CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells

Henri, Sandrine; Poulin, Lionel Franz; Tamoutounour, Samira; Ardouin, Laurence; Guilliams, Martin; de Bovis, Béatrice; Devilard, Elisabeth; Viret, Christophe; Azukizawa, Hiroaki; Kissenpfennig, Adrien; Malissen, Bernard

doi:10.1084/jem.2009196412910c

Vol. 207, No. 1, January 18, 2010. Pages 189–206.

The authors regret that data was presented incorrectly in Table I of their article. The errors have been corrected in the html and pdf versions of the article. The correted table is presented below:

Table I.

Phenotype and frequency of the five skin DC subsets prior to and following their migration to CLNs

Skin subset	Phenotypes	Frequency
		%
Epidermis
Epidermal LCs	CD207⁺⁺, CD11b^int, CD103⁻, EpCAM⁺⁺, CD24⁺, Sirpα⁺	100 ± 1
Dermis
LCs in transit	CD207⁺⁺, CD11b^int, CD103⁻, EpCAM⁺⁺, CD24⁺, Sirpα⁺	6.4 ± 1
CD207⁺ CD103⁻ DDCs	CD207⁺, CD11b^low, CD103⁻, EpCAM^−/low, CD24⁺, Sirpα⁻	2.8 ± 0.5
CD207⁺ CD103⁺ DDCs	CD207⁺, CD11b^low, CD103⁺, EpCAM^−/low, CD24⁺, Sirpα⁻	2.6 ± 0.6
CD207⁻ CD11b⁻ DDCs	CD207⁻, CD11b^−/low, CD103⁻, EpCAM⁻, CD24⁻, Sirpα^low	16.3 ± 1.3
CD207⁻ CD11b⁺ DDCs	CD207⁻, CD11b^high, CD103⁻, EpCAM⁻, CD24⁻, Sirpα⁺	65.8 ± 5
CLNs
mLCs	CD207⁺, CD11b^−/low ↓, CD103⁻, EpCAM⁺, CD24⁺, Sirpα⁺	9.5 ± 2.9
CD207⁺ CD103⁻ mDDCs	CD207⁺, CD11b^−/low, CD103⁻, EpCAM⁺ ↑, CD24⁺, Sirpα⁺ ↑	7.0 ± 4.2
CD207⁺ CD103⁺ mDDCs	CD207⁺, CD11b^−/low, CD103⁺, EpCAM⁺ ↑, CD24⁺, Sirpα^low	13.5 ± 4.5
CD207⁻ CD11b⁻ mDDCs	CD207⁻, CD11b⁻, CD103^bim ↑, EpCAM^bim ↑, CD24^bim ↑, Sirpα⁺ ↑	20.8 ± 2.5
CD207⁻ CD11b⁺ mDDCs	CD207⁻, CD11b⁺, CD103^bim ↑, EpCAM^int ↑, CD24^int ↑, Sirpα⁺	35.2 ± 2.6

Skin subset	Phenotypes	Frequency
		%
Epidermis
Epidermal LCs	CD207⁺⁺, CD11b^int, CD103⁻, EpCAM⁺⁺, CD24⁺, Sirpα⁺	100 ± 1
Dermis
LCs in transit	CD207⁺⁺, CD11b^int, CD103⁻, EpCAM⁺⁺, CD24⁺, Sirpα⁺	6.4 ± 1
CD207⁺ CD103⁻ DDCs	CD207⁺, CD11b^low, CD103⁻, EpCAM^−/low, CD24⁺, Sirpα⁻	2.8 ± 0.5
CD207⁺ CD103⁺ DDCs	CD207⁺, CD11b^low, CD103⁺, EpCAM^−/low, CD24⁺, Sirpα⁻	2.6 ± 0.6
CD207⁻ CD11b⁻ DDCs	CD207⁻, CD11b^−/low, CD103⁻, EpCAM⁻, CD24⁻, Sirpα^low	16.3 ± 1.3
CD207⁻ CD11b⁺ DDCs	CD207⁻, CD11b^high, CD103⁻, EpCAM⁻, CD24⁻, Sirpα⁺	65.8 ± 5
CLNs
mLCs	CD207⁺, CD11b^−/low ↓, CD103⁻, EpCAM⁺, CD24⁺, Sirpα⁺	9.5 ± 2.9
CD207⁺ CD103⁻ mDDCs	CD207⁺, CD11b^−/low, CD103⁻, EpCAM⁺ ↑, CD24⁺, Sirpα⁺ ↑	7.0 ± 4.2
CD207⁺ CD103⁺ mDDCs	CD207⁺, CD11b^−/low, CD103⁺, EpCAM⁺ ↑, CD24⁺, Sirpα^low	13.5 ± 4.5
CD207⁻ CD11b⁻ mDDCs	CD207⁻, CD11b⁻, CD103^bim ↑, EpCAM^bim ↑, CD24^bim ↑, Sirpα⁺ ↑	20.8 ± 2.5
CD207⁻ CD11b⁺ mDDCs	CD207⁻, CD11b⁺, CD103^bim ↑, EpCAM^int ↑, CD24^int ↑, Sirpα⁺	35.2 ± 2.6

The percentage ± SEM of each subset among MHCII⁺ (epidermis and dermis) or MHCII^high CD11c^{inter-to-high} (CLN) cells were calculated from at least six independent experiments. Upward and downward pointing arrows indicate markers that were up-regulated or down-regulated, respectively, upon migration to CLNs. Bim, bimodal.

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CD207⁺ CD103⁺ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells

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CD207⁺ CD103⁺ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells