Meiotic spindles isolated from surf clam oocytes to morphological purity are biochemically complex, consisting of many polypeptides. These proteins fall into two classes: (a) polypeptides that are apparently cytoplasmic proteins and are not specifically associated with the spindle; and (b) polypeptides that are specifically associated with the spindle. A subset of the spindle-associated proteins, including a 250,000 mol wt component, remain with spindle tubulin through cycles of cold depolymerization and warm polymerization, showing that they are microtubule-associated proteins.
Article| February 01 1980
Identification of microtubule-associated proteins in the meiotic spindle of surf clam oocytes.
D B Murphy
Online ISSN: 1540-8140
Print ISSN: 0021-9525
J Cell Biol (1980) 84 (2): 235–245.
D B Murphy; Identification of microtubule-associated proteins in the meiotic spindle of surf clam oocytes.. J Cell Biol 1 February 1980; 84 (2): 235–245. doi: https://doi.org/10.1083/jcb.84.2.235
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