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    Fernández-Busnadiego et al. present a three-dimensional view of the presynaptic cytomatrix using cryo-electron tomography. Synaptic vesicles (yellow) are linked to each other by short connector filaments (red) and docked at the plasma membrane (purple) by protein tethers (dark blue).
    See page 145.

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ISSN 0021-9525
EISSN 1540-8140
In this Issue

In This Issue

In Focus

Recreating integrin activation in vitro resolves several long-running controversies.

People & Ideas

Di Fiore specializes in fishing out connections between the endocytic machinery and cancer.



An 18-residue motif in the cytoplasmic tail of polycystic kidney disease gene product, fibrocystin, targets it to ciliary membranes through interactions with Rab8.

In addition to cross-linking F-actin, Drosophila Kelch is a component of a cullin-RING ubiquitin ligase complex required for morphogenesis of ring canals during oogenesis.


Cdc6, which alters chromatin ultrastructure to allow DNA replication in muscle stem cells transitioning out of quiescence, is identified as a target of the MyoD transcription factor.

The lamin-B nuclear envelope stabilizes spindle microtubules by keeping the competitive motility of opposing-force kinesins in check.

A combination of yeast genetics, synthetic genetic array analysis, and high-throughput screening reveals that sumoylation of Mcm21p promotes disassembly of the mitotic spindle.

An overabundance of UbcH10 disrupts mitotic checkpoint signaling as a result of a degradation of cyclin B, increasing spontaneous and carcinogen-induced tumor formation in transgenic mice.

COG subunits localize to the phagophore assembly site where they interact with autophagy proteins and are required for double-membrane Cvt vesicle and autophagosome formation.

If neuropilin-2 and the growth factor VEGF-C don’t come together, lymphatic vessels don’t branch apart.

CHC22 is needed for retrograde trafficking from endosomes to the trans-Golgi, unlike its clathrin sibling CHC17, and in a manner distinct from retromer.

The filamentous structures that tether exocytic vesicles to the plasma membrane in the active zone are rearranged in response to synaptic stimulation.

In vitro analysis confirms talin binding is sufficient for activation and extension of membrane-embedded integrin.

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