THE STRUCTURE OF EOSINOPHIL LEUKOCYTE GRANULES IN RODENTS AND IN MAN

Miller , Fritz; de Harven , Etienne; Palade , George E.

doi:10.1083/jcb.31.2.349

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Article| November 01 1966

THE STRUCTURE OF EOSINOPHIL LEUKOCYTE GRANULES IN RODENTS AND IN MAN

Fritz Miller,

Fritz Miller

From the Pathologisches Institut der Universität München, Germany, the Sloan-Kettering Institute for Cancer Research, New York, and The Rockefeller University, New York

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Etienne de Harven,

Etienne de Harven

From the Pathologisches Institut der Universität München, Germany, the Sloan-Kettering Institute for Cancer Research, New York, and The Rockefeller University, New York

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George E. Palade

From the Pathologisches Institut der Universität München, Germany, the Sloan-Kettering Institute for Cancer Research, New York, and The Rockefeller University, New York

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Author and Article Information

Fritz Miller

From the Pathologisches Institut der Universität München, Germany, the Sloan-Kettering Institute for Cancer Research, New York, and The Rockefeller University, New York

Etienne de Harven

From the Pathologisches Institut der Universität München, Germany, the Sloan-Kettering Institute for Cancer Research, New York, and The Rockefeller University, New York

George E. Palade

From the Pathologisches Institut der Universität München, Germany, the Sloan-Kettering Institute for Cancer Research, New York, and The Rockefeller University, New York

Received: December 14 1965

Online ISSN: 1540-8140

Print ISSN: 0021-9525

1966

J Cell Biol (1966) 31 (2): 349–362.

https://doi.org/10.1083/jcb.31.2.349

The structure of the specific granules of eosinophil leukocytes has been studied by electron microscopy in sections of tissues, buffy coats, and sediments of peritoneal washings of rats, mice, guinea pigs, and men. The core of eosinophil granules is a crystal which has a cubic lattice with a repeat of ∼30 A in rodents and ∼40 A in man. The chemical composition of the core is discussed in connection with recent cell fractionation studies, and the hypothesis that the core is a crystal of peroxidase is considered.

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