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Neurodegenerative Diseases: Emerging Mechanisms and Therapeutic Opportunities

A selection examining molecular, cellular, clinical, and translational aspects of neurodegeneration. The collection features studies of genetic variants and plasma biomarkers associated with Alzheimer’s disease, as well as analyses of the pathophysiology of neurodegeneration and preclinical validation of novel therapeutics.  The collection also includes several articles investigating how changes in neuronal cell biology, such as mitochondrial stress and alterations in cell signaling and trafficking pathways, impact synaptic function and neuronal survival.

This special collection coincides with the JCBJEM symposium on Neurodegeneration “Neurodegenerative Diseases: Emerging Mechanisms and Therapeutic Opportunities” . We welcome your feedback on social media @JCellBiol and @JExpMed.

For more content of interest to neuroscientists, explore the recent JCB Cellular Neurobiology collection and JEM’s collection on Neurodegenerative Diseases: Biology & Therapeutics.

Special Collection Image
Vineet Vinay Kulkarni; Anip Anand; Jessica Brandt Herr; Christina Miranda; Maria Chalokh Vogel; Sandra Maday
DOI: 10.1083/jcb.202002084
Joohyung Kim; Sungdae Kim; Minyeop Nahm; Tsai-Ning Li; Hsin-Chieh Lin; Yeongjin David Kim; Jihye Lee; Chi-Kuang Yao; Seungbok Lee
DOI: 10.1083/jcb.202007112
Yusuke Fukuda; Maria F. Pazyra-Murphy; Elizabeth S. Silagi; Ozge E. Tasdemir-Yilmaz; Yihang Li; Lillian Rose; Zoe C. Yeoh; Nicholas E. Vangos; Ezekiel A. Geffken; Hyuk-Soo Seo; Guillaume Adelmant; Gregory H. Bird; Loren D. Walensky; Jarrod A. Marto; Sirano Dhe-Paganon; Rosalind A. Segal
DOI: 10.1083/jcb.202005051
Myeong Hoon Han; Min Jee Kwon; Byung Su Ko; Do Young Hyeon; Davin Lee; Hyung-Jun Kim; Daehee Hwang; Sung Bae Lee
DOI: 10.1083/jcb.202004107
Rachel J. Hunt; Lucy Granat; Gregory S. McElroy; Ramya Ranganathan; Navdeep S. Chandel; Joseph M. Bateman
DOI: 10.1083/jcb.201904148
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