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Mínguez-Martínez et al. (https://doi.org/10.1084/jem.20242085) identify a cooperative RBPJ-STAT5-SMAD4-RXRα-PPARγ transcriptional network that integrates DLL4, GM-CSF, and TGFβ signals to establish alveolar macrophage identity. Their findings position endothelial DLL4 as early licensing signal that enables recruited monocytes to acquire tissue-resident macrophage fate.
Subjects:
Innate immunity and inflammation
© 2026 Verwaerde et al.
2026
Verwaerde et al.
This article is distributed under the terms as described at https://rupress.org/pages/terms102024/.
Subjects:
Innate immunity and inflammation
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