Article
E- and N-cadherin drive hepatic polarity and lumen elongation via opposing effects on RhoA activity
Hayase et al. show that E-cadherin promotes bile canaliculus elongation via RhoA activation and oriented cell division, while N-cadherin maintains hepatic polarity by attenuating RhoA, defining distinct roles of dual cadherin expression in hepatocytes.
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Design principles of human membrane protein topology
Wu and Hegde annotate and analyze the topology of 4,863 human endoplasmic reticulum–inserted membrane proteins and their 20,546 transmembrane domains. Their analysis shows that transmembrane domains inserted by different pathways can tolerate different biophysical properties.
