Cultures of mitotic Chinese hamster cells, prepared by mechanical selection, were pulse-labeled with methionine-methyl-14C or with uridine-3H at different stages in the life cycle. The rate of 14C incorporation into 18S RNA was measured, as was the rate of uridine-3H incorporation into total RNA for both monolayer and suspension cultures. The rate of incorporation increased continuously throughout interphase in a fashion inconsistent with a gene-dosage effect upon RNA synthesis.

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