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Insights into retinal disease and non-tubulin glutamylation from a RPGR–TTLL5 complex structure
Park et al. present the crystal structure of an RPGR–TTLL5 co-complex, which reveals TTLL recognition paradigms for non-tubulin substrates and sheds light on disease mechanism for retinal dystrophies caused by TTLL5 and RPGR mutations.
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PI(3)P regulates mitochondrial dynamics through FGD-dependent actin organization
Zhao et al. reveal that PI(3)P-dependent recruitment of FGD at endosome–mitochondrion contacts activates CDC42 to regulate mitochondrial networks through the actin organization and DRP-1 in Caenorhabditis elegans.
