On the cover
An anaphase cell carrying a fluorescent mark (green) at a single chromosomal locus correctly segregates its sister chromatids (blue). Thompson and Compton find that the tumor suppressor p53 prevents cells with mis-segregated chromosomes from proliferating further.
See page 369.
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People & Ideas
Dual action of epidermal growth factor: extracellular signal-stimulated nuclear–cytoplasmic export and coordinated translation of selected messenger RNA
EGF triggers dephosphorylation of the mRNA-binding protein Grb7 in the nucleus, leading to its export, and it also stimulates FAK, which rephosphorylates Grb7 in the cytoplasm to release its mRNA cargo for translation.
SOLO: a meiotic protein required for centromere cohesion, coorientation, and SMC1 localization in Drosophila melanogaster
Sisters on the loose (SOLO) protein functions as a meiotic cohesin component critical for correct chromosome segregation in Drosophila.
Although MEN activity in daughter cells is regulated by the Bfa–Bub1 GAP complex, Cdk1 takes over the job at the mother spindle pole body.
After chromosome missegregation, the growth of nondiploid cells is inhibited thanks to a p53-dependent mechanism.
Smad3 inhibits activation of the smooth muscle actin promoter and functions as a timer for myogenic programming in the epithelium.
Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis
Time-resolved measurements of exocytosis identify a domain of the SNARE complex required to keep vesicles readily releasable.
The clockwise turning of neurites is caused by the rotations of filopodia as they extend and sweep across the substratum.