2018

Dave Boucher, Mercedes Monteleone, Rebecca C. Coll, Kaiwen W. Chen, Connie M. Ross, Jessica L. Teo, Guillermo A. Gomez, Caroline L. Holley, Damien Bierschenk, Katryn J. Stacey, Alpha S. Yap, Jelena S. Bezbradica, Kate Schroder

J Exp Med (2018) 215 (3): 827–840.

DOI: https://doi.org/10.1084/jem.20172222

Published: 06 February 2018

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Includes: Supplementary data

Journal Articles

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly

Florian I. Schmidt, Alvin Lu, Jeff W. Chen, Jianbin Ruan, Catherine Tang, Hao Wu, Hidde L. Ploegh

J Exp Med (2016) 213 (5): 771–790.

DOI: https://doi.org/10.1084/jem.20151790

Published: 11 April 2016

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Includes: Supplementary data

Journal Articles

Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis

Georg F. Weber, Benjamin G. Chousterman, Ingo Hilgendorf, Clinton S. Robbins, Igor Theurl, Louisa M.S. Gerhardt, Yoshiko Iwamoto, Tam D. Quach, Muhammad Ali, John W. Chen, Thomas L. Rothstein, Matthias Nahrendorf, Ralph Weissleder, Filip K. Swirski

J Exp Med (2014) 211 (6): 1243–1256.

DOI: https://doi.org/10.1084/jem.20131471

Published: 12 May 2014

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Journal Articles

Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo.

S J Khoury, L Gallon, W Chen, K Betres, M E Russell, W W Hancock, C B Carpenter, M H Sayegh, H L Weiner

J Exp Med (1995) 182 (2): 357–366.

DOI: https://doi.org/10.1084/jem.182.2.357

Published: 01 August 1995

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Journal Articles

T cell receptor V beta repertoire in an acute infection of rhesus monkeys with simian immunodeficiency viruses and a chimeric simian-human immunodeficiency virus.

Z W Chen, Z C Kou, C Lekutis, L Shen, D Zhou, M Halloran, J Li, J Sodroski, D Lee-Parritz, N L Letvin

J Exp Med (1995) 182 (1): 21–31.

DOI: https://doi.org/10.1084/jem.182.1.21

Published: 01 July 1995

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Journal Articles

Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues.

W Chen, S Khilko, J Fecondo, D H Margulies, J McCluskey

J Exp Med (1994) 180 (4): 1471–1483.

DOI: https://doi.org/10.1084/jem.180.4.1471

Published: 01 October 1994

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Journal Articles

Lysis of ras oncogene-transformed cells by specific cytotoxic T lymphocytes elicited by primary in vitro immunization with mutated ras peptide.

D J Peace, J W Smith, W Chen, S G You, W L Cosand, J Blake, M A Cheever

J Exp Med (1994) 179 (2): 473–479.

DOI: https://doi.org/10.1084/jem.179.2.473

Published: 01 February 1994

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Journal Articles

Changes at peptide residues buried in the major histocompatibility complex (MHC) class I binding cleft influence T cell recognition: a possible role for indirect conformational alterations in the MHC class I or bound peptide in determining T cell recognition.

W Chen, J McCluskey, S Rodda, F R Carbone

J Exp Med (1993) 177 (3): 869–873.

DOI: https://doi.org/10.1084/jem.177.3.869

Published: 01 March 1993

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Journal Articles

Resolution of Pneumocystis carinii pneumonia in CD4+ lymphocyte-depleted mice given aerosols of heat-treated Escherichia coli.

A G Harmsen, W Chen

J Exp Med (1992) 176 (3): 881–886.

DOI: https://doi.org/10.1084/jem.176.3.881

Published: 01 September 1992

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Journal Articles

Interleukin 1: an important mediator of host resistance against Pneumocystis carinii.

W Chen, E A Havell, L L Moldawer, K W McIntyre, R A Chizzonite, A G Harmsen

J Exp Med (1992) 176 (3): 713–718.

DOI: https://doi.org/10.1084/jem.176.3.713

Published: 01 September 1992

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Journal Articles

Production of tumor necrosis factor/cachectin by human B cell lines and tonsillar B cells.

S S Sung, L K Jung, J A Walters, W Chen, C Y Wang, S M Fu

J Exp Med (1988) 168 (5): 1539–1551.

DOI: https://doi.org/10.1084/jem.168.5.1539

Published: 01 November 1988

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Journal Articles

Double isotype production by a neoplastic B cell line. I. Cellular and biochemical characterization of a variant of BCL1 that expresses and secretes both IgM and IgG1.

Y W Chen, C J Word, S Jones, J W Uhr, P W Tucker, E S Vitetta

J Exp Med (1986) 164 (2): 548–561.

DOI: https://doi.org/10.1084/jem.164.2.548

Published: 01 August 1986

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Journal Articles

Double isotype production by a neoplastic B cell line. II. Allelically excluded production of mu and gamma 1 heavy chains without CH gene rearrangement.

Y W Chen, C Word, V Dev, J W Uhr, E S Vitetta, P W Tucker

J Exp Med (1986) 164 (2): 562–579.

DOI: https://doi.org/10.1084/jem.164.2.562

Published: 01 August 1986

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Journal Articles

Physiology of IgD. I. Compensatory phenomena in B lymphocyte activation in mice treated with anti-IgD antibodies.

E B Jacobson, Y Baine, Y W Chen, T Flotte, M J O'Neil, B Pernis, G W Siskind, G J Thorbecke, P Tonda

J Exp Med (1981) 154 (2): 318–332.

DOI: https://doi.org/10.1084/jem.154.2.318

Published: 01 August 1981

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NARROW

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly

Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis

Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo.

T cell receptor V beta repertoire in an acute infection of rhesus monkeys with simian immunodeficiency viruses and a chimeric simian-human immunodeficiency virus.

Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues.

Lysis of ras oncogene-transformed cells by specific cytotoxic T lymphocytes elicited by primary in vitro immunization with mutated ras peptide.

Changes at peptide residues buried in the major histocompatibility complex (MHC) class I binding cleft influence T cell recognition: a possible role for indirect conformational alterations in the MHC class I or bound peptide in determining T cell recognition.

Resolution of Pneumocystis carinii pneumonia in CD4+ lymphocyte-depleted mice given aerosols of heat-treated Escherichia coli.

Interleukin 1: an important mediator of host resistance against Pneumocystis carinii.

Production of tumor necrosis factor/cachectin by human B cell lines and tonsillar B cells.

Double isotype production by a neoplastic B cell line. I. Cellular and biochemical characterization of a variant of BCL1 that expresses and secretes both IgM and IgG1.

Double isotype production by a neoplastic B cell line. II. Allelically excluded production of mu and gamma 1 heavy chains without CH gene rearrangement.

Physiology of IgD. I. Compensatory phenomena in B lymphocyte activation in mice treated with anti-IgD antibodies.

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