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SIRT1 takes down tumors

Mitch Leslie
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Autophagosomes meet before they eat

Mitch Leslie
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When cancer cells can't let go

Mitch Leslie
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In Focus

A plasmid goes motoring

Mitch Leslie

Study suggests that parasitic DNA hitchhikes to its nuclear address on motor protein.

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People & Ideas

Peter Friedl: Painting a picture of cancer immunology

Caitlin Sedwick

Friedl uses confocal and intravital microscopy to investigate the movement of T cells and cancer cells.

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Editorial

New science — new ways to communicate it

Emma Hill,Aimee deCathelineau,Tom Misteli
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Review

The circuitry of cargo flux in the ESCRT pathway

James H. Hurley,Xuefeng Ren
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Puma strikes Bax

Anthony Letai
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The decision to enter mitosis: feedback and redundancy in the mitotic entry network

Arne Lindqvist,Verónica Rodríguez-Bravo,René H. Medema
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Report

A c-Myc–SIRT1 feedback loop regulates cell growth and transformation

Jian Yuan,Katherine Minter-Dykhouse,Zhenkun Lou
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ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting

S. Brookhart Shields,Andrea J. Oestreich,Stanley Winistorfer,Doris Nguyen,Johanna A. Payne,David J. Katzmann,Robert Piper
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Inactivation of Chibby affects function of motile airway cilia

Vera A. Voronina,Ken-Ichi Takemaru,Piper Treuting,Damon Love,Barbara R. Grubb,Adeline M. Hajjar,Allison Adams,Feng-Qian Li,Randall T. Moon
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Article

Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis

Maria Paola Paronetto,Valeria Messina,Enrica Bianchi,Marco Barchi,Gillian Vogel,Costanzo Moretti,Fioretta Palombi,Mario Stefanini,Raffaele Geremia,Stéphane Richard,Claudio Sette
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The selfish yeast plasmid uses the nuclear motor Kip1p but not Cin8p for its localization and equal segregation

Hong Cui,Santanu K. Ghosh,Makkuni Jayaram
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A conserved CCCH-type zinc finger protein regulates mRNA nuclear adenylation and export

Jessica A. Hurt,Robert A. Obar,Bo Zhai,Natalie G. Farny,Steven P. Gygi,Pamela A. Silver
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Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members

Tristan Gallenne,Fabien Gautier,Lisa Oliver,Eric Hervouet,Belinda Noël,John A. Hickman,Olivier Geneste,Pierre-François Cartron,François M. Vallette,Stephen Manon,Philippe Juin
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Caspase-2 activation in the absence of PIDDosome formation

Claudia Manzl,Gerhard Krumschnabel,Florian Bock,Benedicte Sohm,Verena Labi,Florian Baumgartner,Emmanuelle Logette,Jürg Tschopp,Andreas Villunger
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Early endosomes and endosomal coatomer are required for autophagy

Minoo Razi,Edmond Y.W. Chan,Sharon A. Tooze
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Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis

Pirta Hotulainen,Olaya Llano,Sergei Smirnov,Kimmo Tanhuanpää,Jan Faix,Claudio Rivera,Pekka Lappalainen
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Dynein light chain regulates axonal trafficking and synaptic levels of Bassoon

Anna Fejtova,Daria Davydova,Ferdinand Bischof,Vesna Lazarevic,Wilko D. Altrock,Stefano Romorini,Cornelia Schöne,Werner Zuschratter,Michael R. Kreutz,Craig C. Garner,Noam E. Ziv,Eckart D. Gundelfinger
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FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion

Keefe T. Chan,Christa L. Cortesio,Anna Huttenlocher
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