Table I. Phenotype and frequency of the... | Rockefeller University Press

Table I.

Phenotype and frequency of the five skin DC subsets prior to and following their migration to CLNs

Skin subset	Phenotypes	Frequency
		%
Epidermis
Epidermal LCs	CD207⁺⁺, CD11b^int, CD103⁻, EpCAM⁺⁺, CD24⁺, Sirpα⁺	100 ± 1
Dermis
LCs in transit	CD207⁺⁺, CD11b^int, CD103⁻, EpCAM⁺⁺, CD24⁺, Sirpα⁺	6.4 ± 1
CD207⁺ CD103⁻ DDCs	CD207⁺, CD11b^low, CD103⁻, EpCAM^−/low, CD24⁺, Sirpα⁻	2.8 ± 0.5
CD207⁺ CD103⁺ DDCs	CD207⁺, CD11b^low, CD103⁺, EpCAM^−/low, CD24⁺, Sirpα⁻	2.6 ± 0.6
CD207⁻ CD11b⁻ DDCs	CD207⁻, CD11b^−/low, CD103⁻, EpCAM⁻, CD24⁻, Sirpα^low	16.3 ± 1.3
CD207⁻ CD11b⁺ DDCs	CD207⁻, CD11b^high, CD103⁻, EpCAM⁻, CD24⁻, Sirpα⁺	65.8 ± 5
CLNs
mLCs	CD207⁺, CD11b^−/low ↓, CD103⁻, EpCAM⁺, CD24⁺, Sirpα⁺	9.5 ± 2.9
CD207⁺ CD103⁻ mDDCs	CD207⁺, CD11b^−/low, CD103⁻, EpCAM⁺ ↑, CD24⁺, Sirpα⁺ ↑	7.0 ± 4.2
CD207⁺ CD103⁺ mDDCs	CD207⁺, CD11b^−/low, CD103⁺, EpCAM⁺ ↑, CD24⁺, Sirpα^low	13.5 ± 4.5
CD207⁻ CD11b⁻ mDDCs	CD207⁻, CD11b⁻, CD103^bim ↑, EpCAM^bim ↑, CD24^bim ↑, Sirpα⁺ ↑	20.8 ± 2.5
CD207⁻ CD11b⁺ mDDCs	CD207⁻, CD11b⁺, CD103^bim ↑, EpCAM^int ↑, CD24^int ↑, Sirpα⁺	35.2 ± 2.6

Skin subset	Phenotypes	Frequency
		%
Epidermis
Epidermal LCs	CD207⁺⁺, CD11b^int, CD103⁻, EpCAM⁺⁺, CD24⁺, Sirpα⁺	100 ± 1
Dermis
LCs in transit	CD207⁺⁺, CD11b^int, CD103⁻, EpCAM⁺⁺, CD24⁺, Sirpα⁺	6.4 ± 1
CD207⁺ CD103⁻ DDCs	CD207⁺, CD11b^low, CD103⁻, EpCAM^−/low, CD24⁺, Sirpα⁻	2.8 ± 0.5
CD207⁺ CD103⁺ DDCs	CD207⁺, CD11b^low, CD103⁺, EpCAM^−/low, CD24⁺, Sirpα⁻	2.6 ± 0.6
CD207⁻ CD11b⁻ DDCs	CD207⁻, CD11b^−/low, CD103⁻, EpCAM⁻, CD24⁻, Sirpα^low	16.3 ± 1.3
CD207⁻ CD11b⁺ DDCs	CD207⁻, CD11b^high, CD103⁻, EpCAM⁻, CD24⁻, Sirpα⁺	65.8 ± 5
CLNs
mLCs	CD207⁺, CD11b^−/low ↓, CD103⁻, EpCAM⁺, CD24⁺, Sirpα⁺	9.5 ± 2.9
CD207⁺ CD103⁻ mDDCs	CD207⁺, CD11b^−/low, CD103⁻, EpCAM⁺ ↑, CD24⁺, Sirpα⁺ ↑	7.0 ± 4.2
CD207⁺ CD103⁺ mDDCs	CD207⁺, CD11b^−/low, CD103⁺, EpCAM⁺ ↑, CD24⁺, Sirpα^low	13.5 ± 4.5
CD207⁻ CD11b⁻ mDDCs	CD207⁻, CD11b⁻, CD103^bim ↑, EpCAM^bim ↑, CD24^bim ↑, Sirpα⁺ ↑	20.8 ± 2.5
CD207⁻ CD11b⁺ mDDCs	CD207⁻, CD11b⁺, CD103^bim ↑, EpCAM^int ↑, CD24^int ↑, Sirpα⁺	35.2 ± 2.6

The percentage ± SEM of each subset among MHCII⁺ (epidermis and dermis) or MHCII^high CD11c^{inter-to-high} (CLN) cells were calculated from at least six independent experiments. Upward and downward pointing arrows indicate markers that were up-regulated or down-regulated, respectively, upon migration to CLNs. Bim, bimodal.

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