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Tumor suppressor stops cells from gaining or losing chromosomes.

People & Ideas

Reik takes on the dual nature of epigenetic regulation and finds that it can satisfy his dual tastes for basic research and medicine.



Drosophila protein Ana2 supports de novo formation of centrioles and may be a functional homologue of the C. elegans centriole duplication protein SAS-5.

EGF triggers dephosphorylation of the mRNA-binding protein Grb7 in the nucleus, leading to its export, and it also stimulates FAK, which rephosphorylates Grb7 in the cytoplasm to release its mRNA cargo for translation.


Sisters on the loose (SOLO) protein functions as a meiotic cohesin component critical for correct chromosome segregation in Drosophila.

Although MEN activity in daughter cells is regulated by the Bfa–Bub1 GAP complex, Cdk1 takes over the job at the mother spindle pole body.

After chromosome missegregation, the growth of nondiploid cells is inhibited thanks to a p53-dependent mechanism.

Smad3 inhibits activation of the smooth muscle actin promoter and functions as a timer for myogenic programming in the epithelium.

Time-resolved measurements of exocytosis identify a domain of the SNARE complex required to keep vesicles readily releasable.

Imaging of individual secretory granules reveals how exocytosis curves the membrane.

The clockwise turning of neurites is caused by the rotations of filopodia as they extend and sweep across the substratum.


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