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JCB65: Cell Adhesion and Migration

In the fourth collection celebrating our 65th anniversary, we retrace fundamental discoveries that shaped our understanding of cell–cell and cell–matrix interactions, including basic insights into the components of cell–cell junctions and the ways in which cells adhere to substrates, studies establishing how adhesion receptors signal and fulfill essential roles in regulating gene expression, proliferation, polarity, migration, development, and differentiation. Find work that dissects how contractility drives adhesion formation and how adhesion-mediated responses contribute to development and disease, including cancer. If we missed your favorite JCB study, tweet to @JCellBiol using the hashtag #JCB65, or email us at jcellbiol@rockefeller.edu. Find more 65th anniversary collections or browse our From the Archive series.

Image from Brightman & Reese, 1969.

Report

The myoepithelium actively restrains dissemination

Orit Katarina Sirka; Eliah R. Shamir; Andrew J. Ewald

DOI: 10.1083/jcb.201802144

Article

Adhesion to fibronectin regulates Hippo signaling

Nam-Gyun Kim; Barry M. Gumbiner

DOI: 10.1083/jcb.201501025

Article

ZO-1 controls endothelial cell–cell tension

Olga Tornavaca; Minghao Chia; Neil Dufton; Lourdes Osuna Almagro; Daniel E. Conway; Anna M. Randi; Martin A. Schwartz; Karl Matter; Maria S. Balda

DOI: 10.1083/jcb.201404140

Article

Physical limits of cell migration

Katarina Wolf; Mariska te Lindert; Marina Krause; Stephanie Alexander; Joost te Riet; Amanda L. Willis; Robert M. Hoffman; Carl G. Figdor; Stephen J. Weiss; Peter Friedl

DOI: 10.1083/jcb.201210152

Articles

Vinculin controls focal adhesion formation by direct interactions with talin and actin

Jonathan D. Humphries; Pengbo Wang; Charles Streuli; Benny Geiger; Martin J. Humphries; Christoph Ballestrem

DOI: 10.1083/jcb.200703036

Articles

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial–mesenchymal transition

Hanna Y. Irie; Rachel V. Pearline; Dorre Grueneberg; Maximilian Hsia; Preethi Ravichandran; Nayantara Kothari; Sridaran Natesan; Joan S. Brugge

DOI: 10.1083/jcb.200505087

Articles

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

Holger Gerhardt; Matthew Golding; Marcus Fruttiger; Christiana Ruhrberg; Andrea Lundkvist; Alexandra Abramsson; Michael Jeltsch; Christopher Mitchell; Kari Alitalo; David Shima; Christer Betsholtz

DOI: 10.1083/jcb.200302047

Articles

Compensation mechanism in tumor cell migration : mesenchymal–amoeboid transition after blocking of pericellular proteolysis

Katarina Wolf; Irina Mazo; Harry Leung; Katharina Engelke; Ulrich H. von Andrian; Elena I. Deryugina; Alex Y. Strongin; Eva-B. Bröcker; Peter Friedl

DOI: 10.1083/jcb.200209006

Article

Focal Contacts as Mechanosensors: Externally Applied Local Mechanical Force Induces Growth of Focal Contacts by an Mdia1-Dependent and Rock-Independent Mechanism

Daniel Riveline; Eli Zamir; Nathalie Q. Balaban; Ulrich S. Schwarz; Toshimasa Ishizaki; Shuh Narumiya; Zvi Kam; Benjamin Geiger; Alexander D. Bershadsky

DOI: 10.1083/jcb.153.6.1175

Article

Membrane-Type 1 Matrix Metalloproteinase Cleaves Cd44 and Promotes Cell Migration

Masahiro Kajita; Yoshifumi Itoh; Tadashige Chiba; Hidetoshi Mori; Akiko Okada; Hiroaki Kinoh; Motoharu Seiki

DOI: 10.1083/jcb.153.5.893

Article

Multiple Forces Contribute to Cell Sheet Morphogenesis for Dorsal Closure in Drosophila

Daniel P. Kiehart; Catherine G. Galbraith; Kevin A. Edwards; Wayne L. Rickoll; Ruth A. Montague

DOI: 10.1083/jcb.149.2.471

Article

Exogenous Expression of N-Cadherin in Breast Cancer Cells Induces Cell Migration, Invasion, and Metastasis

Rachel B. Hazan; Greg R. Phillips; Rui Fang Qiao; Larry Norton; Stuart A. Aaronson

DOI: 10.1083/jcb.148.4.779

Article

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

Catherine D. Nobes; Alan Hall

DOI: 10.1083/jcb.144.6.1235

Articles

Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

Inés Martìn-Padura; Susan Lostaglio; Markus Schneemann; Lisa Williams; Maria Romano; Paolo Fruscella; Carla Panzeri; Antonella Stoppacciaro; Luigi Ruco; Antonello Villa; David Simmons; Elisabetta Dejana

DOI: 10.1083/jcb.142.1.117

Articles

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

Mikio Furuse; Kohji Fujita; Takashi Hiiragi; Kazushi Fujimoto; Shoichiro Tsukita

DOI: 10.1083/jcb.141.7.1539

Articles

Rho-mediated Contractility Exposes a Cryptic Site in Fibronectin and Induces Fibronectin Matrix Assembly

Cuiling Zhong; Magdalena Chrzanowska-Wodnicka; James Brown; Amy Shaub; Alexey M. Belkin; Keith Burridge

DOI: 10.1083/jcb.141.2.539

Article

The Ig Superfamily Cell Adhesion Molecule, apCAM, Mediates Growth Cone Steering by Substrate–Cytoskeletal Coupling

Daniel M. Suter; Laura D. Errante; Victoria Belotserkovsky; Paul Forscher