cDNA encoding the 20-kD subunit of coatomer, zeta-COP, predicts a protein of 177-amino acid residues, similar in sequence to AP17 and AP19, subunits of the clathrin adaptor complexes. Polyclonal antibody directed to zeta-COP blocks the binding of coatomer to Golgi membranes and prevents the assembly of COP-coated vesicles on Golgi cisternae. Unlike other coatomer subunits (beta-, beta'-, gamma-, and epsilon-COP), zeta-COP exists in both coatomer bound and free pools.
zeta-COP, a subunit of coatomer, is required for COP-coated vesicle assembly.
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O Kuge, S Hara-Kuge, L Orci, M Ravazzola, M Amherdt, G Tanigawa, F T Wieland, J E Rothman; zeta-COP, a subunit of coatomer, is required for COP-coated vesicle assembly.. J Cell Biol 15 December 1993; 123 (6): 1727–1734. doi: https://doi.org/10.1083/jcb.123.6.1727
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