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Cover Image
Cover Image
On the cover
An anaphase cell carrying a fluorescent mark (green) at a single chromosomal locus correctly segregates its sister chromatids (blue). Thompson and Compton find that the tumor suppressor p53 prevents cells with mis-segregated chromosomes from proliferating further.
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In This Issue
In Focus
People & Ideas
Wolf Reik: Inheritance beyond DNA
Reik takes on the dual nature of epigenetic regulation and finds that it can satisfy his dual tastes for basic research and medicine.
Review
Report
Drosophila Ana2 is a conserved centriole duplication factor
Drosophila protein Ana2 supports de novo formation of centrioles and may be a functional homologue of the C. elegans centriole duplication protein SAS-5.
Dual action of epidermal growth factor: extracellular signal-stimulated nuclear–cytoplasmic export and coordinated translation of selected messenger RNA
EGF triggers dephosphorylation of the mRNA-binding protein Grb7 in the nucleus, leading to its export, and it also stimulates FAK, which rephosphorylates Grb7 in the cytoplasm to release its mRNA cargo for translation.
Article
SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster
Sisters on the loose (SOLO) protein functions as a meiotic cohesin component critical for correct chromosome segregation in Drosophila.
Mutual regulation of cyclin-dependent kinase and the mitotic exit network
Although MEN activity in daughter cells is regulated by the Bfa–Bub1 GAP complex, Cdk1 takes over the job at the mother spindle pole body.
Proliferation of aneuploid human cells is limited by a p53-dependent mechanism
After chromosome missegregation, the growth of nondiploid cells is inhibited thanks to a p53-dependent mechanism.
Fate-determining mechanisms in epithelial–myofibroblast transition: major inhibitory role for Smad3
Smad3 inhibits activation of the smooth muscle actin promoter and functions as a timer for myogenic programming in the epithelium.
Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis
Time-resolved measurements of exocytosis identify a domain of the SNARE complex required to keep vesicles readily releasable.
Localized topological changes of the plasma membrane upon exocytosis visualized by polarized TIRFM
Imaging of individual secretory granules reveals how exocytosis curves the membrane.
Autonomous right-screw rotation of growth cone filopodia drives neurite turning
The clockwise turning of neurites is caused by the rotations of filopodia as they extend and sweep across the substratum.
